8WUU
 
 | | SpCas9-pegRNA-target DNA complex (pre-initiation) | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, DNA (34-MER), DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), ... | | Authors: | Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O. | | Deposit date: | 2023-10-21 | | Release date: | 2024-06-05 | | Last modified: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis for pegRNA-guided reverse transcription by a prime editor.
Nature, 631, 2024
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8WUS
 | | SpCas9-MMLV RT-pegRNA-target DNA complex (termination) | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, DNA (40-MER), DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), ... | | Authors: | Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O. | | Deposit date: | 2023-10-21 | | Release date: | 2024-06-05 | | Last modified: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis for pegRNA-guided reverse transcription by a prime editor.
Nature, 631, 2024
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7VK9
 | | Crystal structure of xCas9 P411T | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1 | | Authors: | Bao, R, Liu, H.Y, Luo, Y.Z, Song, Y.J. | | Deposit date: | 2021-09-29 | | Release date: | 2022-04-06 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural and Dynamics Studies of the Spcas9 Variant Provide Insights into the Regulatory Role of the REC1 Domain
Acs Catalysis, 12, 2022
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8U3Y
 | | SpG Cas9 with NGG PAM DNA target | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(P*CP*GP*TP*TP*TP*GP*TP*AP*CP*TP*CP*CP*AP*GP*CP*G)-3'), DNA (5'-D(P*TP*CP*TP*CP*AP*TP*CP*TP*TP*TP*AP*TP*GP*CP*GP*TP*C)-3'), ... | | Authors: | Bravo, J.P.K, Hibshman, G.N, Taylor, D.W. | | Deposit date: | 2023-09-08 | | Release date: | 2024-05-01 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
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1C3F
 | | Endo-Beta-N-Acetylglucosaminidase H, D130N Mutant | | Descriptor: | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE H | | Authors: | Rao, V, Cui, T, Guan, C, Van Roey, P. | | Deposit date: | 1999-07-27 | | Release date: | 1999-11-26 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Mutations of endo-beta-N-acetylglucosaminidase H active site residues Asp130 and Glu132: activities and conformations.
Protein Sci., 8, 1999
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8YGJ
 | | SpCas9-MMLV RT-pegRNA-target DNA complex (elongation 28-nt) | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(P*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), DNA (51-MER), ... | | Authors: | Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O. | | Deposit date: | 2024-02-26 | | Release date: | 2024-06-05 | | Last modified: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis for pegRNA-guided reverse transcription by a prime editor.
Nature, 631, 2024
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8YJ7
 | | Characerization of a novel format scFvXVHH single-chain Biparatopic antibody against a metal binding protein, MtsA | | Descriptor: | Iron ABC transporter substrate-binding lipoprotein MtsA, ZINC ION, scFv13 | | Authors: | Ito, S, Nagatoishi, S, Nakakido, M, Tsumoto, K. | | Deposit date: | 2024-03-01 | | Release date: | 2024-06-19 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Characterization of a novel format scFv×VHH single-chain biparatopic antibody against metal binding protein MtsA.
Protein Sci., 33, 2024
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8YJ8
 | | Characerization of a novel format scFvXVHH single-chain Biparatopic antibody against a metal binding protein, MtsA | | Descriptor: | Iron ABC transporter substrate-binding lipoprotein MtsA, VHH43, ZINC ION | | Authors: | Ito, S, Nagatoishi, S, Nakakido, M, Tsumoto, K. | | Deposit date: | 2024-03-01 | | Release date: | 2024-06-19 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Characterization of a novel format scFv×VHH single-chain biparatopic antibody against metal binding protein MtsA.
Protein Sci., 33, 2024
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8YJ5
 | | Characerization of a novel format scFvXVHH single-chain Biparatopic antibody against a metal binding protein, MtsA | | Descriptor: | Iron ABC transporter substrate-binding lipoprotein MtsA, VHH43 | | Authors: | Ito, S, Nagatoishi, S, Nakakido, M, Tsumoto, K. | | Deposit date: | 2024-03-01 | | Release date: | 2024-06-19 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.66 Å) | | Cite: | Characterization of a novel format scFv×VHH single-chain biparatopic antibody against metal binding protein MtsA.
Protein Sci., 33, 2024
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8YJ6
 | | Characerization of a novel format scFvXVHH single-chain Biparatopic antibody against a metal binding protein, MtsA | | Descriptor: | Iron ABC transporter substrate-binding lipoprotein MtsA, ZINC ION | | Authors: | Ito, S, Nagatoishi, S, Nakakido, M, Tsumoto, K. | | Deposit date: | 2024-03-01 | | Release date: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.37 Å) | | Cite: | Characterization of a novel format scFv×VHH single-chain biparatopic antibody against metal binding protein MtsA.
