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7ULW
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BU of 7ulw by Molmil
CryoEM structure of human LACTB filament
Descriptor: Serine beta-lactamase-like protein LACTB, mitochondrial
Authors:Bennett, J.A, Steward, L.R, Aydin, H.
Deposit date:2022-04-05
Release date:2022-12-07
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding.
Plos Biol., 20, 2022
7V1Z
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BU of 7v1z by Molmil
human Serine beta-lactamase-like protein LACTB
Descriptor: Serine beta-lactamase-like protein LACTB, mitochondrial
Authors:Zhang, M.H, Yang, M.J.
Deposit date:2021-08-07
Release date:2022-02-16
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB.
Structure, 30, 2022
7V21
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BU of 7v21 by Molmil
human Serine beta-lactamase-like protein LACTB truncation variant
Descriptor: Serine beta-lactamase-like protein LACTB, mitochondrial
Authors:Zhang, M.H, Yang, M.J.
Deposit date:2021-08-07
Release date:2022-02-16
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB.
Structure, 30, 2022
7V1Y
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BU of 7v1y by Molmil
Serine beta-lactamase-like protein LACTB in complex with inhibitor
Descriptor: ALA-ALA-B3S, Serine beta-lactamase-like protein LACTB, mitochondrial
Authors:Zhang, M.H, Yang, M.J.
Deposit date:2021-08-07
Release date:2022-02-16
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB.
Structure, 30, 2022
7UL6
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BU of 7ul6 by Molmil
CryoEM structure of full-length dimeric ClbP
Descriptor: Beta-lactamase
Authors:Velilla, J.A, Walsh Jr, R.M, Gaudet, R.
Deposit date:2022-04-04
Release date:2022-09-28
Last modified:2023-02-15
Method:ELECTRON MICROSCOPY (3.73 Å)
Cite:Structural basis of colibactin activation by the ClbP peptidase.
Nat.Chem.Biol., 19, 2023
6DPZ
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BU of 6dpz by Molmil
X-ray crystal structure of AmpC beta-lactamase with inhibitor
Descriptor: (1R,2S)-2-{[(pyrrolidin-1-yl)sulfonyl]amino}cyclooctane-1-carboxylic acid, Beta-lactamase
Authors:Singh, I.
Deposit date:2018-06-09
Release date:2018-07-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Ultra-large library docking for discovering new chemotypes.
Nature, 566, 2019
6DPT
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BU of 6dpt by Molmil
X-ray crystal structure of AmpC beta-lactamase with nanomolar inhibitor
Descriptor: 3-chloro-2-hydroxy-N-{2-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]phenyl}benzene-1-sulfonamide, Beta-lactamase
Authors:Singh, I.
Deposit date:2018-06-09
Release date:2018-07-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Ultra-large library docking for discovering new chemotypes.
Nature, 566, 2019
3PTE
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BU of 3pte by Molmil
THE REFINED CRYSTALLOGRAPHIC STRUCTURE OF A DD-PEPTIDASE PENICILLIN-TARGET ENZYME AT 1.6 A RESOLUTION
Descriptor: D-ALANYL-D-ALANINE CARBOXYPEPTIDASE TRANSPEPTIDASE
Authors:Kelly, J.A, Kuzin, A.P.
Deposit date:1994-08-05
Release date:1995-08-15
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The refined crystallographic structure of a DD-peptidase penicillin-target enzyme at 1.6 A resolution.
J.Mol.Biol., 254, 1995
6DPY
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BU of 6dpy by Molmil
X-ray crystal structure of AmpC beta-lactamase with inhibitor
Descriptor: 4-{[(4R)-6-fluoro-3,4-dihydro-2H-1-benzopyran-4-yl]sulfamoyl}-2,5-dimethylfuran-3-carboxylic acid, Beta-lactamase
Authors:Singh, I.
Deposit date:2018-06-09
Release date:2018-07-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Ultra-large library docking for discovering new chemotypes.
