1T9U
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1T9V
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1T9T
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2HQG
| Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway | Descriptor: | Acriflavine resistance protein B | Authors: | Su, C.-C, Li, M, Gu, R, Takatsuka, Y, McDermott, G, Nikaido, H, Yu, E.W. | Deposit date: | 2006-07-18 | Release date: | 2007-04-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.38 Å) | Cite: | Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway J.Bacteriol., 188, 2006
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2HRT
| Asymmetric structure of trimeric AcrB from Escherichia coli | Descriptor: | Acriflavine resistance protein B, CITRATE ANION | Authors: | Seeger, M.A, Schiefner, A, Eicher, T, Verrey, F, Diederichs, K, Pos, K.M. | Deposit date: | 2006-07-20 | Release date: | 2006-09-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism. Science, 313, 2006
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8DEV
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2J8S
| Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors | Descriptor: | ACRIFLAVINE RESISTANCE PROTEIN B, DARPIN, DODECYL-ALPHA-D-MALTOSIDE, ... | Authors: | Sennhauser, G, Amstutz, P, Briand, C, Storchenegger, O, Gruetter, M.G. | Deposit date: | 2006-10-27 | Release date: | 2007-01-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Drug Export Pathway of Multidrug Exporter Acrb Revealed by Darpin Inhibitors. Plos Biol., 5, 2007
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8DEU
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8FFK
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8FFS
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6SGU
| Cryo-EM structure of Escherichia coli AcrB and DARPin in Saposin A-nanodisc | Descriptor: | DARPin, Multidrug efflux pump subunit AcrB | Authors: | Szewczak-Harris, A, Du, D, Newman, C, Neuberger, A, Luisi, B.F. | Deposit date: | 2019-08-05 | Release date: | 2020-05-13 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment. Structure, 28, 2020
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6SGT
| Cryo-EM structure of Escherichia coli AcrB and DARPin in Saposin A-nanodisc with cardiolipin | Descriptor: | DARPin, Multidrug efflux pump subunit AcrB | Authors: | Szewczak-Harris, A, Du, D, Newman, C, Neuberger, A, Luisi, B.F. | Deposit date: | 2019-08-05 | Release date: | 2020-05-13 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment. Structure, 28, 2020
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8GJK
| Multi-drug efflux pump RE-CmeB bound with ampicillin | Descriptor: | (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Efflux pump membrane transporter | Authors: | Zhang, Z. | Deposit date: | 2023-03-16 | Release date: | 2023-05-31 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance. Microbiol Spectr, 11, 2023
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8GK4
| Multi-drug efflux pump RE-CmeB bound with Chloramphenicol | Descriptor: | CHLORAMPHENICOL, Efflux pump membrane transporter | Authors: | Zhang, Z. | Deposit date: | 2023-03-17 | Release date: | 2023-05-31 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance. Microbiol Spectr, 11, 2023
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8GK0
| Multi-drug efflux pump RE-CmeB bound with Erythromycin | Descriptor: | ERYTHROMYCIN A, Efflux pump membrane transporter | Authors: | Zhang, Z. | Deposit date: | 2023-03-16 | Release date: | 2023-06-07 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance. Microbiol Spectr, 11, 2023
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5ENP
| MBX2931 bound structure of bacterial efflux pump. | Descriptor: | 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | Authors: | Sjuts, H, Ornik, A.R, Pos, K.M. | Deposit date: | 2015-11-09 | Release date: | 2016-04-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives. Proc.Natl.Acad.Sci.USA, 113, 2016
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5ENQ
| MBX3132 bound structure of bacterial efflux pump. | Descriptor: | DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB, ~{N}-[4-[2-[[5-cyano-8-[(2~{S},6~{R})-2,6-dimethylmorpholin-4-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridin-6-yl]sulfanyl]ethyl]phenyl]ethanamide | Authors: | Sjuts, H, Ornik, A.R, Pos, K.M. | Deposit date: | 2015-11-09 | Release date: | 2016-04-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives. Proc.Natl.Acad.Sci.USA, 113, 2016
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8GJL
| multi-drug efflux pump RE-CmeB bound with Ciprofloxacin | Descriptor: | 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, Efflux pump membrane transporter | Authors: | Zhang, Z. | Deposit date: | 2023-03-16 | Release date: | 2023-05-31 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance. Microbiol Spectr, 11, 2023
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8GJJ
| Multi-drug efflux pump RE-CmeB Apo form | Descriptor: | Efflux pump membrane transporter | Authors: | Zhang, Z. | Deposit date: | 2023-03-15 | Release date: | 2023-05-31 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance. Microbiol Spectr, 11, 2023
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5ENT
| Minocycline bound structure of bacterial efflux pump. | Descriptor: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, DARPin, DI(HYDROXYETHYL)ETHER, ... | Authors: | Sjuts, H, Ornik, A.R, Pos, K.M. | Deposit date: | 2015-11-09 | Release date: | 2016-04-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives. Proc.Natl.Acad.Sci.USA, 113, 2016
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8F56
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8F4N
| Dimer of aminoglycoside efflux pump AcrD | Descriptor: | Efflux pump membrane transporter | Authors: | Zhang, Z. | Deposit date: | 2022-11-11 | Release date: | 2022-12-28 | Last modified: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity. Mbio, 14, 2023
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8F4R
| Gentamicin bound aminoglycoside efflux pump AcrD | Descriptor: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, Efflux pump membrane transporter | Authors: | Zhang, Z. | Deposit date: | 2022-11-11 | Release date: | 2022-12-28 | Last modified: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity. Mbio, 14, 2023
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8F3E
| Trimer of aminoglycoside efflux pump AcrD | Descriptor: | Efflux pump membrane transporter | Authors: | Zhang, Z. | Deposit date: | 2022-11-10 | Release date: | 2022-12-28 | Last modified: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity. Mbio, 14, 2023
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5ENR
| MBX3135 bound structure of bacterial efflux pump. | Descriptor: | DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB, ~{N}-[4-[2-[[5-cyano-8-[(2~{S},6~{S})-2,6-dimethylmorpholin-4-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridin-6-yl]sulfanyl]ethyl]phenyl]prop-2-enamide | Authors: | Sjuts, H, Ornik, A.R, Pos, K.M. | Deposit date: | 2015-11-09 | Release date: | 2016-04-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives. Proc.Natl.Acad.Sci.USA, 113, 2016
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