6WYL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wyl by Molmil](/molmil-images/mine/6wyl) | Cryo-EM structure of GltPh L152C-G351C mutant in the intermediate outward-facing state. | Descriptor: | ASPARTIC ACID, Glutamate transporter homolog | Authors: | Font, J, Chen, I, Sobti, M, Stewart, A.G, Ryan, R.M. | Deposit date: | 2020-05-13 | Release date: | 2021-02-17 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Glutamate transporters have a chloride channel with two hydrophobic gates. Nature, 591, 2021
|
|
6WYK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wyk by Molmil](/molmil-images/mine/6wyk) | Cryo-EM structure of the GltPh L152C-G321C mutant in the intermediate chloride conducting state. | Descriptor: | ASPARTIC ACID, Glutamate transporter homolog | Authors: | Font, J, Chen, I, Sobti, M, Stewart, A.G, Ryan, R.M. | Deposit date: | 2020-05-13 | Release date: | 2021-02-17 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Glutamate transporters have a chloride channel with two hydrophobic gates. Nature, 591, 2021
|
|
6X01
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6x01 by Molmil](/molmil-images/mine/6x01) | |
3CL1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3cl1 by Molmil](/molmil-images/mine/3cl1) | M. loti cyclic-nucleotide binding domain, cyclic-GMP bound | Descriptor: | CHLORIDE ION, CYCLIC GUANOSINE MONOPHOSPHATE, Mll3241 protein, ... | Authors: | Clayton, G.M, Alteiri, S.L, Thomas, L.R, Morais-Cabral, J.H. | Deposit date: | 2008-03-18 | Release date: | 2008-08-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and Energetic Analysis of Activation by a Cyclic Nucleotide Binding Domain. J.Mol.Biol., 381, 2008
|
|
7QEQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qeq by Molmil](/molmil-images/mine/7qeq) | human Connexin 26 dodecamer at 90mmHg PCO2, pH7.4 | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | Authors: | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | Deposit date: | 2021-12-03 | Release date: | 2022-03-30 | Last modified: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (1.9 Å) | Cite: | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
|
|
7QEW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qew by Molmil](/molmil-images/mine/7qew) | human Connexin 26 class 2 hexamer at 90mmHg PCO2, pH7.4 | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | Authors: | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | Deposit date: | 2021-12-03 | Release date: | 2022-03-30 | Last modified: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
|
|
7QER
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qer by Molmil](/molmil-images/mine/7qer) | human Connexin 26 dodecamer at 55mm Hg PCO2, pH7.4 | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | Authors: | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | Deposit date: | 2021-12-03 | Release date: | 2022-03-30 | Last modified: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
|
|
7QET
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qet by Molmil](/molmil-images/mine/7qet) | human Connexin 26 dodecamer at 20mmHg PCO2, pH7.4 | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | Authors: | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | Deposit date: | 2021-12-03 | Release date: | 2022-03-30 | Last modified: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
|
|
6X23
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6x23 by Molmil](/molmil-images/mine/6x23) | |
4NH2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4nh2 by Molmil](/molmil-images/mine/4nh2) | Crystal structure of AmtB from E. coli bound to phosphatidylglycerol | Descriptor: | (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Ammonia channel | Authors: | Laganowsky, A, Reading, E, Allison, T.M, Robinson, C.V. | Deposit date: | 2013-11-04 | Release date: | 2014-06-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Membrane proteins bind lipids selectively to modulate their structure and function. Nature, 510, 2014
|
|
7E8G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7e8g by Molmil](/molmil-images/mine/7e8g) | |
7E89
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7e89 by Molmil](/molmil-images/mine/7e89) | |
7QEU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qeu by Molmil](/molmil-images/mine/7qeu) | human Connexin 26 at 55mmHg PCO2, pH7.4: two masked subunits, class B | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | Authors: | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | Deposit date: | 2021-12-03 | Release date: | 2022-06-15 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