Protein Sci., 33, 2024
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7Z4E
 | | SpCas9 bound to 8-nucleotide complementary DNA substrate | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 8 nucleotide complementary DNA substrate, Target strand of 8 nucleotide complementary DNA substrate, ... | | Authors: | Pacesa, M, Jinek, M. | | Deposit date: | 2022-03-03 | | Release date: | 2022-08-31 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (4.14 Å) | | Cite: | R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
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7Z4I
 | | SpCas9 bound to 16-nucleotide complementary DNA substrate | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 16-nucleotide complementary DNA substrate, POTASSIUM ION, ... | | Authors: | Pacesa, M, Jinek, M. | | Deposit date: | 2022-03-03 | | Release date: | 2022-08-31 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
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7Z4H
 | | SpCas9 bound to 14-nucleotide complementary DNA substrate | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 14-nucleotide complementary DNA substrate, Target strand of 14-nucleotide complementary DNA substrate, ... | | Authors: | Pacesa, M, Jinek, M. | | Deposit date: | 2022-03-03 | | Release date: | 2022-08-31 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.49 Å) | | Cite: | R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
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7Z4C
 | | SpCas9 bound to 6 nucleotide complementary DNA substrate | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 6 nucleotide complementary DNA substrate, Target strand of 6 nucleotide complementary DNA substrate, ... | | Authors: | Pacesa, M, Jinek, M. | | Deposit date: | 2022-03-03 | | Release date: | 2022-08-31 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.87 Å) | | Cite: | R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
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7Z4G
 | | SpCas9 bound to 12-nucleotide complementary DNA substrate | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 12-nucleotide complementary DNA substrate, Target strand of 12-nucleotide complementary DNA substrate, ... | | Authors: | Pacesa, M, Jinek, M. | | Deposit date: | 2022-03-03 | | Release date: | 2022-08-31 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.64 Å) | | Cite: | R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
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7Z4K
 | | SpCas9 bound to 10-nucleotide complementary DNA substrate | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 10-nucleotide complementary DNA substrate, Target strand of 10-nucleotide complementary DNA substrate, ... | | Authors: | Pacesa, M, Jinek, M. | | Deposit date: | 2022-03-04 | | Release date: | 2022-08-31 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.81 Å) | | Cite: | R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
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7Z4J
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7Z4L
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7Z4D
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1C90
 | | Endo-Beta-N-Acetylglucosaminidase H, E132Q Mutant | | Descriptor: | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE H | | Authors: | Rao, V, Tao, C, Guan, C, Van Roey, P. | | Deposit date: | 1999-07-30 | | Release date: | 1999-11-26 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Mutations of endo-beta-N-acetylglucosaminidase H active site residues Assp130 and Glu132: activities and conformations.
Protein Sci., 8, 1999
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1C92
 | | Endo-Beta-N-Acetylglucosaminidase H, E132A Mutant | | Descriptor: | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE H | | Authors: | Rao, V, Cui, T, Guan, C, Van Roey, P. | | Deposit date: | 1999-07-30 | | Release date: | 1999-11-26 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Mutations of endo-beta-N-acetylglucosaminidase H active site residues Asp130 and Glu132: activities and conformations.
Protein Sci., 8, 1999
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1C8X
 | | Endo-Beta-N-Acetylglucosaminidase H, D130E Mutant | | Descriptor: | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE H, PHOSPHATE ION | | Authors: | Rao, V, Tao, C, Guan, C, Van Roey, P. | | Deposit date: | 1999-07-30 | | Release date: | 1999-11-26 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Mutations of endo-beta-N-acetylglucosaminidase H active site residues Asp130 and Glu132: activities and conformations.
Protein Sci., 8, 1999
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1C91
 | | Endo-Beta-N-Acetylglucosaminidase H, E132D | | Descriptor: | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE H | | Authors: | Rao, V, Cui, T, Guan, C, Van Roey, P. | | Deposit date: | 1999-07-30 | | Release date: | 1999-11-26 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Mutations of endo-beta-N-acetylglucosaminidase H active site residues Asp130 and Glu132: activities and conformations.
Protein Sci., 8, 1999
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1C8Y
 | | Endo-Beta-N-Acetylglucosaminidase H, D130A Mutant | | Descriptor: | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE H, ZINC ION | | Authors: | Rao, V, Cui, T, Guan, C, Van Roey, P. | | Deposit date: | 1999-07-30 | | Release date: | 1999-11-26 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Mutations of endo-beta-N-acetylglucosaminidase H active site residues Asp130 and Glu132: activities and conformations.
Protein Sci., 8, 1999
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1C82
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