2LXZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2lxz by Molmil](/molmil-images/mine/2lxz) | Solution Structure of the Antimicrobial Peptide Human Defensin 5 | Descriptor: | Defensin-5 | Authors: | Wommack, A.J, Robson, S.A, Wanniarahchi, Y.A, Wan, A, Turner, C.J, Nolan, E.M. | Deposit date: | 2012-09-10 | Release date: | 2012-11-28 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | NMR solution structure and condition-dependent oligomerization of the antimicrobial Peptide human defensin 5. Biochemistry, 51, 2012
|
|
4MCS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4mcs by Molmil](/molmil-images/mine/4mcs) | A high resolution structure of human glutamate carboxypeptidase II (GCPII) His475Tyr variant in complex with glutamic acid | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ASPARTIC ACID, ... | Authors: | Ptacek, J, Barinka, C, Sacha, P, Navratil, M. | Deposit date: | 2013-08-21 | Release date: | 2014-06-18 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structural and biochemical characterization of the folyl-poly-gamma-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II. Febs J., 281, 2014
|
|
4MCP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4mcp by Molmil](/molmil-images/mine/4mcp) | A high resolution structure of human glutamate carboxypeptidase II (GCPII) in complex with folyl-gamma-L-glutamic acid (pteroyldi-gamma-L-glutamic acid) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Navratil, M, Barinka, C, Lubkowski, J. | Deposit date: | 2013-08-21 | Release date: | 2014-06-18 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural and biochemical characterization of the folyl-poly-gamma-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II. Febs J., 281, 2014
|
|
1ZFO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1zfo by Molmil](/molmil-images/mine/1zfo) | AMINO-TERMINAL LIM-DOMAIN PEPTIDE OF LASP-1, NMR | Descriptor: | LASP-1, ZINC ION | Authors: | Hammarstrom, A, Berndt, K.D, Sillard, R, Adermann, K, Otting, G. | Deposit date: | 1996-05-06 | Release date: | 1996-11-08 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Solution structure of a naturally-occurring zinc-peptide complex demonstrates that the N-terminal zinc-binding module of the Lasp-1 LIM domain is an independent folding unit. Biochemistry, 35, 1996
|
|
4JBT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4jbt by Molmil](/molmil-images/mine/4jbt) | |
4C66
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4c66 by Molmil](/molmil-images/mine/4c66) | Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains | Descriptor: | 4-(2-chlorophenyl)-2-ethyl-9-methyl-6,8-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, BROMODOMAIN-CONTAINING PROTEIN 4 | Authors: | Chung, C, Mirguet, O. | Deposit date: | 2013-09-17 | Release date: | 2013-10-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Discovery of Epigenetic Regulator I-Bet762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the Bet Bromodomains. J.Med.Chem., 56, 2013
|
|
4MCQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4mcq by Molmil](/molmil-images/mine/4mcq) | |
2OZ7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2oz7 by Molmil](/molmil-images/mine/2oz7) | Crystal structure of the human androgen receptor T877A mutant ligand-binding domain with cyproterone acetate | Descriptor: | Androgen receptor, CYPROTERONE ACETATE | Authors: | Bohl, C.E, Wu, Z, Miller, D.D, Bell, C.E, Dalton, J.T. | Deposit date: | 2007-02-25 | Release date: | 2007-03-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design. J.Biol.Chem., 282, 2007
|
|
4MCR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4mcr by Molmil](/molmil-images/mine/4mcr) | A high resolution structure of human glutamate carboxypeptidase II (GCPII) in complex with folyltri-gamma-L-glutamic acid (pteroyltetra-gamma-L-glutamic acid) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Navratil, M, Barinka, C, Lubkowski, J. | Deposit date: | 2013-08-21 | Release date: | 2014-06-18 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural and biochemical characterization of the folyl-poly-gamma-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II. Febs J., 281, 2014
