2BBU
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2CIA
| human nck2 sh2-domain in complex with a decaphosphopeptide from translocated intimin receptor (tir) of epec | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CYTOPLASMIC PROTEIN NCK2, ISOPROPYL ALCOHOL, ... | Authors: | Frese, S, Schubert, W.-D, Findeis, A.C, Marquardt, T, Roske, Y.S, Stradal, T.E.B, Heinz, D.W. | Deposit date: | 2006-03-17 | Release date: | 2006-04-24 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The Phosphotyrosine Peptide Binding Specificity of Nck1 and Nck2 Src Homology 2 Domains. J.Biol.Chem., 281, 2006
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2CI8
| sh2 domain of human nck1 adaptor protein - uncomplexed | Descriptor: | CYTOPLASMIC PROTEIN NCK1, PENTAETHYLENE GLYCOL, SULFATE ION | Authors: | Frese, S, Schubert, W.-D, Findeis, A.C, Marquardt, T, Roske, Y.S, Stradal, T.E.B, Heinz, D.W. | Deposit date: | 2006-03-17 | Release date: | 2006-04-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Phosphotyrosine Peptide Binding Specificity of Nck1 and Nck2 Src Homology 2 Domains. J.Biol.Chem., 281, 2006
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2CRH
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2CI9
| Nck1 SH2-domain in complex with a dodecaphosphopeptide from EPEC protein Tir | Descriptor: | CYTOPLASMIC PROTEIN NCK1, TRANSLOCATED INTIMIN RECEPTOR | Authors: | Frese, S, Schubert, W.-D, Findeis, A.C, Marquardt, T, Roske, Y.S, Stradal, T.E.B, Heinz, D.W. | Deposit date: | 2006-03-17 | Release date: | 2006-04-24 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The Phosphotyrosine Peptide Binding Specificity of Nck1 and Nck2 Src Homology 2 Domains. J.Biol.Chem., 281, 2006
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2CS0
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2CR4
| Solution structure of the SH2 domain of human SH3BP2 protein | Descriptor: | SH3 domain-binding protein 2 | Authors: | Hatta, R, Tomizawa, T, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-05-20 | Release date: | 2005-11-20 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the SH2 domain of human SH3BP2 protein To be Published
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2DM0
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2DX0
| Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2 | Descriptor: | Phospholipase C, gamma 2, SULFATE ION | Authors: | Handa, N, Takagi, T, Murayama, K, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-08-22 | Release date: | 2007-09-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2 To be Published
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2DLZ
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2DLY
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2DCR
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2EKX
| Solution structure of the human BMX SH2 domain | Descriptor: | Cytoplasmic tyrosine-protein kinase BMX | Authors: | Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-03-26 | Release date: | 2007-10-02 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the human BMX SH2 domain To be Published
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2EO3
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2ECD
| Solution structure of the human ABL2 SH2 domain | Descriptor: | Tyrosine-protein kinase ABL2 | Authors: | Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-02-13 | Release date: | 2008-02-19 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the human ABL2 SH2 domain To be Published
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2EOB
| Solution structure of the second SH2 domain from rat PLC gamma-2 | Descriptor: | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 | Authors: | Sano, R, Hayashi, F, Nagashima, T, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-03-29 | Release date: | 2008-04-01 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the second SH2 domain from rat PLC gamma-2 To be Published
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2EO6
| Solution structure of the SH2 domain from mouse B-cell linker protein BLNK | Descriptor: | B-cell linker protein | Authors: | Sano, R, Hayashi, F, Kurosaki, C, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-03-29 | Release date: | 2008-04-01 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the SH2 domain from mouse B-cell linker protein BLNK To be Published
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2EYV
| SH2 domain of CT10-Regulated Kinase | Descriptor: | v-crk sarcoma virus CT10 oncogene homolog isoform a | Authors: | Kobashigawa, Y, Tanaka, S, Inagaki, F. | Deposit date: | 2005-11-10 | Release date: | 2006-11-10 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. Nat.Struct.Mol.Biol., 14, 2007
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2ETZ
| The NMR minimized average structure of the Itk SH2 domain bound to a phosphopeptide | Descriptor: | Lymphocyte cytosolic protein 2 phosphopeptide fragment, Tyrosine-protein kinase ITK/TSK | Authors: | Sundd, M, Pletneva, E.V, Fulton, D.B, Andreotti, A.H. | Deposit date: | 2005-10-27 | Release date: | 2006-02-07 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Molecular Details of Itk Activation by Prolyl Isomerization and Phospholigand Binding: The NMR Structure of the Itk SH2 Domain Bound to a Phosphopeptide. J.Mol.Biol., 357, 2006
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2EU0
| The NMR ensemble structure of the Itk SH2 domain bound to a phosphopeptide | Descriptor: | Lymphocyte cytosolic protein 2 phosphopeptide fragment, Tyrosine-protein kinase ITK/TSK | Authors: | Sundd, M, Pletneva, E.V, Fulton, D.B, Andreotti, A.H. | Deposit date: | 2005-10-27 | Release date: | 2006-02-07 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Molecular Details of Itk Activation by Prolyl Isomerization and Phospholigand Binding: The NMR Structure of the Itk SH2 Domain Bound to a Phosphopeptide. J.Mol.Biol., 357, 2006
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2FCI
| Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase | Descriptor: | C-termainl SH2 domain from phospholipase C-gamma-1 comprising residues 663-759, Doubly phosphorylated peptide derived from Syk kinase comprising residues 338-350 | Authors: | Groesch, T.D, Zhou, F, Mattila, S, Geahlen, R.L, Post, C.B. | Deposit date: | 2005-12-12 | Release date: | 2006-01-31 | Last modified: | 2023-11-15 | Method: | SOLUTION NMR | Cite: | Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by syk tyrosine kinase J.Mol.Biol., 356, 2006
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2GE9
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1O4B
| CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU83876. | Descriptor: | N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-3,4-DIPHOSPHONOPHENYLALANINAMIDE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | Authors: | Lange, G, Loenze, P, Liesum, A. | Deposit date: | 2003-06-15 | Release date: | 2004-02-17 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1O42
| CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU81843. | Descriptor: | N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-O-PHOSPHONOTYROSINAMIDE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | Authors: | Lange, G, Loenze, P, Liesum, A. | Deposit date: | 2003-06-15 | Release date: | 2004-02-17 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1O4E
| CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78299. | Descriptor: | 2,6-DIFORMYL-4-METHYLPHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | Authors: | Lange, G, Loenze, P, Liesum, A. | Deposit date: | 2003-06-15 | Release date: | 2004-02-17 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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