|
|
7QEV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qev by Molmil](/molmil-images/mine/7qev) | human Connexin 26 at 55mm Hg PCO2, pH7.4:two masked subunits, class D | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | Authors: | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | Deposit date: | 2021-12-03 | Release date: | 2022-06-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
|
|
7QES
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qes by Molmil](/molmil-images/mine/7qes) | human Connexin 26 at 55mm Hg PCO2, pH7.4: two masked subunits, class A | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | Authors: | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | Deposit date: | 2021-12-03 | Release date: | 2022-06-15 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
|
|
7QEO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qeo by Molmil](/molmil-images/mine/7qeo) | human Connexin 26 at 55mm Hg PCO2, pH7.4: two masked subunits, class C | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Gap junction beta-2 protein, PHOSPHATIDYLETHANOLAMINE | Authors: | Brotherton, D.H, Cameron, A.D, Savva, C.G, Ragan, T.J. | Deposit date: | 2021-12-03 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Conformational changes and CO 2 -induced channel gating in connexin26. Structure, 30, 2022
|
|
6R88
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6r88 by Molmil](/molmil-images/mine/6r88) | Structure of Arabidopsis thaliana GLR3.3 ligand-binding domain in complex with glycine | Descriptor: | CHLORIDE ION, GLYCEROL, GLYCINE, ... | Authors: | Alfieri, A, Pederzoli, R, Costa, A. | Deposit date: | 2019-04-01 | Release date: | 2020-01-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The structural bases for agonist diversity in anArabidopsis thalianaglutamate receptor-like channel. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
7KJR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7kjr by Molmil](/molmil-images/mine/7kjr) | Cryo-EM structure of SARS-CoV-2 ORF3a | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Apolipoprotein A-I, ORF3a protein | Authors: | Kern, D.M, Hoel, C.M, Kotecha, A, Brohawn, S.G. | Deposit date: | 2020-10-26 | Release date: | 2020-11-18 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.08 Å) | Cite: | Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs. Nat.Struct.Mol.Biol., 28, 2021
|
|
5VSN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5vsn by Molmil](/molmil-images/mine/5vsn) | |
2OSH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2osh by Molmil](/molmil-images/mine/2osh) | |
7RTF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rtf by Molmil](/molmil-images/mine/7rtf) | SthK R120A Closed State | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | Authors: | Gao, X, Nimigean, C. | Deposit date: | 2021-08-13 | Release date: | 2022-11-23 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
|
|
7RSH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rsh by Molmil](/molmil-images/mine/7rsh) | SthK Y26F Closed State | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | Authors: | Gao, X, Nimigean, C. | Deposit date: | 2021-08-11 | Release date: | 2022-11-23 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
|
|
7RTJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rtj by Molmil](/molmil-images/mine/7rtj) | SthK Y26F Activated State | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | Authors: | Gao, X, Nimigean, C. | Deposit date: | 2021-08-13 | Release date: | 2022-11-23 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
|
|
5DO6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5do6 by Molmil](/molmil-images/mine/5do6) | Crystal structure of Dendroaspis polylepis venom mambalgin-1 T23A mutant | Descriptor: | 1,2-ETHANEDIOL, IODIDE ION, Mambalgin-1, ... | Authors: | Stura, E.A, Tepshi, L, Kessler, P, Gilles, M, Servent, D. | Deposit date: | 2015-09-10 | Release date: | 2015-12-30 | Last modified: | 2017-01-25 | Method: | X-RAY DIFFRACTION (1.697 Å) | Cite: | Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition. J.Biol.Chem., 291, 2016
|
|
7RYS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rys by Molmil](/molmil-images/mine/7rys) | SthK R120A Open State 2 | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | Authors: | Gao, X, Nimigean, C, Schmidpeter, P. | Deposit date: | 2021-08-26 | Release date: | 2022-11-23 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
|
|