|
|
1Y9O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1y9o by Molmil](/molmil-images/mine/1y9o) | 1H NMR Structure of Acylphosphatase from the hyperthermophile Sulfolobus Solfataricus | Descriptor: | Acylphosphatase | Authors: | Corazza, A, Rosano, C, Pagano, K, Alverdi, V, Esposito, G, Capanni, C, Bemporad, F, Plakoutsi, G, Stefani, M, Chiti, F, Zuccotti, S, Bolognesi, M, Viglino, P. | Deposit date: | 2004-12-16 | Release date: | 2005-11-29 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure, conformational stability, and enzymatic properties of acylphosphatase from the hyperthermophile Sulfolobus solfataricus Proteins, 62, 2006
|
|
1YDE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yde by Molmil](/molmil-images/mine/1yde) | Crystal Structure of Human Retinal Short-Chain Dehydrogenase/Reductase 3 | Descriptor: | Retinal dehydrogenase/reductase 3 | Authors: | Lukacik, P, Bunkozci, G, Kavanagh, K, Sundstrom, M, Arrowsmith, C, Edwards, A, von Delft, F, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2004-12-23 | Release date: | 2005-01-18 | Last modified: | 2012-03-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity. Biochem.J., 402, 2007
|
|
2AXN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2axn by Molmil](/molmil-images/mine/2axn) | Crystal structure of the human inducible form 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru- 2,6-P2ASE brain/placenta-type isozyme) (iPFK-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)], ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Kim, S.G, Manes, N.P, El-Maghrabi, M.R, Lee, Y.H. | Deposit date: | 2005-09-05 | Release date: | 2005-12-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy. J.Biol.Chem., 281, 2006
|
|
3TQ2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3tq2 by Molmil](/molmil-images/mine/3tq2) | |
8AXW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8axw by Molmil](/molmil-images/mine/8axw) | The structure of mouse AsterC (GramD1c) with Ezetimibe | Descriptor: | (3~{R},4~{S})-1-(4-fluorophenyl)-3-[(3~{S})-3-(4-fluorophenyl)-3-oxidanyl-propyl]-4-(4-hydroxyphenyl)azetidin-2-one, CHLORIDE ION, ETHANOL, ... | Authors: | Fairall, L, Xiao, X, Burger, L, Tontonoz, P, Schwabe, J.W.R. | Deposit date: | 2022-09-01 | Release date: | 2023-09-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake. Science, 382, 2023
|
|
7XV6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xv6 by Molmil](/molmil-images/mine/7xv6) | |
2W1B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2w1b by Molmil](/molmil-images/mine/2w1b) | The structure of the efflux pump AcrB in complex with bile acid | Descriptor: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, ACRIFLAVIN RESISTANCE PROTEIN B | Authors: | Drew, D, Klepsch, M.M, Newstead, S, Flaig, R, De Gier, J.W, Iwata, S, Beis, K. | Deposit date: | 2008-10-17 | Release date: | 2008-12-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.85 Å) | Cite: | The Structure of the Efflux Pump Acrb in Complex with Bile Acid. Mol.Membr.Biol., 25, 2008
|
|
2W6V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2w6v by Molmil](/molmil-images/mine/2w6v) | Structure of Human deoxy Hemoglobin A in complex with Xenon | Descriptor: | GLYCEROL, HEMOGLOBIN SUBUNIT ALPHA, HEMOGLOBIN SUBUNIT BETA, ... | Authors: | Miele, A.E, Draghi, F, Sciara, G, Johnson, K.A, Renzi, F, Vallone, B, Brunori, M, Savino, C. | Deposit date: | 2008-12-19 | Release date: | 2009-04-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Pattern of Cavities in Globins: The Case of Human Hemoglobin. Biopolymers, 91, 2009
|
|
2W72
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2w72 by Molmil](/molmil-images/mine/2w72) | DEOXYGENATED STRUCTURE OF A DISTAL SITE HEMOGLOBIN MUTANT PLUS XE | Descriptor: | HUMAN HEMOGLOBIN A, PHOSPHATE ION, POTASSIUM ION, ... | Authors: | Miele, A.E, Draghi, F, Sciara, G, Johnson, K.A, Renzi, F, Vallone, B, Brunori, M, Savino, C. | Deposit date: | 2008-12-19 | Release date: | 2009-04-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.07 Å) | Cite: | Pattern of Cavities in Globins: The Case of Human Hemoglobin. Biopolymers, 91, 2009
