8AHM
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![BU of 8ahm by Molmil](/molmil-images/mine/8ahm) | Crystal structure of tubulin in complex with C(13)/C(13')-Bis-Desmethyl-Disorazole Z | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DIMETHYL SULFOXIDE, ... | Authors: | Oliva, M.A, Diaz, J.F, Altmann, K.H. | Deposit date: | 2022-07-22 | Release date: | 2022-11-16 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Synthesis and Biological Evaluation of C(13)/C(13')-Bis(desmethyl)disorazole Z. Angew.Chem.Int.Ed.Engl., 62, 2023
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7YHN
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![BU of 7yhn by Molmil](/molmil-images/mine/7yhn) | ANTI-TUMOR AGENT Y48 IN COMPLEX WITH TUBULIN | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-methyl-3-[(4-methylphenyl)sulfonylamino]-~{N}-[(6-methylpyridin-3-yl)methyl]benzamide, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Du, T, Ji, M, Hou, Z, Lin, S, Zhang, J, Wu, D, Zhang, K, Lu, D, Xu, H, Chen, X. | Deposit date: | 2022-07-14 | Release date: | 2023-07-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site. J.Med.Chem., 65, 2022
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8A9Z
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![BU of 8a9z by Molmil](/molmil-images/mine/8a9z) | Tubulin-[1,2]oxazoloisoindole-2e complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 7-[(3,5-dimethoxyphenyl)methyl]pyrrolo[3,4-g][1,2]benzoxazole, CALCIUM ION, ... | Authors: | Prota, A.E, Abel, A.-C, Steinmetz, M.O, Barraja, P, Montalbano, A, Spano, V. | Deposit date: | 2022-06-29 | Release date: | 2022-11-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.294 Å) | Cite: | Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas. Eur.J.Med.Chem., 243, 2022
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8DIQ
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![BU of 8diq by Molmil](/molmil-images/mine/8diq) | Tubulin-RB3_SLD-TTL in complex with SB226 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[2-(ethylamino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, CALCIUM ION, ... | Authors: | White, S.W, Yun, M. | Deposit date: | 2022-06-29 | Release date: | 2023-01-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.395 Å) | Cite: | SB226, an inhibitor of tubulin polymerization, inhibits paclitaxel-resistant melanoma growth and spontaneous metastasis. Cancer Lett., 555, 2022
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8A9T
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![BU of 8a9t by Molmil](/molmil-images/mine/8a9t) | Tubulin-[1,2]oxazoloisoindole-1 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Prota, A.E, Abel, A.-C, Steinmetz, M.O, Barraja, P, Montalbano, A, Spano, V. | Deposit date: | 2022-06-29 | Release date: | 2022-11-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.304 Å) | Cite: | Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas. Eur.J.Med.Chem., 243, 2022
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8A0L
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![BU of 8a0l by Molmil](/molmil-images/mine/8a0l) | Tubulin-CW1-complex | Descriptor: | (3~{S},4~{R},8~{S},10~{S},12~{S},14~{S})-14-[(~{Z},4~{R})-4-(hydroxymethyl)hex-2-en-2-yl]-4,12-dimethoxy-9,9-dimethyl-3,8,10-tris(oxidanyl)-1-oxacyclotetradecan-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Prota, A.E, Diaz, J.F, Steinmetz, M.O, Oliva, M.A. | Deposit date: | 2022-05-28 | Release date: | 2022-12-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9981 Å) | Cite: | Chemical modulation of microtubule structure through the laulimalide/peloruside site. Structure, 31, 2023
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7ZYW
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![BU of 7zyw by Molmil](/molmil-images/mine/7zyw) | Crystal structure of T2R-TTL-PM534 complex | Descriptor: | (4R)-N-[(1R)-1-[4-(cyclopropylmethoxy)-6-oxidanylidene-pyran-2-yl]butyl]-4-methyl-2-[(E)-C-methyl-N-oxidanyl-carbonimidoyl]-5H-1,3-thiazole-4-carboxamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Oliva, M.A, Diaz, J.F, Cuevas, C. | Deposit date: | 2022-05-25 | Release date: | 2023-11-29 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin. J.Med.Chem., 67, 2024
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7ZX2
