PDB: 53102 resultsInfo pagesStatus searchChemie searchBIRD

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3T9D	Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP and 5-(PP)-IP5 (5-IP7) Descriptor: (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, Inositol Pyrophosphate Kinase, MAGNESIUM ION, ... Authors: Wang, H, Falck, J, Hall, T.M.T, Shears, S.B. Deposit date: 2011-08-02 Release date: 2011-12-07 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nat.Chem.Biol., 8, 2011
7QTT	Structural organization of a late activated human spliceosome (Baqr, core region) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... Authors: Cretu, C, Pena, V. Deposit date: 2022-01-15 Release date: 2023-05-10 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis of catalytic activation in human splicing. Nature, 617, 2023
3T9A	Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP at pH 7.0 Descriptor: CADMIUM ION, Inositol Pyrophosphate Kinase, MAGNESIUM ION, ... Authors: Wang, H, Falck, J, Hall, T.M.T, Shears, S.B. Deposit date: 2011-08-02 Release date: 2011-12-07 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nat.Chem.Biol., 8, 2011
7V66	Structure of Apoferritin Descriptor: Ferritin heavy chain Authors: Zhang, X, Wu, C, Shi, H. Deposit date: 2021-08-19 Release date: 2022-10-05 Last modified: 2023-08-16 Method: ELECTRON MICROSCOPY (1.89 Å) Cite: Low-cooling-rate freezing in biomolecular cryo-electron microscopy for recovery of initial frames. QRB Discov, 2, 2021
7PFP	Full-length cryo-EM structure of the native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Jovine, L, Xu, C, Stsiapanava, A, Carroni, M, Tunyasuvunakool, K, Jumper, J, Wu, B. Deposit date: 2021-08-11 Release date: 2022-03-16 Last modified: 2022-03-30 Method: ELECTRON MICROSCOPY (6.1 Å) Cite: Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH. Nat.Struct.Mol.Biol., 29, 2022
7T6V	Structure of the human FPR2-Gi complex with fMLFII Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... Authors: Zhuang, Y.W. Deposit date: 2021-12-14 Release date: 2022-03-30 Last modified: 2022-10-19 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Nat Commun, 13, 2022
7T6U	Structure of the human FPR2-Gi complex with CGEN-855A Descriptor: B9-scFv, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Zhuang, Y.W. Deposit date: 2021-12-14 Release date: 2022-03-30 Last modified: 2022-10-19 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Nat Commun, 13, 2022
7T6T	Structure of the human FPR1-Gi complex with fMLFII Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... Authors: Zhuang, Y.W. Deposit date: 2021-12-14 Release date: 2022-03-30 Last modified: 2022-10-19 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Nat Commun, 13, 2022
7SZZ	Structure of the smaller diameter PSMalpha3 nanotubes Descriptor: Phenol-soluble modulin PSM-alpha-3 Authors: Beltran, L.C, Kreutzberger, M.A, Wang, S, Egelman, E.H, Conticello, V.P. Deposit date: 2021-11-29 Release date: 2022-05-18 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Phenol-soluble modulins PSM alpha 3 and PSM beta 2 form nanotubes that are cross-alpha amyloids. Proc.Natl.Acad.Sci.USA, 119, 2022
7T8U	Structure of PSMbeta2 nanotubes Descriptor: Antibacterial protein Authors: Kreutzberger, M.A, Wang, S, Egelman, E.H, Conicello, V.P. Deposit date: 2021-12-17 Release date: 2022-05-18 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Phenol-soluble modulins PSM alpha 3 and PSM beta 2 form nanotubes that are cross-alpha amyloids. Proc.Natl.Acad.Sci.USA, 119, 2022
7T0X	Structure of the larger diameter PSMalpha3 nanotube Descriptor: Phenol-soluble modulin PSM-alpha-3 Authors: Kreutzberger, M.A, Wang, S, Beltran, L.C, Egelman, E.H, Conticello, V.P. Deposit date: 2021-11-30 Release date: 2022-05-18 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Phenol-soluble modulins PSM alpha 3 and PSM beta 2 form nanotubes that are cross-alpha amyloids. Proc.Natl.Acad.Sci.USA, 119, 2022
7TYV	Structure of Lassa Virus glycoprotein (Josiah) bound to Fab 25.10C Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 25.10C Fab Heavy Chain, ... Authors: Enriquez, A.S, Hastie, K.M. Deposit date: 2022-02-14 Release date: 2022-06-01 Last modified: 2022-06-15 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Delineating the mechanism of anti-Lassa virus GPC-A neutralizing antibodies. Cell Rep, 39, 2022
8WZH	Human erythrocyte catalase with SLS as additive during cryo-EM grid preparation Descriptor: Catalase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE Authors: Yadav, S, Vinothkumar, K.R. Deposit date: 2023-11-01 Release date: 2024-07-10 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Factors affecting macromolecule orientations in thin films formed in cryo-EM. Acta Crystallogr D Struct Biol, 80, 2024
7W0M	Cryo-EM structure of a monomeric GPCR-Gi complex with small molecule Descriptor: (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. Deposit date: 2021-11-18 Release date: 2022-07-27 Method: ELECTRON MICROSCOPY (3.71 Å) Cite: Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
