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3G1A	Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 6-azauridine 5'-monophosphate Descriptor: 6-AZA URIDINE 5'-MONOPHOSPHATE, Orotidine 5'-phosphate decarboxylase Authors: Fedorov, A.A, Fedorov, E.V, Chan, K.K, Gerlt, J.A, Almo, S.C. Deposit date: 2009-01-29 Release date: 2009-06-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization. Biochemistry, 48, 2009
3MI2	Crystal structure of human orotidine-5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate Descriptor: (1S)-1,4-anhydro-1-(5-carbamoyl-4-hydroxy-1H-pyrazol-3-yl)-5-O-phosphono-D-ribitol, Uridine 5'-monophosphate synthase Authors: Liu, Y, To, T, Kotra, L.P, Pai, E.F. Deposit date: 2010-04-09 Release date: 2010-05-26 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase. Bioorg.Med.Chem., 18, 2010
3M5Z	Crystal structure of the mutant V182A,I218A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum Descriptor: Orotidine 5'-phosphate decarboxylase, SULFATE ION Authors: Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. Deposit date: 2010-03-14 Release date: 2010-06-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
3KVM	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 951 at 2.00A resolution Descriptor: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, 2-[(2E)-2-{[5-(2-chlorophenyl)furan-2-yl]methylidene}hydrazino]benzoic acid, ACETATE ION, ... Authors: McLean, L, Zhang, Y. Deposit date: 2009-11-30 Release date: 2010-03-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures. Bioorg.Med.Chem.Lett., 20, 2010
3L0K	Human orotidyl-5'-monophosphate decarboxylase in complex with 6-acetyl-UMP Descriptor: 6-acetyluridine 5'-phosphate, GLYCEROL, Uridine 5'-monophosphate synthase Authors: Heinrich, D, Diederichsen, U, Rudolph, M. Deposit date: 2009-12-10 Release date: 2010-01-26 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.34 Å) Cite: Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase Chemistry, 15, 2009
3KVL	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 715 at 1.85A resolution Descriptor: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, 5-[methyl(pyridin-3-ylmethyl)amino]-2-(propanoylamino)benzoic acid, ACETATE ION, ... Authors: McLean, L, Zhang, Y. Deposit date: 2009-11-30 Release date: 2010-03-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures. Bioorg.Med.Chem.Lett., 20, 2010
3GZ3	Leishmania major Dihydroorotate Dehydrogenase in complex with orotate Descriptor: Dihydroorotate dehydrogenase, putative, FLAVIN MONONUCLEOTIDE, ... Authors: Cordeiro, A.T, Feliciano, P.R, Nonato, M.C. Deposit date: 2009-04-06 Release date: 2010-04-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Leismania major dihydroorotate in complex with orotate To be Published
3M41	Crystal structure of the mutant V182A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum Descriptor: GLYCEROL, Orotidine 5'-phosphate decarboxylase Authors: Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. Deposit date: 2010-03-10 Release date: 2010-06-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
3GZH	Crystal structure of phosphate-bound adenylosuccinate lyase from E. coli Descriptor: Adenylosuccinate lyase, PHOSPHATE ION, SODIUM ION Authors: Kozlov, G, Gehring, K, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) Deposit date: 2009-04-07 Release date: 2009-08-25 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The structure of phosphate-bound Escherichia coli adenylosuccinate lyase identifies His171 as a catalytic acid. Acta Crystallogr.,Sect.F, 65, 2009
1PL0	Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC Descriptor: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, Bifunctional purine biosynthesis protein PURH, N-(4-{[(2-AMINO-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO]SULFONYL}BENZOYL)GLUTAMIC ACID, ... Authors: Cheong, C.G, Greasley, S.E, Horton, P.A, Beardsley, G.P, Wilson, I.A. Deposit date: 2003-06-06 Release date: 2004-04-27 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal Structures of Human Bifunctional Enzyme Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase in Complex with Potent Sulfonyl-containing Antifolates. J.Biol.Chem., 279, 2004
3MJD	1.9 Angstrom Crystal Structure of Orotate Phosphoribosyltransferase (pyrE) Francisella tularensis. Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Orotate phosphoribosyltransferase Authors: Minasov, G, Shuvalova, L, Dubrovska, I, Winsor, J, Papazisi, L, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2010-04-12 Release date: 2010-04-21 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: 1.9 Angstrom Crystal Structure of Orotate Phosphoribosyltransferase (pyrE) Francisella tularensis. TO BE PUBLISHED
3M5X	Crystal structure of the mutant V182A,I199A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum Descriptor: Orotidine 5'-phosphate decarboxylase Authors: Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. Deposit date: 2010-03-14 Release date: 2010-06-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
3MPU	Crystal structure of the C47A/A241C disulfide-linked E. coli Aspartate Transcarbamoylase holoenzyme Descriptor: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, PHOSPHATE ION, ... Authors: Mendes, K.R, Kantrowitz, E.R. Deposit date: 2010-04-27 Release date: 2010-07-21 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.855 Å) Cite: The Pathway of Product Release from the R State of Aspartate Transcarbamoylase. J.Mol.Biol., 401, 2010
3M1Z	Crystal structure of the mutant V182A.V201A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP Descriptor: 6-HYDROXYURIDINE-5'-PHOSPHATE, Orotidine 5'-phosphate decarboxylase Authors: Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. Deposit date: 2010-03-06 Release date: 2010-06-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.42 Å) Cite: Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
3M44	Crystal structure of the mutant V201A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum Descriptor: GLYCEROL, Orotidine 5'-phosphate decarboxylase Authors: Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. Deposit date: 2010-03-10 Release date: 2010-06-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
3MW7	Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-UMP(produced from 5-fluoro-6-amino-UMP) Descriptor: 5-FLUORO-URIDINE-5'-MONOPHOSPHATE, Uridine 5'-monophosphate synthase Authors: Liu, Y, Kotra, L.P, Pai, E.F. Deposit date: 2010-05-05 Release date: 2011-04-06 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-UMP(produced from 5-fluoro-6-amino-UMP) To be Published
3LTS	Crystal structure of the mutant V182A,I199A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP Descriptor: 6-HYDROXYURIDINE-5'-PHOSPHATE, Orotidine 5'-phosphate decarboxylase Authors: Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. Deposit date: 2010-02-16 Release date: 2010-06-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.428 Å) Cite: Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
3LHV	Crystal structure of the mutant V182A.I199A.V201A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP Descriptor: 1-(5'-PHOSPHO-BETA-D-RIBOFURANOSYL)BARBITURIC ACID, Orotidine 5'-phosphate decarboxylase Authors: Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. Deposit date: 2010-01-23 Release date: 2010-06-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
3N2L	2.1 Angstrom resolution crystal structure of an Orotate Phosphoribosyltransferase (pyrE) from Vibrio cholerae O1 biovar eltor str. N16961 Descriptor: CHLORIDE ION, Orotate phosphoribosyltransferase Authors: Halavaty, A.S, Minasov, G, Shuvalova, L, Dubrovska, I, Winsor, J, Kwon, K, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2010-05-18 Release date: 2010-06-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: 2.1 Angstrom resolution crystal structure of an Orotate Phosphoribosyltransferase (pyrE) from Vibrio cholerae O1 biovar eltor str. N16961 To be Published
3MO7	Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified by 2'-fluoro-6-iodo-UMP Descriptor: 2'-deoxy-2'-fluorouridine 5'-(dihydrogen phosphate), GLYCEROL, Uridine 5'-monophosphate synthase Authors: Liu, Y, Kotra, L.P, Pai, E.F. Deposit date: 2010-04-22 Release date: 2011-04-06 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase. J.Med.Chem., 54, 2011
3M5Y	Crystal structure of the mutant V182A,V201A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum Descriptor: FORMIC ACID, GLYCEROL, Orotidine 5'-phosphate decarboxylase Authors: Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. Deposit date: 2010-03-14 Release date: 2010-06-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.455 Å) Cite: Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
3M43	Crystal structure of the mutant I199A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum Descriptor: GLYCEROL, Orotidine 5'-phosphate decarboxylase Authors: Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. Deposit date: 2010-03-10 Release date: 2010-06-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
3GYE	Didydroorotate dehydrogenase from Leishmania major Descriptor: Dihydroorotate dehydrogenase, putative, FLAVIN MONONUCLEOTIDE, ... Authors: Cordeiro, A.T, Feliciano, P.R, Nonato, M.C. Deposit date: 2009-04-03 Release date: 2010-04-07 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structure of Leishmania major Dihydroorotate dehydrogenase To be Published
3MWA	Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase covalently modified by 2-prime-fluoro-6-iodo-UMP Descriptor: 2'-deoxy-2'-fluorouridine 5'-(dihydrogen phosphate), DI(HYDROXYETHYL)ETHER, Orotidine 5'-phosphate decarboxylase, ... Authors: Liu, Y, Kotra, L.P, Pai, E.F. Deposit date: 2010-05-05 Release date: 2011-04-06 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase covalently modified by 2-prime-fluoro-6-iodo-UMP To be Published
3N2M	Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 6-amino-5-fluorouridine 5'-(dihydrogen phosphate), ... Authors: Liu, Y, Kotra, L.P, Pai, E.F. Deposit date: 2010-05-18 Release date: 2011-04-06 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP To be Published

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