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7MZ0	Structure of human DNA polymerase beta complexed with dzA as the template base in a 1-nucleotide gapped DNA Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*(4DU)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... Authors: Koag, M.-C, Lee, S. Deposit date: 2021-05-23 Release date: 2022-05-25 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.021 Å) Cite: Structure Of Human Dna Polymerase Beta Complexed With dzA As The Template Base In A 1-Nucleotide Gapped Dna To Be Published
7MZ4	Structure of human DNA polymerase beta complexed with 3-deaza-3-methyladenine (3dMeA) in the template base paired with incoming dTTP Descriptor: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*CP*CP*GP*AP*CP*(DZM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... Authors: Koag, M.-C, Lee, S. Deposit date: 2021-05-24 Release date: 2022-06-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.076 Å) Cite: Structure of human DNA polymerase beta complexed with 3-deaza-3-methyladenine (3dMeA) in the template base paired with incoming dTTP To Be Published
7MZ8	Structure of human DNA polymerase beta complexed with 3-deaza-3-methyladenine (3dMeA) at N-1 of the template base paired with incoming dTTP Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*GP*(DZM)P*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*T)-3'), ... Authors: Koag, M.-C, Lee, S. Deposit date: 2021-05-24 Release date: 2022-06-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure Of Human Dna Polymerase Beta Complexed With 8Oa As The Template Base In A 1-Nucleotide Gapped Dna To Be Published
7MZ3	Structure of human DNA polymerase beta complexed with 3-deaza-3-methyladenine (3dMeA) as the template base in a 1-nucleotide gapped DNA Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*(DZM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... Authors: Koag, M.-C, Lee, S. Deposit date: 2021-05-24 Release date: 2022-06-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.418 Å) Cite: Structure of human DNA polymerase beta complexed with 3-deaza-3-methyladenine (3dMeA) as the template base in a 1-nucleotide gapped DNA To Be Published
8G18	Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-108 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... Authors: Regan, M.C, Furukawa, H. Deposit date: 2023-02-01 Release date: 2023-03-01 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model. Acs Chem Neurosci, 14, 2023
7N4P	Crystal Structure of Lizard Cadherin-23 EC1-2 Descriptor: CALCIUM ION, Cadherin 23, SODIUM ION Authors: Nisler, C.R, Sotomayor, M. Deposit date: 2021-06-04 Release date: 2022-06-15 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.097 Å) Cite: Interpreting the Evolutionary Echoes of a Protein Complex Essential for Inner-Ear Mechanosensation. Mol.Biol.Evol., 40, 2023
8FYN	MicroED structure of A2A from plasma milled lamellae Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, ... Authors: Martynowycz, M.W, Shiriaeva, A, Clabbers, M.T.B, Nicolas, W.J, Weaver, S.J, Hattne, J, Gonen, T. Deposit date: 2023-01-26 Release date: 2023-03-08 Last modified: 2023-03-22 Method: ELECTRON CRYSTALLOGRAPHY (2 Å) Cite: A robust approach for MicroED sample preparation of lipidic cubic phase embedded membrane protein crystals. Nat Commun, 14, 2023
2ENI	Mutant F197M structure of PH0725 from Pyrococcus horikoshii OT3 Descriptor: S-ADENOSYL-L-HOMOCYSTEINE, SODIUM ION, diphthine synthase Authors: Shimizu, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-03-28 Release date: 2007-10-02 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Mutant F197M structure of PH0725 from Pyrococcus horikoshii OT3 To be Published
8FFE	Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide Descriptor: GLYCEROL, Low-density lipoprotein receptor-related protein 6, SODIUM ION, ... Authors: Jude, K.M, Tsutsumi, N, Waghray, D, Garcia, K.C. Deposit date: 2022-12-08 Release date: 2023-03-08 Last modified: 2023-03-22 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proc.Natl.Acad.Sci.USA, 120, 2023
8PHA	O(S)-methyltransferase from Pleurotus sapidus Descriptor: 2-HYDROXY BUTANE-1,4-DIOL, GLYCEROL, L-ornithine, ... Authors: Korf, L, Essen, L.-O. Deposit date: 2023-06-19 Release date: 2024-03-27 Last modified: 2024-04-10 Method: X-RAY DIFFRACTION (2.02 Å) Cite: A Novel O - and S -Methyltransferase from Pleurotus sapidus Is Involved in Flavor Formation. J.Agric.Food Chem., 72, 2024
8FD7	Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with gabapentin Descriptor: (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Chen, Z, Mondal, A, Minor, D.L. Deposit date: 2022-12-02 Release date: 2023-03-22 Last modified: 2023-07-05 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis for Ca V alpha 2 delta :gabapentin binding. Nat.Struct.Mol.Biol., 30, 2023
8PMG	Structure of Nal1 indica cultivar IR64, construct 36-458 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... Authors: Huang, L.Y, Rety, S, Xi, X.G. Deposit date: 2023-06-28 Release date: 2024-04-17 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (3.29 Å) Cite: The catalytic triad of rice NARROW LEAF1 involves H234. Nat.Plants, 10, 2024
7N4K	6218 TCR in complex with H2-Db PA 224 Descriptor: Beta-2-microglobulin, Fusion protein of T cell receptor alpha variable 21-DV12 and T-cell receptor, sp3.4 alpha chain, ... Authors: Szeto, C, Gras, S. Deposit date: 2021-06-04 Release date: 2022-07-20 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus. Nat Commun, 13, 2022
