7RNF

Crystal structure of caspase-3 with inhibitor Ac-VDKVD-CHO

Summary for 7RNF

Entry DOI	10.2210/pdb7rnf/pdb
Descriptor	Caspase-3 subunit p17, Caspase-3 subunit p12, Ac-VDKVD-CHO, ... (4 entities in total)
Functional Keywords	hydrolase/hydrolase inhibitor, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	55821.82
Authors	McCue, W.,Finzel, B.C. (deposition date: 2021-07-29, release date: 2022-01-05, Last modification date: 2024-02-07)
Primary citation	Bresinsky, M.,Strasser, J.M.,Vallaster, B.,Liu, P.,McCue, W.M.,Fuller, J.,Hubmann, A.,Singh, G.,Nelson, K.M.,Cuellar, M.E.,Wilmot, C.M.,Finzel, B.C.,Ashe, K.H.,Walters, M.A.,Pockes, S. Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314. Acs Pharmacol Transl Sci, 5:20-40, 2022 Cited by PubMed: 35059567 DOI: 10.1021/acsptsci.1c00251 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation