7RN7

Crystal structure of caspase-3 with inhibitor Ac-VD(Aly)VD-CHO

Summary for 7RN7

• Entry DOI: 10.2210/pdb7rn7/pdb
• Descriptor: Caspase-3 subunit p17, Caspase-3 subunit p12, Ac-VD(Aly)VD-CHO, ... (4 entities in total)
• Functional Keywords: hydrolase/hydrolase inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 55935.88

Authors

McCue, W.,Finzel, B.C. (deposition date: 2021-07-29, release date: 2022-01-05, Last modification date: 2023-11-15)

• Primary citation: Bresinsky, M.,Strasser, J.M.,Vallaster, B.,Liu, P.,McCue, W.M.,Fuller, J.,Hubmann, A.,Singh, G.,Nelson, K.M.,Cuellar, M.E.,Wilmot, C.M.,Finzel, B.C.,Ashe, K.H.,Walters, M.A.,Pockes, S.; Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314.; Acs Pharmacol Transl Sci, 5:20-40, 2022; PubMed: 35059567; DOI: 10.1021/acsptsci.1c00251

Experimental method

X-RAY DIFFRACTION (2.4 Å)