Nature, 566, 2019
3O86
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BU of 3o86 by Molmil
Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor
Descriptor: Beta-lactamase, PHOSPHATE ION, {[(benzylsulfonyl)amino]methyl}boronic acid
Authors:Eidam, O, Romagnoli, C, Karpiak, J, Shoichet, B.K.
Deposit date:2010-08-02
Release date:2010-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Design, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as beta-Lactamase Inhibitors
J.Med.Chem., 53, 2010
6DPX
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BU of 6dpx by Molmil
X-ray crystal structure of AmpC beta-lactamase with inhibitor
Descriptor: (3-{[(3-chloro-2-hydroxyphenyl)sulfonyl]amino}phenyl)acetic acid, Beta-lactamase
Authors:Singh, I.
Deposit date:2018-06-09
Release date:2018-07-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ultra-large library docking for discovering new chemotypes.
Nature, 566, 2019
3OZH
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BU of 3ozh by Molmil
Crystal Structure of Beta-Lactamase/D-alanine Carboxypeptidase from Yersinia pestis
Descriptor: beta-lactamase/D-alanine carboxypeptidase
Authors:Kim, Y, Zhou, M, Gu, M, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2010-09-24
Release date:2010-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.907 Å)
Cite:Crystal Structure of Beta-Lactamase/D-alanine Carboxypeptidase from Yersinia pestis
To be Published
3O87
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BU of 3o87 by Molmil
Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor
Descriptor: 4-({[(dihydroxyboranyl)methyl]sulfamoyl}methyl)benzoic acid, Beta-lactamase, PHOSPHATE ION
Authors:Eidam, O, Romagnoli, C, Karpiak, J, Shoichet, B.K.
Deposit date:2010-08-02
Release date:2010-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Design, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as beta-Lactamase Inhibitors
J.Med.Chem., 53, 2010
3RJU
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BU of 3rju by Molmil
Crystal Structure of Beta-lactamase/D-alanine Carboxypeptidase from Yersinia pestis complexed with citrate
Descriptor: Beta-lactamase/D-alanine Carboxypeptidase, CITRIC ACID, GLYCEROL
Authors:Kim, Y, Zhou, M, Gu, M, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2011-04-15
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Beta-lactamase/D-alanine Carboxypeptidase from Yersinia pestis complexed with citrate
To be Published
3O88
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BU of 3o88 by Molmil
Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor
Descriptor: 3-[(2R)-2-[(benzylsulfonyl)amino]-2-(dihydroxyboranyl)ethyl]benzoic acid, Beta-lactamase, PHOSPHATE ION
Authors:Eidam, O, Romagnoli, C, Karpiak, J, Shoichet, B.K.
Deposit date:2010-08-02
Release date:2010-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Design, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as beta-Lactamase Inhibitors
J.Med.Chem., 53, 2010
3S22
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BU of 3s22 by Molmil
AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA) in complex with an inhibitor
Descriptor: Beta-lactamase, CHLORIDE ION, [(2S,3R)-2-formyl-1-{[4-(methylamino)butyl]carbamoyl}pyrrolidin-3-yl]sulfamic acid
Authors:Scapin, G, Lu, J, Fitzgerald, P.M.D, Sharma, N.
Deposit date:2011-05-16
Release date:2011-06-29
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Side chain SAR of bicyclic Beta-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712
Bioorg.Med.Chem.Lett., 21, 2011
3SH7
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BU of 3sh7 by Molmil
Crystal structure of fluorophore-labeled beta-lactamase PenP
Descriptor: 1-[6-(dimethylamino)naphthalen-2-yl]ethanone, Beta-lactamase
Authors:Wong, W.-T, Zhao, Y.-X, Leung, Y.-C.
Deposit date:2011-06-16
Release date:2011-07-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Increased structural flexibility at the active site of a fluorophore-conjugated beta-lactamase distinctively impacts its binding toward diverse cephalosporin antibiotics
J.Biol.Chem., 286, 2011
1YQS
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BU of 1yqs by Molmil
Inhibition of the R61 DD-Peptidase by N-benzoyl-beta-sultam
Descriptor: 2-(BENZOYLAMINO)ETHANESULFONIC ACID, D-alanyl-D-alanine carboxypeptidase, GLYCEROL
Authors:Ahmed, N, Cordaro, M, Laws, A.P, Delmarcelle, M, Silvaggi, N.R, Kelly, J.A, Page, M.I.
