PDB: 326 resultsInfo pagesStatus searchChemie searchBIRD

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4JK2	X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with guanosine pentaphosphate (pppGpp) Descriptor: Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ... Authors: Murakami, K.S. Deposit date: 2013-03-09 Release date: 2013-04-17 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (4.201 Å) Cite: Differential regulation by ppGpp versus pppGpp in Escherichia coli. Nucleic Acids Res., 41, 2013
6IN7	Crystal structure of AlgU in complex with MucA(cyto) Descriptor: NICOTINAMIDE, RNA polymerase sigma-H factor, Sigma factor AlgU negative regulatory protein Authors: Li, S, Zhang, Q, Bartlam, M. Deposit date: 2018-10-24 Release date: 2019-07-24 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Structural basis for the recognition of MucA by MucB and AlgU in Pseudomonas aeruginosa. Febs J., 286, 2019
6JBQ	CryoEM structure of Escherichia coli sigmaE transcription initiation complex containing 5nt of RNA Descriptor: DNA (48-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Fang, C.L, Zhang, Y. Deposit date: 2019-01-26 Release date: 2019-05-29 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (4.02 Å) Cite: Structures and mechanism of transcription initiation by bacterial ECF factors. Nucleic Acids Res., 47, 2019
6JNX	Cryo-EM structure of a Q-engaged arrested complex Descriptor: Antiterminator Q protein, DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Feng, Y, Shi, J. Deposit date: 2019-03-18 Release date: 2019-06-12 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (4.08 Å) Cite: Structural basis of Q-dependent transcription antitermination. Nat Commun, 10, 2019
6JCX	Mycobacterium tuberculosis transcription initiation complex with ECF sigma factor sigma H and 6nt RNA Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2019-01-30 Release date: 2019-05-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.903 Å) Cite: Structures and mechanism of transcription initiation by bacterial ECF factors. Nucleic Acids Res., 47, 2019
6JCY	Mycobacterium tuberculosis RNA polymerase transcription initiation open complex with a chimeric ECF sigma factor sigH/E Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2019-01-30 Release date: 2019-05-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.106 Å) Cite: Structures and mechanism of transcription initiation by bacterial ECF factors. Nucleic Acids Res., 47, 2019
6K4Y	CryoEM structure of sigma appropriation complex Descriptor: 10 kDa anti-sigma factor, DNA (60-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Shi, J, Wen, A, Feng, Y. Deposit date: 2019-05-27 Release date: 2019-08-07 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.79 Å) Cite: Structural basis of sigma appropriation. Nucleic Acids Res., 47, 2019
6KJ6	cryo-EM structure of Escherichia coli Crl transcription activation complex Descriptor: DNA (51-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Xu, J, Zhang, Y. Deposit date: 2019-07-21 Release date: 2020-01-01 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor. Elife, 8, 2019
7MKJ	Cryo-EM structure of Escherichia coli RNA polymerase bound to T7A1 promoter DNA Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Saecker, R.M, Darst, S.A, Chen, J. Deposit date: 2021-04-23 Release date: 2021-09-29 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKD	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 1) Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Saecker, R.M, Darst, S.A, Chen, J. Deposit date: 2021-04-23 Release date: 2021-09-29 Last modified: 2021-10-13 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKE	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 2) Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Saecker, R.M, Darst, S.A, Chen, J. Deposit date: 2021-04-23 Release date: 2021-09-29 Last modified: 2021-10-13 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7MKI	Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR (-5G to C) promoter DNA Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Saecker, R.M, Darst, S.A, Chen, J. Deposit date: 2021-04-23 Release date: 2021-09-29 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proc.Natl.Acad.Sci.USA, 118, 2021
7N4E	Escherichia coli sigma 70-dependent paused transcription elongation complex Descriptor: 5'-R(*UP*UP*CP*GP*GP*AP*GP*AP*GP*GP*UP*A)-3', DNA (61-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Molodtsov, V, Su, M, Ebright, R.H. Deposit date: 2021-06-04 Release date: 2022-06-15 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural and mechanistic basis of sigma-dependent transcriptional pausing. Proc.Natl.Acad.Sci.USA, 119, 2022
7MLB	Crystal structure of Thermus thermophilus transcription initiation complex with 5nt RNA Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*AP*GP*GP*GP*AP*TP*GP*CP*AP*G)-3'), DNA (5'-D(P*CP*TP*GP*CP*AP*TP*CP*CP*CP*TP*GP*AP*GP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, Y, Ebright, R.H. Deposit date: 2021-04-28 Release date: 2022-02-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
7MLI	Crystal structure of Thermus thermophilus reiterative transcription complex with 5nt oligo-C RNA Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*CP*TP*AP*CP*GP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*CP*GP*TP*AP*GP*GP*GP*CP*GP*GP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, Y, Ebright, R.H. Deposit date: 2021-04-28 Release date: 2022-02-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
7MLJ	Crystal structure of Thermus thermophilus reiterative transcription complex with 4nt oligo-G RNA Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*GP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*CP*GP*TP*GP*CP*CP*CP*TP*GP*AP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, Y, Ebright, R.H. Deposit date: 2021-04-28 Release date: 2022-02-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.75 Å) Cite: Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
6DVB	Crystal structure of Mycobacterium tuberculosis transcription initiation complex(ECF sigma factor L) containing 5nt RNA with 5nt spacer Descriptor: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(P*CP*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Lin, W, Das, K, Feng, Y, Ebright, R.H. Deposit date: 2018-06-23 Release date: 2019-02-20 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Structural basis of ECF-sigma-factor-dependent transcription initiation. Nat Commun, 10, 2019
6DV9	Crystal structure of Mycobacterium tuberculosis transcription initiation complex(ECF sigma factor L) containing 5nt RNA with 4nt spacer Descriptor: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(P*CP*GP*TP*GP*TP*CP*AP*GP*AP*GP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Lin, W, Das, K, Feng, Y, Ebright, R.H. Deposit date: 2018-06-23 Release date: 2019-02-20 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Structural basis of ECF-sigma-factor-dependent transcription initiation. Nat Commun, 10, 2019
6DVE	Crystal structure of Mycobacterium tuberculosis transcription initiation complex(ECF selenomethionine-labelled sigma factor L) with 6 nt spacer Descriptor: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*T)-3'), DNA (5'-D(P*CP*GP*TP*GP*TP*GP*AP*GP*TP*AP*AP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Lin, W, Das, K, Feng, Y, Ebright, R.H. Deposit date: 2018-06-23 Release date: 2019-02-20 Last modified: 2019-02-27 Method: X-RAY DIFFRACTION (3.812 Å) Cite: Structural basis of ECF-sigma-factor-dependent transcription initiation. Nat Commun, 10, 2019
6EEC	Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD and AP3 promoter captured by Corallopyronin Descriptor: DNA (63-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. Deposit date: 2018-08-13 Release date: 2018-11-21 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.55 Å) Cite: Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
8HKC	Cryo-EM structure of E. coli RNAP sigma32 complex Descriptor: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Wu, S, Ma, L.X. Deposit date: 2022-11-25 Release date: 2023-05-31 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (2.49 Å) Cite: Structural Insight into the Mechanism of sigma 32-Mediated Transcription Initiation of Bacterial RNA Polymerase. Biomolecules, 13, 2023
6EDT	Mycobacterium tuberculosis RNAP open promoter complex with RbpA/CarD and AP3 promoter Descriptor: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. Deposit date: 2018-08-10 Release date: 2018-11-21 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY Cite: Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
6EE8	Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD and AP3 promoter Descriptor: DNA (60-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. Deposit date: 2018-08-13 Release date: 2018-11-21 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.92 Å) Cite: Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
8H3V	Cryo-EM structure of the full transcription activation complex NtcA-NtcB-TAC Descriptor: DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. Deposit date: 2022-10-09 Release date: 2023-10-04 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024
8H40	Cryo-EM structure of the transcription activation complex NtcA-TAC Descriptor: DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. Deposit date: 2022-10-09 Release date: 2023-10-04 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024

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