PDB: 46200 resultsInfo pagesStatus searchChemie searchBIRD

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5OO0	Cdk2(WT) covalent adduct with D28 at C177 Descriptor: Cyclin-dependent kinase 2, methyl 4-propanoyl-2,3-dihydroquinoxaline-1-carboxylate Authors: Craven, G, Morgan, R.M.L, Mann, D.J. Deposit date: 2017-08-04 Release date: 2018-03-14 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.6 Å) Cite: High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery. Angew. Chem. Int. Ed. Engl., 57, 2018
4GWO	Crystal structure of ligand binding domain of LysR family member,CysB in complex with sulfate from Salmonella typhimurium LT2 Descriptor: GLYCEROL, HTH-type transcriptional regulator CysB, SULFATE ION Authors: Mittal, M, Singh, A.K, Kumaran, S. Deposit date: 2012-09-03 Release date: 2013-09-04 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.394 Å) Cite: Crystal structure of ligand binding domain of LysR family member,CysB in complex with sulfate from Salmonella typhimurium LT2 To be Published
3BWG	The crystal structure of possible transcriptional regulator YydK from Bacillus subtilis subsp. subtilis str. 168 Descriptor: 1,2-ETHANEDIOL, Uncharacterized HTH-type transcriptional regulator yydK Authors: Tan, K, Zhou, M, Abdullah, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) Deposit date: 2008-01-09 Release date: 2008-01-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.09 Å) Cite: The crystal structure of possible transcriptional regulator YydK from Bacillus subtilis subsp. subtilis str. 168. To be Published
4M3B	Rapid and efficient design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging and linking approaches Descriptor: 4-(2-methyl-1,3-thiazol-4-yl)-N-(3,3,3-trifluoropropyl)benzamide, HTH-type transcriptional regulator EthR Authors: Villemagne, B, Flipo, M, Blondiaux, N, Crauste, C, Malaquin, S, Leroux, F, Piveteau, C, Villeret, V, Brodin, P, Villoutreix, B, Sperandio, O, Wohlkonig, A, Wintjens, R, Deprez, B, Baulard, A, Willand, N. Deposit date: 2013-08-06 Release date: 2014-06-25 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.001 Å) Cite: Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches. J.Med.Chem., 57, 2014
8ZLD	Crystal structure of PfHO from Plasmodium falciparum at 2.78 A Descriptor: Heme oxygenase, SULFATE ION Authors: Caaveiro, J.M.M, Senoo, A. Deposit date: 2024-05-18 Release date: 2024-09-04 Method: X-RAY DIFFRACTION (2.78 Å) Cite: Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis Elife, 2024
9CK0	Cocrystal of PPARg LBD and NFKBIB / IKBB peptide with agonist GW1929 Descriptor: (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid, NF-kappa-B inhibitor beta, Peroxisome proliferator-activated receptor gamma Authors: Nemetchek, M.D, McClelland, L.J, Hughes, T.S. Deposit date: 2024-07-08 Release date: 2024-07-17 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Cocrystal of PPARg LBD with NFKBIB / IKBB peptide containing N-anchor motif LxxLL and agonist GW1929 To Be Published
9CWN	NRIP1_133 / RIP140 SxxLxxLL motif coregulator peptide with agonist GW1929 and PPARg LBD Descriptor: (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid, Nuclear receptor-interacting protein 1, Peroxisome proliferator-activated receptor gamma Authors: Nemetchek, M.D, Voss, A.H, McClelland, L.J, Hughes, T.S. Deposit date: 2024-07-29 Release date: 2024-08-14 Method: X-RAY DIFFRACTION (2.7 Å) Cite: NRIP1_133 / RIP140 SxxLxxLL motif coregulator peptide with agonist GW1929 and PPARg LBD To Be Published
3LFS	Crystal structure of CDK2 with SAR37, an aminoindazole type inhibitor Descriptor: Cell division protein kinase 2, N-(6-chloro-5-phenyl-1H-indazol-3-yl)butanamide Authors: Dreyer, M.K, Wendt, K.U, Schimanski-Breves, S, Loenze, P. Deposit date: 2010-01-18 Release date: 2010-03-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg.Med.Chem.Lett., 20, 2010
4R7A	Crystal Structure of RBBP4 bound to PHF6 peptide Descriptor: GLYCEROL, Histone-binding protein RBBP4, PHD finger protein 6 Authors: Liu, Z, Li, F, Zhang, B, Li, S, Wu, J, Shi, Y. Deposit date: 2014-08-27 Release date: 2015-01-14 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural Basis of Plant Homeodomain Finger 6 (PHF6) Recognition by the Retinoblastoma Binding Protein 4 (RBBP4) Component of the Nucleosome Remodeling and Deacetylase (NuRD) Complex J.Biol.Chem., 290, 2015
5EIZ	Crystal structure of Y99A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2015-10-30 Release date: 2015-11-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74. Angew. Chem. Int. Ed. Engl., 2018
3LFQ	Crystal structure of CDK2 with SAR60, an aminoindazole type inhibitor Descriptor: Cell division protein kinase 2, N-(6,7-difluoro-5-phenyl-1H-indazol-3-yl)butanamide Authors: Dreyer, M.K, Wendt, K.U, Schimanski-Breves, S, Loenze, P. Deposit date: 2010-01-18 Release date: 2010-03-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg.Med.Chem.Lett., 20, 2010
