3MI2

Crystal structure of human orotidine-5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate

Summary for 3MI2

Entry DOI	10.2210/pdb3mi2/pdb
Related	2EAW 2P1F 3BGG 3BGJ 3BKO 3BVJ 3G3D 3G3M
Descriptor	Uridine 5'-monophosphate synthase, (1S)-1,4-anhydro-1-(5-carbamoyl-4-hydroxy-1H-pyrazol-3-yl)-5-O-phosphono-D-ribitol (3 entities in total)
Functional Keywords	ump synthase, orotidine 5'-monophosphate decarboxylase, pyrazofurin monophosphate, lyase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	61686.72
Authors	Liu, Y.,To, T.,Kotra, L.P.,Pai, E.F. (deposition date: 2010-04-09, release date: 2010-05-26, Last modification date: 2023-09-06)
Primary citation	Meza-Avina, M.E.,Wei, L.,Liu, Y.,Poduch, E.,Bello, A.M.,Mishra, R.K.,Pai, E.F.,Kotra, L.P. Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase. Bioorg.Med.Chem., 18:4032-4041, 2010 Cited by PubMed: 20452222 DOI: 10.1016/j.bmc.2010.04.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation