2IO1
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![BU of 2io1 by Molmil](/molmil-images/mine/2io1) | Crystal structure of human Senp2 in complex with preSUMO-3 | Descriptor: | Sentrin-specific protease 2, Small ubiquitin-related modifier 3 precursor | Authors: | Reverter, D, Lima, C.D. | Deposit date: | 2006-10-09 | Release date: | 2006-11-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates. Nat.Struct.Mol.Biol., 13, 2006
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4RKG
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![BU of 4rkg by Molmil](/molmil-images/mine/4rkg) | Structure of the MSL2 CXC domain bound with a non-specific (GC)6 DNA | Descriptor: | DNA (5'-D(*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*C)-3'), E3 ubiquitin-protein ligase msl-2, ZINC ION | Authors: | Zheng, S, Ye, K. | Deposit date: | 2014-10-13 | Release date: | 2015-01-21 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis of X chromosome DNA recognition by the MSL2 CXC domain during Drosophila dosage compensation. Genes Dev., 28, 2014
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4RKH
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![BU of 4rkh by Molmil](/molmil-images/mine/4rkh) | Structure of the MSL2 CXC domain bound with a specific MRE sequence | Descriptor: | DNA (5'-D(*AP*TP*CP*CP*AP*TP*CP*TP*CP*GP*CP*TP*CP*AP*T)-3'), DNA (5'-D(*AP*TP*GP*AP*GP*CP*GP*AP*GP*AP*TP*GP*GP*AP*T)-3'), E3 ubiquitin-protein ligase msl-2, ... | Authors: | Zheng, S, Ye, K. | Deposit date: | 2014-10-13 | Release date: | 2015-01-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of X chromosome DNA recognition by the MSL2 CXC domain during Drosophila dosage compensation. Genes Dev., 28, 2014
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7R2E
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![BU of 7r2e by Molmil](/molmil-images/mine/7r2e) | Structure of human Senp7 with SUMO2 | Descriptor: | Sentrin-specific protease 7, Small ubiquitin-related modifier 3, prop-2-en-1-amine | Authors: | Reverter, D, Li, Y. | Deposit date: | 2022-02-04 | Release date: | 2022-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Structural Basis for the SUMO2 Isoform Specificity of SENP7. J.Mol.Biol., 434, 2022
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7KPB
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![BU of 7kpb by Molmil](/molmil-images/mine/7kpb) | Human TNF-alpha TNFR1 complex bound to conformationally selective antibody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(1-{[2-(difluoromethoxy)phenyl]methyl}-2-{[3-(2-oxopyrrolidin-1-yl)phenoxy]methyl}-1H-benzimidazol-6-yl)pyridin-2(1H)-one, Fab1974 - Heavy Chain, ... | Authors: | Fox III, D, Conrady, D.G, Lowe, M, Ceska, T. | Deposit date: | 2020-11-10 | Release date: | 2021-01-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF Nat Commun, 12, 2021
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7VH4
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![BU of 7vh4 by Molmil](/molmil-images/mine/7vh4) | Crystal structure of oligoribonuclease of Escherichia coli | Descriptor: | ACETATE ION, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | Authors: | Badhwar, P, Taneja, B. | Deposit date: | 2021-09-20 | Release date: | 2022-09-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Three-dimensional structure of a mycobacterial oligoribonuclease reveals a unique C-terminal tail that stabilizes the homodimer. J.Biol.Chem., 298, 2022
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7WIK
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![BU of 7wik by Molmil](/molmil-images/mine/7wik) | |
6XOG
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![BU of 6xog by Molmil](/molmil-images/mine/6xog) | Structure of SUMO1-ML786519 adduct bound to SAE | Descriptor: | SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... | Authors: | Sintchak, M, Lane, W, Bump, N. | Deposit date: | 2020-07-07 | Release date: | 2021-03-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J.Med.Chem., 64, 2021
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6XOH