3LFN	Crystal structure of CDK2 with SAR57, an aminoindazole type inhibitor Descriptor: Cell division protein kinase 2, N-[6-(4-hydroxyphenyl)-5-phenyl-1H-indazol-3-yl]butanamide Authors: Dreyer, M.K, Wendt, K.U, Schimanski-Breves, S, Loenze, P. Deposit date: 2010-01-18 Release date: 2010-03-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg.Med.Chem.Lett., 20, 2010
3LE6	The structure of cyclin dependent kinase 2 (CKD2) with a pyrazolobenzodiazepine inhibitor Descriptor: 5-(2-chlorophenyl)-3-methyl-7-nitropyrazolo[3,4-b][1,4]benzodiazepine, Cell division protein kinase 2 Authors: Lukacs, C.M, Swain, A, Crowther, R.L, Kammlott, R.U, Liu, J.J. Deposit date: 2010-01-14 Release date: 2010-11-17 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2 Å) Cite: Pyrazolobenzodiazepines: part I. Synthesis and SAR of a potent class of kinase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
7KD8	TtgR C137I I141W M167L F168Y mutant in complex with resveratrol Descriptor: HTH-type transcriptional regulator TtgR, MAGNESIUM ION, RESVERATROL Authors: Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S. Deposit date: 2020-10-08 Release date: 2021-10-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Epistasis shapes the fitness landscape of an allosteric specificity switch. Nat Commun, 12, 2021
7K1A	TtgR quadruple mutant (C137I I141W M167L F168Y) Descriptor: HTH-type transcriptional regulator TtgR, MAGNESIUM ION Authors: Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S. Deposit date: 2020-09-07 Release date: 2021-10-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Epistasis shapes the fitness landscape of an allosteric specificity switch. Nat Commun, 12, 2021
4WKM	AmpR effector binding domain from Citrobacter freundii bound to UDP-MurNAc-pentapeptide Descriptor: ALA-FGA-API-DAL-DAL, GLYCEROL, LysR family transcriptional regulator, ... Authors: Vadlamani, G, Reeve, T.M, Mark, B.L. Deposit date: 2014-10-02 Release date: 2014-12-17 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.15 Å) Cite: The beta-Lactamase Gene Regulator AmpR Is a Tetramer That Recognizes and Binds the d-Ala-d-Ala Motif of Its Repressor UDP-N-acetylmuramic Acid (MurNAc)-pentapeptide. J.Biol.Chem., 290, 2015
7K1C	TtgR in complex with resveratrol Descriptor: HTH-type transcriptional regulator TtgR, MAGNESIUM ION, RESVERATROL Authors: Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S. Deposit date: 2020-09-07 Release date: 2021-10-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Epistasis shapes the fitness landscape of an allosteric specificity switch. Nat Commun, 12, 2021
4WVY	Double-heterohexameric rings of full-length Rvb1(ATP)/Rvb2(apo) Descriptor: ADENOSINE-5'-TRIPHOSPHATE, RuvB-like 1, RuvB-like 2 Authors: Hopfner, K.-P, Lakomek, K. Deposit date: 2014-11-08 Release date: 2015-02-18 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.64 Å) Cite: Structural Basis for Dodecameric Assembly States and Conformational Plasticity of the Full-Length AAA+ ATPases Rvb1Rvb2. Structure, 23, 2015
6QDV	Human post-catalytic P complex spliceosome Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Fica, S.M, Oubridge, C, Wilkinson, M.E, Newman, A.J, Nagai, K. Deposit date: 2019-01-03 Release date: 2019-02-20 Last modified: 2024-09-11 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation. Science, 363, 2019
7UX2	cryo-EM structure of the Raptor-TFEB-Rag-Ragulator complex Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Cui, Z, Hurley, J. Deposit date: 2022-05-04 Release date: 2022-11-30 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature, 614, 2023
3MY5	CDk2/cyclinA in complex with DRB Descriptor: 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole, Cell division protein kinase 2, Cyclin-A2, ... Authors: Baumli, S, Johnson, L.N. Deposit date: 2010-05-09 Release date: 2010-09-29 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Halogen bonds form the basis for selective P-TEFb inhibition by DRB Chem.Biol., 17, 2010
8FLA	Human nuclear pre-60S ribosomal subunit (State K1) Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Vanden Broeck, A, Klinge, S. Deposit date: 2022-12-21 Release date: 2023-07-12 Last modified: 2023-07-26 Method: ELECTRON MICROSCOPY (2.63 Å) Cite: Principles of human pre-60 S biogenesis. Science, 381, 2023
8FL7	Human nuclear pre-60S ribosomal subunit (State J2) Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Vanden Broeck, A, Klinge, S. Deposit date: 2022-12-21 Release date: 2023-07-12 Last modified: 2023-07-26 Method: ELECTRON MICROSCOPY (2.55 Å) Cite: Principles of human pre-60 S biogenesis. Science, 381, 2023
8FLE	Human nuclear pre-60S ribosomal subunit (State L2) Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Vanden Broeck, A, Klinge, S. Deposit date: 2022-12-21 Release date: 2023-07-12 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (2.48 Å) Cite: Principles of human pre-60 S biogenesis. Science, 381, 2023
8FLB	Human nuclear pre-60S ribosomal subunit (State K2) Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Vanden Broeck, A, Klinge, S. Deposit date: 2022-12-21 Release date: 2023-07-12 Last modified: 2023-07-26 Method: ELECTRON MICROSCOPY (2.55 Å) Cite: Principles of human pre-60 S biogenesis. Science, 381, 2023

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