7N5C	6218 TCR in complex with H2Db PA with an engineered TCR-pMHC disulfide bond Descriptor: Beta-2-microglobulin, Fusion protein of T cell receptor alpha variable 21-DV12 with T-cell receptor, sp3.4 alpha chain, ... Authors: Szeto, C, Gras, S. Deposit date: 2021-06-05 Release date: 2022-07-20 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus. Nat Commun, 13, 2022
7N5P	6218 TCR in complex with H2-Db PA224-233 with a cysteine mutant Descriptor: Beta-2-microglobulin, Fusion protein of T cell receptor alpha variable 21-DV12 and T-cell receptor, sp3.4 alpha chain, ... Authors: Szeto, C, Gras, S. Deposit date: 2021-06-06 Release date: 2022-07-20 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus. Nat Commun, 13, 2022
7N5Q	Peptide-MHC complex of mouse H2-Db presenting PA224 with E4C mutation Descriptor: ACETATE ION, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... Authors: Szeto, C, Gras, S. Deposit date: 2021-06-06 Release date: 2022-07-20 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus. Nat Commun, 13, 2022
2EHU	Crystal analysis of 1-pyrroline-5-carboxylate dehydrogenase from thermus with bound NAD and Inhibitor L-serine Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1-pyrroline-5-carboxylate dehydrogenase, ACETATE ION, ... Authors: Inagaki, E, Sakamoto, K, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-03-09 Release date: 2007-09-11 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal Structure Analysis of delta1-pyrroline-5-carboxylate dehydrogenase in ternary complex with inhibitor and NAD. To be Published
2EIX	The Structure of Physarum polycephalum cytochrome b5 reductase Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, IODIDE ION, ... Authors: Kim, S.W, Suga, M, Ogasahara, K, Ikegami, T, Minami, Y, Yubisui, T, Tsukihara, T. Deposit date: 2007-03-14 Release date: 2007-04-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Structure of Physarum polycephalum cytochrome b5 reductase at 1.56 A resolution. Acta Crystallogr.,Sect.F, 63, 2007
2EJ6	Crystal analysis of delta1-pyrroline-5-carboxylate dehydrogenase from Thermus thermophilus with bound D-proline Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1-pyrroline-5-carboxylate dehydrogenase, ACETATE ION, ... Authors: Inagaki, E, Sakamoto, K, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-03-15 Release date: 2007-09-18 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Crystal structure analysis of delta1-pyrroline-5-carboxylate dehydrogenase in ternary complex with inhibitor and NAD To be Published
8FHJ	Crystal structure of a FAD monooxygenease from Methylocystis sp. Strain SB2 Descriptor: BROMIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... Authors: Stewart, A.M, Sawaya, M.R, Stewart, C.E. Deposit date: 2022-12-14 Release date: 2023-05-03 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.61 Å) Cite: Crystal structure of MbnF: an NADPH-dependent flavin monooxygenase from Methylocystis strain SB2. Acta Crystallogr.,Sect.F, 79, 2023
7NBB	Branched Lys48- and Lys63-linked tri-ubiquitin (K48-K63-Ub3) in complex with synthetic nanobody NbSL3 Descriptor: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... Authors: Lange, S.M, Kulathu, Y. Deposit date: 2021-01-26 Release date: 2022-08-10 Last modified: 2024-07-31 Method: X-RAY DIFFRACTION (1.55 Å) Cite: VCP/p97-associated proteins are binders and debranching enzymes of K48-K63-branched ubiquitin chains. Nat.Struct.Mol.Biol., 2024
2EII	Crystal analysis of delta1-pyrroline-5-carboxylate dehydrogenase from Thermus thermophilus with bound L-valine and NAD. Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1-pyrroline-5-carboxylate dehydrogenase, ACETATE ION, ... Authors: Inagaki, E, Sakamoto, K, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-03-13 Release date: 2007-09-18 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Crystal structure analysis of delta1-pyrroline-5-carboxylate dehydrogenase in ternary complex with inhibitor and NAD. To be Published
7MXR	Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (r-2) Descriptor: DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), Exonuclease 1, ... Authors: Shi, Y, Beese, L.S. Deposit date: 2021-05-19 Release date: 2023-05-10 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.101 Å) Cite: Structures of reaction intermediates reveal transient Mg2+-binding events that dynamically coordinate Human Exonuclease I activities To Be Published
7MXS	Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (cr) Descriptor: DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), Exonuclease 1, ... Authors: Shi, Y, Beese, L.S. Deposit date: 2021-05-19 Release date: 2023-05-10 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.798 Å) Cite: Structures of reaction intermediates reveal transient Mg2+-binding events that dynamically coordinate Human Exonuclease I activities To Be Published
7MXU	Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' flap DNA (cf2) Descriptor: DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*A)-3'), DNA (5'-D(P*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), Exonuclease 1, ... Authors: Shi, Y, Beese, L.S. Deposit date: 2021-05-19 Release date: 2023-05-10 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.042 Å) Cite: Structures of reaction intermediates reveal transient Mg2+-binding events that dynamically coordinate Human Exonuclease I activities To Be Published

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