|
|
8CC7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8cc7 by Molmil](/molmil-images/mine/8cc7) | Mouse serotonin 5-HT3A receptor in complex with PZ-1939 | Descriptor: | 1-(3-chlorophenyl)sulfonyl-4-piperazin-1-yl-pyrrolo[3,2-c]quinoline, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lopez-Sanchez, U, Nury, H. | Deposit date: | 2023-01-26 | Release date: | 2023-10-11 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Superiority of the Triple-Acting 5-HT 6 R/5-HT 3 R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT 6 R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats. J.Med.Chem., 66, 2023
|
|
8CC6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8cc6 by Molmil](/molmil-images/mine/8cc6) | Mouse serotonin 5-HT3A receptor in complex with PZ-1922 | Descriptor: | 1-[(3-chlorophenyl)methyl]-4-piperazin-1-yl-pyrrolo[3,2-c]quinoline, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lopez-Sanchez, U, Nury, H. | Deposit date: | 2023-01-26 | Release date: | 2023-10-11 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Superiority of the Triple-Acting 5-HT 6 R/5-HT 3 R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT 6 R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats. J.Med.Chem., 66, 2023
|
|
1MY3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1my3 by Molmil](/molmil-images/mine/1my3) | crystal structure of glutamate receptor ligand-binding core in complex with bromo-willardiine in the Zn crystal form | Descriptor: | 2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, GLUTAMATE RECEPTOR 2, ZINC ION | Authors: | Jin, R, Gouaux, E. | Deposit date: | 2002-10-03 | Release date: | 2003-06-10 | Last modified: | 2017-08-23 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Probing the Function, Conformational Plasticity, and Dimer-Dimer Contacts of the GluR2 Ligand-Binding Core:
Studies of 5-Substituted Willardiines and GluR2 S1S2 in the Crystal Biochemistry, 42, 2003
|
|
1MY0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1my0 by Molmil](/molmil-images/mine/1my0) | crystal titration experiments (AMPA co-crystals soaked in 100 nM BrW) | Descriptor: | GLUTAMATE RECEPTOR 2, ZINC ION | Authors: | Jin, R, Gouaux, E. | Deposit date: | 2002-10-03 | Release date: | 2003-06-10 | Last modified: | 2017-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Probing the Function, Conformational Plasticity, and Dimer-Dimer Contacts of the GluR2 Ligand-Binding Core: Studies of 5-Substituted Willardiines and GluR2 S1S2 in the Crystal Biochemistry, 42, 2003
|
|
1MXU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1mxu by Molmil](/molmil-images/mine/1mxu) | CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) in complex with bromo-willardiine (Control for the crystal titration experiments) | Descriptor: | 2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, GLUTAMATE RECEPTOR 2, ZINC ION | Authors: | Jin, R, Gouaux, E. | Deposit date: | 2002-10-03 | Release date: | 2003-06-10 | Last modified: | 2017-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Probing the Function, Conformational Plasticity, and Dimer-Dimer Contacts of the GluR2 Ligand-Binding Core: Studies of 5-Substituted Willardiines and GluR2 S1S2 in the Crystal Biochemistry, 42, 2003
|
|
1MXY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1mxy by Molmil](/molmil-images/mine/1mxy) | crystal titration experiments (AMPA co-crystals soaked in 10 uM BrW) | Descriptor: | GLUTAMATE RECEPTOR 2, ZINC ION | Authors: | Jin, R, Gouaux, E. | Deposit date: | 2002-10-03 | Release date: | 2003-06-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal. Biochemistry, 42, 2003
|
|
1MXW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1mxw by Molmil](/molmil-images/mine/1mxw) | crystal titration experiments (AMPA co-crystals soaked in 1 mM BrW) | Descriptor: | GLUTAMATE RECEPTOR 2, ZINC ION | Authors: | Jin, R, Gouaux, E. | Deposit date: | 2002-10-03 | Release date: | 2003-06-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal. Biochemistry, 42, 2003
|
|