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![BU of 7zx2 by Molmil](/molmil-images/mine/7zx2) | Tubulin-Pelophen B complex | Descriptor: | (3R,4S,7S,9S,11S)-3,4,11-trihydroxy-7-((R,Z)-4-(hydroxymethyl)hex-2-en-2-yl)-9-methoxy-12,12-dimethyl-6-oxa-1(1,3)-benzenacyclododecaphan-5-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Estevez-Gallego, J, Diaz, J.F, Van der Eycken, J, Oliva, M.A. | Deposit date: | 2022-05-20 | Release date: | 2022-11-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Chemical modulation of microtubule structure through the laulimalide/peloruside site. Structure, 31, 2023
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7XQX
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![BU of 7xqx by Molmil](/molmil-images/mine/7xqx) | Crystal structure of T2R-TTL-27a complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloranyl-7-fluoranyl-N-(4-methoxyphenyl)-N-methyl-quinazolin-4-amine, CALCIUM ION, ... | Authors: | Lun, T, Wu, C.Y. | Deposit date: | 2022-05-09 | Release date: | 2023-05-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.36 Å) | Cite: | Crystal structure of T2R-TT complex To Be Published
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7XQY
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![BU of 7xqy by Molmil](/molmil-images/mine/7xqy) | Crystal structure of T2R-TTL-15 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloranyl-N-(4-methoxyphenyl)-N-methyl-pyrido[3,2-d]pyrimidin-4-amine, CALCIUM ION, ... | Authors: | Lun, T, ChengYong, W. | Deposit date: | 2022-05-09 | Release date: | 2023-05-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structure of T2R-TTL-15 complex To Be Published
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7XR0
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![BU of 7xr0 by Molmil](/molmil-images/mine/7xr0) | Crystal structure of T2R-TTL-27a complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloranyl-5-fluoranyl-N-(4-methoxyphenyl)-N-methyl-quinazolin-4-amine, CALCIUM ION, ... | Authors: | Lun, T, Wu, C.Y. | Deposit date: | 2022-05-09 | Release date: | 2023-05-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of T2R-TTL-27a complex To Be Published
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7XR1
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![BU of 7xr1 by Molmil](/molmil-images/mine/7xr1) | Crystal structure of T2R-TTL-3a complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloranyl-6-fluoranyl-N-(4-methoxyphenyl)-N-methyl-quinazolin-4-amine, CALCIUM ION, ... | Authors: | Lun, T, Wu, C.Y. | Deposit date: | 2022-05-09 | Release date: | 2023-05-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Crystal structure of T2R-TTL-3a complex To Be Published
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7UNG
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![BU of 7ung by Molmil](/molmil-images/mine/7ung) | 48-nm repeat of the human respiratory doublet microtubule | Descriptor: | Cilia- and flagella-associated protein 161, Cilia- and flagella-associated protein 20, Cilia- and flagella-associated protein 45, ... | Authors: | Gui, M, Croft, J.T, Zabeo, D, Acharya, V, Kollman, J.M, Burgoyne, T, Hoog, J.L, Brown, A. | Deposit date: | 2022-04-11 | Release date: | 2022-10-05 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules. Proc.Natl.Acad.Sci.USA, 119, 2022
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7UN1
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![BU of 7un1 by Molmil](/molmil-images/mine/7un1) | 8-nm repeat of the human sperm tip singlet microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Gui, M, Croft, J.T, Zabeo, D, Acharya, V, Kollman, J.M, Burgoyne, T, Hoog, J.L, Brown, A. | Deposit date: | 2022-04-08 | Release date: | 2022-10-05 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (6 Å) | Cite: | SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules. Proc.Natl.Acad.Sci.USA, 119, 2022
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7ZCW
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![BU of 7zcw by Molmil](/molmil-images/mine/7zcw) | Cryo-EM structure of GMPCPP-microtubules in complex with VASH2-SVBP | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | Authors: | Choi, S.R, Blum, T, Steinmetz, M.O. | Deposit date: | 2022-03-29 | Release date: | 2022-12-14 | Last modified: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | VASH1-SVBP and VASH2-SVBP generate different detyrosination profiles on microtubules. J.Cell Biol., 222, 2023
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7Z7D
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![BU of 7z7d by Molmil](/molmil-images/mine/7z7d) | Tubulin-Todalam-Vinblastine-complex | Descriptor: | (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Muehlethaler, T, Milanos, L, Ortega, J.A, Blum, T.B, Gioia, D, Roy, B, Prota, A.E, Cavalli, A, Steinmetz, M.O. | Deposit date: | 2022-03-15 | Release date: | 2022-04-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action. Angew.Chem.Int.Ed.Engl., 61, 2022
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7Z6S
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![BU of 7z6s by Molmil](/molmil-images/mine/7z6s) | MATCAP bound to a human 14 protofilament microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Bak, J, Perrakis, A. | Deposit date: | 2022-03-14 | Release date: | 2022-05-11 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Posttranslational modification of microtubules by the MATCAP detyrosinase. Science, 376, 2022
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7X4N
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![BU of 7x4n by Molmil](/molmil-images/mine/7x4n) | Crystal Structure of C. elegans kinesin-4 KLP-12 complexed with tubulin and DARPin | Descriptor: | DARPin, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Taguchi, S, Imasaki, T, Saijo-Hamano, Y, Sakai, N, Nitta, R. | Deposit date: | 2022-03-03 | Release date: | 2022-09-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 -tubulin complex. Elife, 11, 2022
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7Z2P
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![BU of 7z2p by Molmil](/molmil-images/mine/7z2p) | Tubulin-nocodazole complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Prota, A.E, Muehlethaler, T, Cavalli, A, Steinmetz, M.O. | Deposit date: | 2022-02-28 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents. Eur.J.Med.Chem., 241, 2022
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7Z2N
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![BU of 7z2n by Molmil](/molmil-images/mine/7z2n) | Tubulin-18-complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Muehlethaler, T, Prota, A.E, Cavalli, A, Steinmetz, M.O. | Deposit date: | 2022-02-28 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents. Eur.J.Med.Chem., 241, 2022
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7Z2A
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![BU of 7z2a by Molmil](/molmil-images/mine/7z2a) | P. berghei kinesin-8B motor domain in no nucleotide state bound to tubulin dimer | Descriptor: | Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-8, ... | Authors: | Liu, T, Shilliday, F, Cook, A.D, Moores, C.A. | Deposit date: | 2022-02-26 | Release date: | 2022-10-19 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission. Nat Commun, 13, 2022
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7Z2C
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![BU of 7z2c by Molmil](/molmil-images/mine/7z2c) | P. falciparum kinesin-8B motor domain in no nucleotide bound to tubulin dimer | Descriptor: | Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein, ... | Authors: | Liu, T, Shilliday, F, Cook, A.D, Moores, C.A. | Deposit date: | 2022-02-26 | Release date: | 2022-10-19 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission. Nat Commun, 13, 2022
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7Z2B
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![BU of 7z2b by Molmil](/molmil-images/mine/7z2b) | P. berghei kinesin-8B motor domain in AMPPNP state bound to tubulin dimer | Descriptor: | Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-8, ... | Authors: | Liu, T, Shilliday, F, Cook, A.D, Moores, C.A. | Deposit date: | 2022-02-26 | Release date: | 2022-11-16 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission. Nat Commun, 13, 2022
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7X0S
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![BU of 7x0s by Molmil](/molmil-images/mine/7x0s) | Human TRiC-tubulin-S3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | Authors: | Cong, Y, Liu, C.X. | Deposit date: | 2022-02-22 | Release date: | 2023-04-12 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM. Commun Biol, 6, 2023
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7Z01
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![BU of 7z01 by Molmil](/molmil-images/mine/7z01) | Z-SBTubA4 photoswitch bound to tubulin-DARPin D1 complex | Descriptor: | 2-methoxy-5-[2-(5,6,7-trimethoxy-1,3-benzothiazol-2-yl)ethyl]phenol, CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ... | Authors: | Wranik, M, Weinert, T, Standfuss, J, Steinmetz, M. | Deposit date: | 2022-02-21 | Release date: | 2022-03-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M. J.Am.Chem.Soc., 144, 2022
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