7T20	E. coli DnaB bound to ssDNA and AMPPNP Descriptor: DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Oakley, A.J, Xu, Z.Q. Deposit date: 2021-12-02 Release date: 2022-12-14 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Sequence of conformation changes of DnaB helicase during DNA unwinding and priming in Escherichia coli To Be Published
7T6S	Structure of the human FPR2-Gi complex with compound C43 Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... Authors: Zhuang, Y.W. Deposit date: 2021-12-14 Release date: 2022-03-30 Last modified: 2022-10-19 Method: ELECTRON MICROSCOPY (3 Å) Cite: Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Nat Commun, 13, 2022
4W8F	Crystal structure of the dynein motor domain in the AMPPNP-bound state Descriptor: Dynein heavy chain lysozyme chimera, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER Authors: Cheng, H.-C, Bhabha, G, Zhang, N, Vale, R.D. Deposit date: 2014-08-24 Release date: 2014-11-12 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.541 Å) Cite: Allosteric communication in the Dynein motor domain. Cell, 159, 2014
6SIC	Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA Descriptor: CRISPR-associated RAMP protein, Cmr1 family, Cmr4 family, ... Authors: Sofos, N, Montoya, G, Stella, S. Deposit date: 2019-08-09 Release date: 2020-07-08 Last modified: 2020-09-16 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: Structures of the Cmr-beta Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas. Mol.Cell, 79, 2020
8SR5	particulate methane monooxygenase potassium cyanide treated Descriptor: Ammonia monooxygenase/methane monooxygenase, subunit C family protein, COPPER (II) ION, ... Authors: Tucci, F.J, Rosenzweig, A.C. Deposit date: 2023-05-05 Release date: 2023-11-29 Last modified: 2024-01-24 Method: ELECTRON MICROSCOPY (3.22 Å) Cite: Product analog binding identifies the copper active site of particulate methane monooxygenase. Nat Catal, 6, 2023
5SJU	Crystal Structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-N-[4-(piperidin-1-ylmethyl)-1,3-thiazol-2-yl]-3-(pyrimidin-5-ylamino)pyrazine-2-carboxamide Descriptor: 6-cyclopropyl-N-{(4S)-4-[(piperidin-1-yl)methyl]-4,5-dihydro-1,3-thiazol-2-yl}-3-[(pyrimidin-5-yl)amino]pyrazine-2-carboxamide, MAGNESIUM ION, ZINC ION, ... Authors: Joseph, C, Benz, J, Flohr, A, Koerner, M, Rudolph, M.G. Deposit date: 2022-02-01 Release date: 2022-10-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Crystal Structure of a human phosphodiesterase 10 complex To be published
5SFQ	Crystal Structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-N-[1-(2,2-difluoroethyl)pyrazol-3-yl]-2-methylpyrazole-3-carboxamide Descriptor: 4-(azetidine-1-carbonyl)-N-[1-(2,2-difluoroethyl)-1H-pyrazol-3-yl]-1-methyl-1H-pyrazole-5-carboxamide, MAGNESIUM ION, ZINC ION, ... Authors: Joseph, C, Peters, J.U, Benz, J, Schlatter, D, Rudolph, M.G. Deposit date: 2022-01-21 Release date: 2022-10-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.21 Å) Cite: A high quality, industrial data set for binding affinity prediction: performance comparison in different early drug discovery scenarios. J.Comput.Aided Mol.Des., 36, 2022
5SKB	Crystal Structure of human phosphodiesterase 10 in complex with 9-methoxy-3,5-dihydropyrimido[5,4-b]indol-4-one Descriptor: 9-methoxy-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one, MAGNESIUM ION, ZINC ION, ... Authors: Joseph, C, Benz, J, Flohr, A, Brunner, M, Rudolph, M.G. Deposit date: 2022-02-01 Release date: 2022-10-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Crystal Structure of a human phosphodiesterase 10 complex To be published
5SG8	Crystal Structure of human phosphodiesterase 10 in complex with 5-butoxy-4-ethoxypyrimidin-2-amine Descriptor: 5-butoxy-4-ethoxypyrimidin-2-amine, MAGNESIUM ION, ZINC ION, ... Authors: Joseph, C, Benz, J, Flohr, A, Gruessner, A, Rudolph, M.G. Deposit date: 2022-02-01 Release date: 2022-10-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Crystal Structure of a human phosphodiesterase 10 complex To be published
5SGP	Crystal Structure of human phosphodiesterase 10 in complex with 4-N-(2-methoxyethyl)-4-N,2-dimethyl-3-N-(2-phenylimidazo[1,2-a]pyridin-7-yl)pyrazole-3,4-dicarboxamide Descriptor: GLYCEROL, MAGNESIUM ION, N~4~-(2-methoxyethyl)-N~4~,1-dimethyl-N~5~-[(4R)-2-phenylimidazo[1,2-a]pyridin-7-yl]-1H-pyrazole-4,5-dicarboxamide, ... Authors: Joseph, C, Benz, J, Flohr, A, Peters, J, Rudolph, M.G. Deposit date: 2022-02-01 Release date: 2022-10-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure of a human phosphodiesterase 10 complex To be published
5SKR	Crystal Structure of human phosphodiesterase 10 in complex with 1-methyl-N-(2-methyl-5-pyridin-2-ylpyrazol-3-yl)-4-pyridin-4-ylpyrazole-3-carboxamide Descriptor: 1-methyl-N-[1-methyl-3-(pyridin-2-yl)-1H-pyrazol-5-yl]-4-(pyridin-4-yl)-1H-pyrazole-3-carboxamide, MAGNESIUM ION, ZINC ION, ... Authors: Joseph, C, Benz, J, Flohr, A, Koerner, M, Rudolph, M.G. Deposit date: 2022-02-01 Release date: 2022-10-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Crystal Structure of a human phosphodiesterase 10 complex To be published

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