3OJ4
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6UMP
| Crystal structure of MavC in complex with substrate mimic in P65 space group | Descriptor: | MavC, Ubiquitin, Ubiquitin-conjugating enzyme E2 N | Authors: | Puvar, K, Iyer, S, Luo, Z.Q, Das, C. | Deposit date: | 2019-10-10 | Release date: | 2020-05-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination. Nat Commun, 11, 2020
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5HPT
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5IFR
| Structure of the stable UBE2D3-UbDha conjugate | Descriptor: | GLYCEROL, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D3 | Authors: | Pruneda, J.N, Mulder, M.P.C, Witting, K, Ovaa, H, Komander, D. | Deposit date: | 2016-02-26 | Release date: | 2016-05-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes. Nat.Chem.Biol., 12, 2016
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7UN3
| Complex of UBE2O with NAP1L1 and ubiquitylated uL2 | Descriptor: | Nucleosome assembly protein 1-like 1, Ubiquitin,60S ribosomal protein L8,(E3-independent) E2 ubiquitin-conjugating enzyme fusion | Authors: | Yip, M.C.J, Sedor, S.F, Shao, S. | Deposit date: | 2022-04-08 | Release date: | 2022-08-03 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Mechanism of client selection by the protein quality-control factor UBE2O. Nat.Struct.Mol.Biol., 29, 2022
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7UN6
| Complex of UBE2O with NAP1L1 | Descriptor: | (E3-independent) E2 ubiquitin-conjugating enzyme, Nucleosome assembly protein 1-like 1 | Authors: | Yip, M.C.J, Sedor, S.F, Shao, S. | Deposit date: | 2022-04-09 | Release date: | 2022-08-03 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mechanism of client selection by the protein quality-control factor UBE2O. Nat.Struct.Mol.Biol., 29, 2022
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6W7Z
| RNF12 RING domain in complex with Ube2d2 | Descriptor: | E3 ubiquitin-protein ligase RLIM, GLYCEROL, Ubiquitin-conjugating enzyme E2 D2, ... | Authors: | Middleton, A.J, Day, C.L. | Deposit date: | 2020-03-19 | Release date: | 2020-05-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The RING Domain of RING Finger 12 Efficiently Builds Degradative Ubiquitin Chains. J.Mol.Biol., 432, 2020
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6W9A
| RNF12 RING domain in complex with Ube2e2 | Descriptor: | E3 ubiquitin-protein ligase RLIM, GLYCEROL, Ubiquitin-conjugating enzyme E2 E2, ... | Authors: | Middleton, A.J, Day, C.L. | Deposit date: | 2020-03-22 | Release date: | 2020-05-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The RING Domain of RING Finger 12 Efficiently Builds Degradative Ubiquitin Chains. J.Mol.Biol., 432, 2020
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5FER
| Complex of TRIM25 RING with UbcH5-Ub | Descriptor: | E3 ubiquitin/ISG15 ligase TRIM25, Ubiquitin-40S ribosomal protein S27a, Ubiquitin-conjugating enzyme E2 D1, ... | Authors: | Rittinger, K, Koliopoulos, M.G, Esposito, D. | Deposit date: | 2015-12-17 | Release date: | 2016-05-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity. Embo J., 35, 2016
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6W9D
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6P5B
| Crystal Structure of MavC in Complex with Ub-UbE2N | Descriptor: | MavC, Ubiquitin, Ubiquitin-conjugating enzyme E2 N | Authors: | Puvar, K, Iyer, S, Negron Teron, K.I, Das, C. | Deposit date: | 2019-05-30 | Release date: | 2020-05-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination. Nat Commun, 11, 2020
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1TTE
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5KHR
| Model of human Anaphase-promoting complex/Cyclosome complex (APC15 deletion mutant) in complex with the E2 UBE2C/UBCH10 poised for ubiquitin ligation to substrate (APC/C-CDC20-substrate-UBE2C) | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | VanderLinden, R, Yamaguchi, M, Dube, P, Haselbach, D, Stark, H, Schulman, B.A. | Deposit date: | 2016-06-15 | Release date: | 2016-08-24 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (6.1 Å) | Cite: | Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation. Mol.Cell, 63, 2016
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8GCB
| Structure of RNF125 in complex with a UbcH5b~Ub conjugate | Descriptor: | E3 ubiquitin-protein ligase RNF125, Ubiquitin-conjugating enzyme E2 D2, ZINC ION | Authors: | Middleton, A.J, Day, C.L, Fokkens, T.J. | Deposit date: | 2023-03-01 | Release date: | 2023-07-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Zinc finger 1 of the RING E3 ligase, RNF125, interacts with the E2 to enhance ubiquitylation. Structure, 31, 2023
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8GBQ
| Structure of RNF125 in complex with UbcH5b | Descriptor: | E3 ubiquitin-protein ligase RNF125, GLYCEROL, Ubiquitin-conjugating enzyme E2 D2, ... | Authors: | Middleton, A.J, Day, C.L, Fokkens, T.J. | Deposit date: | 2023-02-27 | Release date: | 2023-07-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Zinc finger 1 of the RING E3 ligase, RNF125, interacts with the E2 to enhance ubiquitylation. Structure, 31, 2023
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5KNL
| Crystal structure of S. pombe ubiquitin E1 (Uba1) in complex with Ubc15 and ubiquitin | Descriptor: | SULFATE ION, Ubiquitin, Ubiquitin-activating enzyme E1 1, ... | Authors: | Olsen, S.K, Lv, Z, Yuan, L, Williams, K. | Deposit date: | 2016-06-28 | Release date: | 2017-02-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity. Mol. Cell, 65, 2017
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5L9U
| Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. | Deposit date: | 2016-06-11 | Release date: | 2016-09-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
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5L9T
| Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A. | Deposit date: | 2016-06-11 | Release date: | 2016-10-26 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
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7XED
| Crystal Structure of OsCIE1-Ubox and OsUBC8 complex | Descriptor: | U-box domain-containing protein 12, UBC core domain-containing protein | Authors: | Zhang, Y, Yu, C.Z. | Deposit date: | 2022-03-30 | Release date: | 2023-10-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice Nature, 2024
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1UR6
| NMR based structural model of the UbcH5B-CNOT4 complex | Descriptor: | POTENTIAL TRANSCRIPTIONAL REPRESSOR NOT4HP, UBIQUITIN-CONJUGATING ENZYME E2-17 KDA 2, ZINC ION | Authors: | Dominguez, C, Bonvin, A.M.J.J, Winkler, G.S, Van Schaik, F.M.A, Timmers, H.Th.M, Boelens, R. | Deposit date: | 2003-10-27 | Release date: | 2004-05-07 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR, THEORETICAL MODEL | Cite: | Structural Model of the Ubch5B/Cnot4 Complex Revealed by Combining NMR, Mutagenesis, and Docking Approaches. Structure, 12, 2004
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5MNJ
| Structure of MDM2-MDMX-UbcH5B-ubiquitin complex | Descriptor: | E3 ubiquitin-protein ligase Mdm2, Polyubiquitin-B, Protein Mdm4, ... | Authors: | Klejnot, M, Huang, D.T. | Deposit date: | 2016-12-13 | Release date: | 2017-05-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity. Nat. Struct. Mol. Biol., 24, 2017
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4W5V
| Crystal structure of Human SUMO E2-conjugating enzyme (Ubc9) in complex with E1-activating enzyme (Uba2) ubiquitin fold domain (Ufd) | Descriptor: | FORMIC ACID, GLYCEROL, POTASSIUM ION, ... | Authors: | Boucher, L.E, Reiter, K.H, Matunis, M.J, Bosch, J. | Deposit date: | 2014-08-19 | Release date: | 2015-09-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of human SUMO complex To Be Published
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4V3L
| RNF38-UB-UbcH5B-Ub complex | Descriptor: | 1,2-ETHANEDIOL, E3 UBIQUITIN-PROTEIN LIGASE RNF38, POLYUBIQUITIN-C, ... | Authors: | Buetow, L, Gabrielsen, M, Anthony, N.G, Dou, H, Patel, A, Aitkenhead, H, Sibbet, G.J, Smith, B.O, Huang, D.T. | Deposit date: | 2014-10-20 | Release date: | 2015-04-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin. Mol.Cell, 58, 2015
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4V3K
| RNF38-UbcH5B-UB complex | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ... | Authors: | Buetow, L, Gabrielsen, M, Anthony, N.G, Dou, H, Patel, A, Aitkenhead, H, Sibbet, G.J, Smith, B.O, Huang, D.T. | Deposit date: | 2014-10-20 | Release date: | 2015-04-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin. Mol.Cell, 58, 2015
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4JQU
| Crystal structure of Ubc7p in complex with the U7BR of Cue1p | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Coupling of ubiquitin conjugation to ER degradation protein 1, DI(HYDROXYETHYL)ETHER, ... | Authors: | Liang, Y.-H, Metzger, M.B, Weissman, A.M, Ji, X. | Deposit date: | 2013-03-20 | Release date: | 2013-05-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | A Structurally Unique E2-Binding Domain Activates Ubiquitination by the ERAD E2, Ubc7p, through Multiple Mechanisms. Mol.Cell, 50, 2013
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