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![BU of 6xoh by Molmil](/molmil-images/mine/6xoh) | Structure of SUMO1-ML00789344 adduct bound to SAE | Descriptor: | SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... | Authors: | Sintchak, M, Lane, W, Bump, N. | Deposit date: | 2020-07-07 | Release date: | 2021-03-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.226 Å) | Cite: | Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J.Med.Chem., 64, 2021
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6XOI
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![BU of 6xoi by Molmil](/molmil-images/mine/6xoi) | Structure of SUMO1-ML00752641 adduct bound to SAE | Descriptor: | SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... | Authors: | Sintchak, M, Lane, W, Bump, N. | Deposit date: | 2020-07-07 | Release date: | 2021-03-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J.Med.Chem., 64, 2021
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2VRR
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![BU of 2vrr by Molmil](/molmil-images/mine/2vrr) | Structure of SUMO modified Ubc9 | Descriptor: | FORMIC ACID, SMALL UBIQUITIN-RELATED MODIFIER 1, SODIUM ION, ... | Authors: | Knipscheer, P, Flotho, A, Klug, H, Olsen, J.V, van Dijk, W.J, Fish, A, Johnson, E.S, Mann, M, Sixma, T.K, Pichler, A. | Deposit date: | 2008-04-13 | Release date: | 2008-08-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Ubc9 sumoylation regulates SUMO target discrimination. Mol. Cell, 31, 2008
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8ODR
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![BU of 8odr by Molmil](/molmil-images/mine/8odr) | Mimetic of UBC9-SUMO1 | Descriptor: | SULFATE ION, SUMO-conjugating enzyme UBC9, Small ubiquitin-related modifier 1 | Authors: | Coste, F, Goffinont, S, Suskiewicz, M.J. | Deposit date: | 2023-03-09 | Release date: | 2023-06-07 | Last modified: | 2023-07-19 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural insights into the regulation of the human E2∼SUMO conjugate through analysis of its stable mimetic. J.Biol.Chem., 299, 2023
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2XUS
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![BU of 2xus by Molmil](/molmil-images/mine/2xus) | Crystal Structure of the BRMS1 N-terminal region | Descriptor: | BREAST CANCER METASTASIS-SUPPRESSOR 1, CHLORIDE ION, SULFATE ION | Authors: | Spinola-Amilibia, M, Rivera, J, Ortiz-Lombardia, M, Romero, A, Neira, J.L, Bravo, J. | Deposit date: | 2010-10-20 | Release date: | 2011-07-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.912 Å) | Cite: | The Structure of Brms1 Nuclear Export Signal and Snx6 Interacting Region Reveals a Hexamer Formed by Antiparallel Coiled Coils. J.Mol.Biol., 411, 2011
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1Z3C
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![BU of 1z3c by Molmil](/molmil-images/mine/1z3c) | Encephalitozooan cuniculi mRNA Cap (Guanine-N7) Methyltransferasein complexed with AzoAdoMet | Descriptor: | S-5'-AZAMETHIONINE-5'-DEOXYADENOSINE, mRNA CAPPING ENZYME | Authors: | Hausmann, S, Zhang, S, Fabrega, C, Schneller, S.W, Lima, C.D, Shuman, S. | Deposit date: | 2005-03-11 | Release date: | 2005-03-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis. J.Biol.Chem., 280, 2005
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3BGY
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![BU of 3bgy by Molmil](/molmil-images/mine/3bgy) | |
8V9J
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![BU of 8v9j by Molmil](/molmil-images/mine/8v9j) | Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Msmeg1130 (Balon) (Structure 4) | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S14, ... | Authors: | Rybak, M.Y, Helena-Bueno, K, Hill, C.H, Melnikov, S.V, Gagnon, M.G. | Deposit date: | 2023-12-08 | Release date: | 2024-02-07 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | A new family of bacterial ribosome hibernation factors. Nature, 626, 2024
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8V9K
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![BU of 8v9k by Molmil](/molmil-images/mine/8v9k) | Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Rv2629 (Balon) (Structure 5) | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S2, ... | Authors: | Rybak, M.Y, Helena-Bueno, K, Hill, C.H, Melnikov, S.V, Gagnon, M.G. | Deposit date: | 2023-12-08 | Release date: | 2024-02-07 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | A new family of bacterial ribosome hibernation factors. Nature, 626, 2024
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2AWT
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![BU of 2awt by Molmil](/molmil-images/mine/2awt) | Solution Structure of Human Small Ubiquitin-Like Modifier Protein Isoform 2 (SUMO-2) | Descriptor: | Small ubiquitin-related modifier 2 | Authors: | Chang, C.K, Wang, Y.H, Chung, T.L, Chang, C.F, Li, S.S.L, Huang, T.H. | Deposit date: | 2005-09-02 | Release date: | 2006-10-24 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution Structure of Human Small Ubiquitin-Like Modifier Protein Isoform 2 (SUMO-2) To be Published
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4BKG
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![BU of 4bkg by Molmil](/molmil-images/mine/4bkg) | crystal structure of human diSUMO-2 | Descriptor: | SMALL UBIQUITIN-RELATED MODIFIER 2 | Authors: | Keusekotten, K, Bade, V.N, Meyer-Teschendorf, K, Sriramachandran, A, Fischer-Schrader, K, Krause, A, Horst, C, Hofmann, K, Dohmen, R.J, Praefcke, G.J.K. | Deposit date: | 2013-04-25 | Release date: | 2013-11-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Multivalent Interactions of the Sumo-Interaction Motifs in the Ring-Finger Protein 4 (Rnf4) Determine the Specificity for Chains of the Small Ubiquitin-Related Modifier (Sumo). Biochem.J., 457, 2014
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2ASQ
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![BU of 2asq by Molmil](/molmil-images/mine/2asq) | Solution Structure of SUMO-1 in Complex with a SUMO-binding Motif (SBM) | Descriptor: | Protein inhibitor of activated STAT2, Small ubiquitin-related modifier 1 | Authors: | Song, J, Zhang, Z, Hu, W, Chen, Y. | Deposit date: | 2005-08-23 | Release date: | 2005-10-11 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Small Ubiquitin-like Modifier (SUMO) Recognition of a SUMO Binding Motif: A reversal of the bound orientation J.Biol.Chem., 280, 2005
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5K36
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![BU of 5k36 by Molmil](/molmil-images/mine/5k36) | Structure of an eleven component nuclear RNA exosome complex bound to RNA | Descriptor: | Exosome complex component CSL4, Exosome complex component MTR3, Exosome complex component RRP4, ... | Authors: | Lima, C.D, Zinder, J.C. | Deposit date: | 2016-05-19 | Release date: | 2016-11-02 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Nuclear RNA Exosome at 3.1 angstrom Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3. Mol.Cell, 64, 2016
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5KOA
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![BU of 5koa by Molmil](/molmil-images/mine/5koa) | |
2CKH
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![BU of 2ckh by Molmil](/molmil-images/mine/2ckh) | SENP1-SUMO2 complex | Descriptor: | SENTRIN-SPECIFIC PROTEASE 1, SMALL UBIQUITIN-RELATED MODIFIER 2 | Authors: | Shen, L.N, Dong, C, Liu, H, Hay, R.T, Naismith, J.H. | Deposit date: | 2006-04-18 | Release date: | 2006-04-26 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The Structure of Senp1-Sumo-2 Complex Suggests a Structural Basis for Discrimination between Sumo Paralogues During Processing. Biochem.J., 397, 2006
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7ZJV
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![BU of 7zjv by Molmil](/molmil-images/mine/7zjv) | |
7ZJU
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![BU of 7zju by Molmil](/molmil-images/mine/7zju) | |