7RN7
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![BU of 7rn7 by Molmil](/molmil-images/mine/7rn7) | Crystal structure of caspase-3 with inhibitor Ac-VD(Aly)VD-CHO | Descriptor: | Ac-VD(Aly)VD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 | Authors: | McCue, W, Finzel, B.C. | Deposit date: | 2021-07-29 | Release date: | 2022-01-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314. Acs Pharmacol Transl Sci, 5, 2022
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7RNB
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![BU of 7rnb by Molmil](/molmil-images/mine/7rnb) | Crystal structure of caspase-3 with inhibitor Ac-VDRVD-CHO | Descriptor: | Ac-VDRVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 | Authors: | McCue, W, Finzel, B.C. | Deposit date: | 2021-07-29 | Release date: | 2022-01-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314. Acs Pharmacol Transl Sci, 5, 2022
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7RN9
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![BU of 7rn9 by Molmil](/molmil-images/mine/7rn9) | Crystal structure of caspase-3 with inhibitor Ac-VDFVD-CHO | Descriptor: | Ac-VDFVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 | Authors: | McCue, W, Finzel, B.C. | Deposit date: | 2021-07-29 | Release date: | 2022-01-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314. Acs Pharmacol Transl Sci, 5, 2022
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7RNF
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![BU of 7rnf by Molmil](/molmil-images/mine/7rnf) | Crystal structure of caspase-3 with inhibitor Ac-VDKVD-CHO | Descriptor: | Ac-VDKVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 | Authors: | McCue, W, Finzel, B.C. | Deposit date: | 2021-07-29 | Release date: | 2022-01-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314. Acs Pharmacol Transl Sci, 5, 2022
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7RNA
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![BU of 7rna by Molmil](/molmil-images/mine/7rna) | |
7RNG
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![BU of 7rng by Molmil](/molmil-images/mine/7rng) | |
7RNC
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![BU of 7rnc by Molmil](/molmil-images/mine/7rnc) | |
4AF8
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![BU of 4af8 by Molmil](/molmil-images/mine/4af8) | The structural basis for metacaspase substrate specificity and activation | Descriptor: | CHLORIDE ION, METACASPASE MCA2, SODIUM ION | Authors: | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | Deposit date: | 2012-01-18 | Release date: | 2012-05-02 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal Structure of a Trypanosoma Brucei Metacaspase. Proc.Natl.Acad.Sci.USA, 109, 2012
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3V4O
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![BU of 3v4o by Molmil](/molmil-images/mine/3v4o) | |
3V6L
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![BU of 3v6l by Molmil](/molmil-images/mine/3v6l) | Crystal Structure of caspase-6 inactivation mutation | Descriptor: | Caspase-6 | Authors: | Cao, Q, Wang, X.J, Liu, D.F, Li, L.F, Su, X.D. | Deposit date: | 2011-12-20 | Release date: | 2012-03-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays J.Biol.Chem., 287, 2012
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3V6M
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![BU of 3v6m by Molmil](/molmil-images/mine/3v6m) | Inhibition of caspase-6 activity by single mutation outside the active site | Descriptor: | Caspase-6 | Authors: | Cao, Q, Wang, X.J, Liu, D.F, Li, L.F, Su, X.D. | Deposit date: | 2011-12-20 | Release date: | 2012-03-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.692 Å) | Cite: | Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays J.Biol.Chem., 287, 2012
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4AFV
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![BU of 4afv by Molmil](/molmil-images/mine/4afv) | THE STRUCTURE OF METACASPASE 2 FROM T. BRUCEI DETERMINED IN THE PRESENCE OF CALCIUM CHLORIDE | Descriptor: | METACASPASE MCA2 | Authors: | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | Deposit date: | 2012-01-23 | Release date: | 2012-05-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal Structure of a Trypanosoma Brucei Metacaspase. Proc.Natl.Acad.Sci.USA, 109, 2012
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4AFP
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![BU of 4afp by Molmil](/molmil-images/mine/4afp) | The structure of metacaspase 2 from T. brucei determined in the presence of Samarium | Descriptor: | METACASPASE MCA2, SAMARIUM (III) ION | Authors: | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | Deposit date: | 2012-01-23 | Release date: | 2012-05-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of a Trypanosoma Brucei Metacaspase. Proc.Natl.Acad.Sci.USA, 109, 2012
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4AFR
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![BU of 4afr by Molmil](/molmil-images/mine/4afr) | THE STRUCTURE OF METACASPASE 2 (C213A MUTANT) FROM T. BRUCEI | Descriptor: | METACASPASE | Authors: | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | Deposit date: | 2012-01-23 | Release date: | 2012-05-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal Structure of a Trypanosoma Brucei Metacaspase. Proc.Natl.Acad.Sci.USA, 109, 2012
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3R7N
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![BU of 3r7n by Molmil](/molmil-images/mine/3r7n) | Caspase-2 bound with two copies of Ac-DVAD-CHO | Descriptor: | Caspase-2 subunit p12, Caspase-2 subunit p18, Peptide Inhibitor (ACE)DVAD-CHO | Authors: | Tang, Y, Wells, J, Arkin, M. | Deposit date: | 2011-03-22 | Release date: | 2011-07-27 | Last modified: | 2012-12-12 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J.Biol.Chem., 286, 2011
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4DCP
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![BU of 4dcp by Molmil](/molmil-images/mine/4dcp) | Crystal Structure of caspase 3, L168F mutant | Descriptor: | Caspase Inhibitor AC-DEVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 | Authors: | Chung, S.J, Kang, H.J, Kim, S.J. | Deposit date: | 2012-01-18 | Release date: | 2012-12-12 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7 Biosci.Rep., 32, 2012
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4EHA
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![BU of 4eha by Molmil](/molmil-images/mine/4eha) | Allosteric Modulation of Caspase-3 through Mutagenesis | Descriptor: | ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 | Authors: | Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. | Deposit date: | 2012-04-02 | Release date: | 2012-06-06 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.696 Å) | Cite: | Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
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3R5K
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3RJM
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![BU of 3rjm by Molmil](/molmil-images/mine/3rjm) | CASPASE2 IN COMPLEX WITH CHDI LIGAND 33c | Descriptor: | Caspase-2, Peptide inhibitor (ACE)VDV(3PX)D-CHO | Authors: | Abendroth, J, Lorimer, D, Stewart, L, Maillard, M, Kiselyov, A.S. | Deposit date: | 2011-04-15 | Release date: | 2011-09-21 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Exploiting differences in caspase-2 and -3 S(2) subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors. Bioorg.Med.Chem., 19, 2011
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4EHH
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![BU of 4ehh by Molmil](/molmil-images/mine/4ehh) | Allosteric Modulation of Caspase-3 through Mutagenesis | Descriptor: | ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 | Authors: | Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. | Deposit date: | 2012-04-02 | Release date: | 2012-06-06 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
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3S70
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![BU of 3s70 by Molmil](/molmil-images/mine/3s70) | Crystal structure of active caspase-6 bound with Ac-VEID-CHO solved by As-SAD | Descriptor: | ACETATE ION, CACODYLATE ION, Caspase-6, ... | Authors: | Su, X.-D, Liu, X, Wang, X.-J. | Deposit date: | 2011-05-26 | Release date: | 2012-04-11 | Last modified: | 2012-12-12 | Method: | X-RAY DIFFRACTION (1.625 Å) | Cite: | Get phases from arsenic anomalous scattering: de novo SAD phasing of two protein structures crystallized in cacodylate buffer Plos One, 6, 2011
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3S8E
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![BU of 3s8e by Molmil](/molmil-images/mine/3s8e) | |
4DCJ
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![BU of 4dcj by Molmil](/molmil-images/mine/4dcj) | Crystal structure of caspase 3, L168D mutant | Descriptor: | Caspase Inhibitor AC-DEVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 | Authors: | Chung, S.J, Kang, H.J, Kim, S.J. | Deposit date: | 2012-01-17 | Release date: | 2012-12-12 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7 Biosci.Rep., 32, 2012
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3R6G
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![BU of 3r6g by Molmil](/molmil-images/mine/3r6g) | |
3R7S
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![BU of 3r7s by Molmil](/molmil-images/mine/3r7s) | Crystal Structure of Apo Caspase2 | Descriptor: | Caspase-2 subunit p12, Caspase-2 subunit p18 | Authors: | Tang, Y, Wells, J, Arkin, M. | Deposit date: | 2011-03-22 | Release date: | 2011-07-27 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (2.252 Å) | Cite: | Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J.Biol.Chem., 286, 2011
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