3FZI
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3HIK
| Structure of human Plk1-PBD in complex with PLHSpT | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Pentamer phosphopeptide, ... | Authors: | Wlodawer, A, Moulaei, T. | Deposit date: | 2009-05-20 | Release date: | 2009-06-09 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat.Struct.Mol.Biol., 16, 2009
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3QLY
| Candida glabrata dihydrofolate reductase complexed with NADPH and 6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP115A) | Descriptor: | 6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Strain CBS138 chromosome J complete sequence | Authors: | Paulsen, J.L, Bendel, S.D, Anderson, A.C. | Deposit date: | 2011-02-03 | Release date: | 2011-07-20 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.519 Å) | Cite: | Crystal Structures of Candida albicans Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal the Flexibility of Active Site Loop Residues Critical for Ligand Potency and Selectivity. Chem.Biol.Drug Des., 78, 2011
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3HJA
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3HJF
| Crystal structure of T. thermophilus Argonaute E546 mutant protein complexed with DNA guide strand and 15-nt RNA target strand | Descriptor: | 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ... | Authors: | Wang, Y, Li, H, Sheng, G, Patel, D.J. | Deposit date: | 2009-05-21 | Release date: | 2009-10-06 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.056 Å) | Cite: | Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature, 461, 2009
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3HDZ
| Identification, Synthesis, and SAR of Amino Substituted Pyrido[3,2b]pryaziones as Potent and Selective PDE5 Inhibitors | Descriptor: | 5-amino-1-butyl-7-phenyl-1,6-naphthyridin-4(1H)-one, MAGNESIUM ION, ZINC ION, ... | Authors: | Cubbage, J.W, Brown, D.G, Jacobsen, E.J, Walker, J.K, Hughes, R.O. | Deposit date: | 2009-05-07 | Release date: | 2009-07-07 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
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3Q5J
| Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K213 in the presence of 17-DMAP-geldanamycin | Descriptor: | (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-{[3-(dimethylamino)propyl]amino}-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate, Heat shock protein 83-1 | Authors: | Wernimont, A.K, Tempel, W, Lin, Y.H, Hutchinson, A, MacKenzie, F, Fairlamb, A, Cossar, D, Zhao, Y, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Ferguson, M.A.J, Hui, R, Pizarro, J.C, Hills, T, Structural Genomics Consortium (SGC) | Deposit date: | 2010-12-28 | Release date: | 2011-02-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K213 in the presence of 17-DMAP-geldanamycin. To be Published
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3QKP
| Protein Tyrosine Phosphatase 1B - Apo W179F mutant with open WPD-loop | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Brandao, T.A.S, Johnson, S.J, Hengge, A.C. | Deposit date: | 2011-02-01 | Release date: | 2012-08-08 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch.Biochem.Biophys., 525, 2012
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3HFD
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3QLA
| Hexagonal complex structure of ATRX ADD bound to H3K9me3 peptide | Descriptor: | POTASSIUM ION, Transcriptional regulator ATRX, ZINC ION, ... | Authors: | Xiang, B, Li, H. | Deposit date: | 2011-02-02 | Release date: | 2011-06-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome Nat.Struct.Mol.Biol., 18, 2011
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3QLK
| Crystal Structure of RipA from Yersinia pestis | Descriptor: | Coenzyme A transferase | Authors: | Torres, R, Goulding, C.W. | Deposit date: | 2011-02-02 | Release date: | 2012-01-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Biochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis. Plos One, 6, 2011
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3HFO
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3QM0
| Crystal structure of RTT109-AC-CoA complex | Descriptor: | ACETYL COENZYME *A, Histone acetyltransferase RTT109, MERCURY (II) ION | Authors: | Tang, Y, Marmorstein, R. | Deposit date: | 2011-02-03 | Release date: | 2011-02-16 | Last modified: | 2017-08-02 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP. Nat.Struct.Mol.Biol., 15, 2008
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3HJX
| Human prion protein variant D178N with V129 | Descriptor: | CADMIUM ION, CHLORIDE ION, Major prion protein | Authors: | Lee, S, Antony, L, Hartmann, R, Knaus, K.J, Surewicz, K, Surewicz, W.K, Yee, V.C. | Deposit date: | 2009-05-22 | Release date: | 2010-01-12 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Conformational diversity in prion protein variants influences intermolecular beta-sheet formation. Embo J., 29, 2010
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3Q74
| Crystal Structure Analysis of the L7A Mutant of the Apo Form of Human Alpha Class Glutathione Transferase | Descriptor: | Glutathione S-transferase A1 | Authors: | Fanucchi, S, Achilonu, I.A, Khoza, T.N, Fernandes, M.A, Gildenhuys, S, Dirr, H.W. | Deposit date: | 2011-01-04 | Release date: | 2011-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Crystal Structure Analysis of the L7A Mutant of the Apo Form of Human Alpha Class Glutathione Transferase To be Published
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3Q8E
| Crystal structure of Protective Antigen W346F (pH 8.5) | Descriptor: | CALCIUM ION, Protective antigen | Authors: | Lovell, S, Battaile, K.P, Rajapaksha, M, Janowiak, B.E, Andra, K.K, Bann, J.G. | Deposit date: | 2011-01-06 | Release date: | 2012-02-15 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.098 Å) | Cite: | pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2. Protein Sci., 21, 2012
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3HG8
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3HGD
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3HK1
| Identification and Characterization of a Small Molecule Inhibitor of Fatty Acid Binding Proteins | Descriptor: | 4-{[2-(methoxycarbonyl)-5-(2-thienyl)-3-thienyl]amino}-4-oxo-2-butenoic acid, Fatty acid-binding protein, adipocyte | Authors: | Hertzel, A.V, Hellberg, K, Reynolds, J.M, Kruse, A.C, Juhlmann, B.E, Smith, A.J, Sanders, M.A, Ohlendorf, D.H, Suttles, J, Bernlohr, D.A. | Deposit date: | 2009-05-22 | Release date: | 2009-09-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins. J.Med.Chem., 52, 2009
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3QOU
| Crystal Structure of E. coli YbbN | Descriptor: | CALCIUM ION, protein ybbN | Authors: | Lin, J, Wilson, M.A. | Deposit date: | 2011-02-10 | Release date: | 2011-02-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Escherichia coli Thioredoxin-like Protein YbbN Contains an Atypical Tetratricopeptide Repeat Motif and Is a Negative Regulator of GroEL. J.Biol.Chem., 286, 2011
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3HJY
| Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA | Descriptor: | 5'-R(*GP*GP*AP*GP*CP*GP*UP*GP*CP*GP*GP*UP*UP*U)-3', 5'-R(*GP*GP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*CP*CP*GP*CP*GP*GP*CP*GP*C)-3', RNA (25-MER), ... | Authors: | Liang, B, Zhou, J, Kahen, E, Terns, R.M, Terns, M.P, Li, H. | Deposit date: | 2009-05-22 | Release date: | 2009-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.65 Å) | Cite: | Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA Nat.Struct.Mol.Biol., 16, 2009
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3Q9W
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3HJW
| Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA | Descriptor: | 5'-R(*GP*AP*GP*CP*GP*(FHU)P*GP*CP*GP*GP*UP*UP*U)-3', 50S ribosomal protein L7Ae, POTASSIUM ION, ... | Authors: | Liang, B, Zhou, J, Kahen, E, Terns, R.M, Terns, M.P, Li, H. | Deposit date: | 2009-05-22 | Release date: | 2009-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA Nat.Struct.Mol.Biol., 16, 2009
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3QS7
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3HK4
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