3LFS

Crystal structure of CDK2 with SAR37, an aminoindazole type inhibitor

Summary for 3LFS

Related3FLN 3LFQ
DescriptorCell division protein kinase 2, N-(6-chloro-5-phenyl-1H-indazol-3-yl)butanamide (3 entities in total)
Functional Keywordsprotein kinase fold, acetylation, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight34290.27
Authors
Dreyer, M.K.,Wendt, K.U.,Schimanski-Breves, S.,Loenze, P. (deposition date: 2010-01-18, release date: 2010-03-02, Last modification date: 2011-07-13)
Primary citation
Lesuisse, D.,Dutruc-Rosset, G.,Tiraboschi, G.,Dreyer, M.K.,Maignan, S.,Chevalier, A.,Halley, F.,Bertrand, P.,Burgevin, M.C.,Quarteronet, D.,Rooney, T.
Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.
Bioorg.Med.Chem.Lett., 20:1985-1989, 2010
PubMed: 20167481 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2010.01.114
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26240.7%12.9%3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report