Deposit date:2005-02-02
Release date:2005-06-28
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Inactivation of Bacterial dd-Peptidase by beta-Sultams.
Biochemistry, 44, 2005
2DCF
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BU of 2dcf by Molmil
Crystal structure of 6-aminohexanoate-dimer hydrolase S112A/G181D/H266N mutant with substrate
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOIC ACID, 6-aminohexanoate-dimer hydrolase, ...
Authors:Ohki, T, Shibata, N, Higuchi, Y, Takeo, M, Negoro, S.
Deposit date:2006-01-06
Release date:2007-01-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Nylon-oligomer degrading enzyme/substrate complex: catalytic mechanism of 6-aminohexanoate-dimer hydrolase
J.Mol.Biol., 370, 2007
1ZC2
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BU of 1zc2 by Molmil
Crystal Structure of plasmid-encoded class C beta-lactamase CMY-2 complexed with citrate molecule
Descriptor: CITRIC ACID, beta-lactamase class C
Authors:Bauvois, C, Jacquamet, L, Fieulaine, S, Frere, J.-M, Galleni, M, Ferrer, J.-L.
Deposit date:2005-04-10
Release date:2006-04-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystallographic structure of plasmid-encoded CMY-2 beta-lactamase revealed citrate molecule in the active site.
To be Published
5CHM
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BU of 5chm by Molmil
CRYSTAL STRUCTURE OF Fox-4 cephamycinase complexed with ceftazidime BATSI (LP06)
Descriptor: ACETATE ION, Beta-lactamase, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE, ...
Authors:Malashkevich, V.N, Toro, R, Lefurgy, S, Almo, S.C.
Deposit date:2015-07-10
Release date:2016-08-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of FOX-4 Cephamycinase in Complex with Transition-State Analog Inhibitors.
Biomolecules, 10, 2020
5CHU
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BU of 5chu by Molmil
CRYSTAL STRUCTURE OF Fox-4 cephamycinase complexed with sulfate
Descriptor: ACETATE ION, Beta-lactamase, SULFATE ION, ...
Authors:Malashkevich, V.N, Toro, R, Lefurgy, S, Almo, S.C.
Deposit date:2015-07-10
Release date:2016-08-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:CRYSTAL STRUCTURE OF Fox-4 cephamycinase complexed with sulfate
To Be Published
5CGS
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BU of 5cgs by Molmil
CRYSTAL STRUCTURE OF Fox-4 cephamycinase
Descriptor: Beta-lactamase, ZINC ION
Authors:Malashkevich, V.N, Toro, R, Lefurgy, S, Almo, S.C.
Deposit date:2015-07-09
Release date:2016-02-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.634 Å)
Cite:FOX-4 cephamycinase: an analysis of structure and function.
Antimicrob.Agents Chemother., 2015
5CGX
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BU of 5cgx by Molmil
CRYSTAL STRUCTURE OF Fox-4 cephamycinase mutant Y150F complexed with cefoxitin
Descriptor: (2R)-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, SODIUM ION, ...
Authors:Malashkevich, V.N, Toro, R, Lefurgy, S, Almo, S.C.
Deposit date:2015-07-09
Release date:2016-02-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:FOX-4 cephamycinase: an analysis of structure and function.
Antimicrob.Agents Chemother., 2015
5CGW
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BU of 5cgw by Molmil
CRYSTAL STRUCTURE OF Fox-4 cephamycinase mutant Y150F
Descriptor: ACETATE ION, Beta-lactamase, ZINC ION
Authors:Malashkevich, V.N, Toro, R, Lefurgy, S, Almo, S.C.
Deposit date:2015-07-09
Release date:2016-02-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:FOX-4 cephamycinase: an analysis of structure and function.
Antimicrob.Agents Chemother., 2015

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