3MI2

Crystal structure of human orotidine-5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Uridine 5'-monophosphate synthase	polymer	279	30504.2	2	UniProt (P11172) Pfam (PF00215)	Homo sapiens (human)	UMP synthase, Orotate phosphoribosyltransferase, OPRTase, Orotidine 5'-phosphate decarboxylase, OMPdecase
2	C, D (A, B)	(1S)-1,4-anhydro-1-(5-carbamoyl-4-hydroxy-1H-pyrazol-3-yl)-5-O-phosphono-D-ribitol	non-polymer		339.2	2	Chemie (PFU)
3	E, F (A, B)	water	water		18.0	692	Chemie (HOH)

Sequence modifications

A, B: 34 - 291 (UniProt: P11172)

PDB	External Database	Details
Met 13	-	expression tag
Gly 14	-	expression tag
Ser 15	-	expression tag
Ser 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
His 21	-	expression tag
His 22	-	expression tag
Ser 23	-	expression tag
Ser 24	-	expression tag
Gly 25	-	expression tag
Leu 26	-	expression tag
Val 27	-	expression tag
Pro 28	-	expression tag
Arg 29	-	expression tag
Gly 30	-	expression tag
Ser 31	-	expression tag
His 32	-	expression tag
Met 33	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	61008.3
Non-Polymers*	Number of molecules	2
	Total formula weight	678.4
All*	Total formula weight	61686.7

*Water molecules are not included.