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6QJ7	Difluorophenyl diacylhydrazides: Potent inhibitors of Serum- and Glucocorticoid-inducible Kinase 1 (SGK1) Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ~{N}'-[(2~{S})-2-[3,5-bis(fluoranyl)phenyl]-2-oxidanyl-ethanoyl]-2-ethyl-3-methyl-4-oxidanyl-benzohydrazide Authors: Graedler, U. Deposit date: 2019-01-23 Release date: 2020-02-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Difluorophenyl diacylhydrazides: Potent inhibitors of Serum- and Glucocorticoid-inducible Kinase 1 (SGK1) To Be Published
4KXC	Crystal structure of human aminopeptidase A complexed with glutamate Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Yang, Y, Liu, C, Lin, Y.Y, Li, F. Deposit date: 2013-05-25 Release date: 2013-07-31 Last modified: 2022-12-21 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural insights into central hypertension regulation by human aminopeptidase a. J.Biol.Chem., 288, 2013
4KXD	Crystal structure of human aminopeptidase A complexed with glutamate and calcium Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Yang, Y, Liu, C, Lin, Y.Y, Li, F. Deposit date: 2013-05-25 Release date: 2013-07-31 Last modified: 2022-12-21 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural insights into central hypertension regulation by human aminopeptidase a. J.Biol.Chem., 288, 2013
4KXA	Crystal structure of human aminopeptidase A complexed with aspartate and calcium Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Yang, Y, Liu, C, Lin, Y.Y, Li, F. Deposit date: 2013-05-24 Release date: 2013-07-31 Last modified: 2022-12-21 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural insights into central hypertension regulation by human aminopeptidase a. J.Biol.Chem., 288, 2013
4KX9	Crystal structure of human aminopeptidase A complexed with arginine Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Yang, Y, Liu, C, Lin, Y.Y, Li, F. Deposit date: 2013-05-24 Release date: 2013-07-31 Last modified: 2022-12-21 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structural insights into central hypertension regulation by human aminopeptidase a. J.Biol.Chem., 288, 2013
4KX8	Crystal structure of human aminopeptidase A complexed with amastatin Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Yang, Y, Liu, C, Lin, Y.Y, Li, F. Deposit date: 2013-05-24 Release date: 2013-07-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural insights into central hypertension regulation by human aminopeptidase a. J.Biol.Chem., 288, 2013
4KXB	Crystal structure of human aminopeptidase A complexed with bestatin Descriptor: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Yang, Y, Liu, C, Lin, Y.Y, Li, F. Deposit date: 2013-05-24 Release date: 2013-07-31 Last modified: 2022-12-21 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural insights into central hypertension regulation by human aminopeptidase a. J.Biol.Chem., 288, 2013
4KX7	Crystal structure of human aminopeptidase A Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Yang, Y, Liu, C, Lin, Y.Y, Li, F. Deposit date: 2013-05-24 Release date: 2013-07-31 Last modified: 2022-12-21 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural insights into central hypertension regulation by human aminopeptidase a. J.Biol.Chem., 288, 2013
1W7V	ZnMg substituted aminopeptidase P from E. coli Descriptor: CHLORIDE ION, MAGNESIUM ION, PEPTIDE VAL-PRO-LEU, ... Authors: Graham, S.C, Bond, C.S, Freeman, H.C, Guss, J.M. Deposit date: 2004-09-13 Release date: 2005-09-29 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural and Functional Implications of Metal Ion Selection in Aminopeptidase P, a Metalloprotease with a Dinuclear Metal Center. Biochemistry, 44, 2005
1W2M	Ca-substituted form of E. coli aminopeptidase P Descriptor: CALCIUM ION, CHLORIDE ION, ISOPROPYL ALCOHOL, ... Authors: Graham, S.C, Bond, C.S, Freeman, H.C, Guss, J.M. Deposit date: 2004-07-07 Release date: 2005-09-29 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural and Functional Implications of Metal Ion Selection in Aminopeptidase P, a Metalloprotease with a Dinuclear Metal Center. Biochemistry, 44, 2005
4F5C	Crystal structure of the spike receptor binding domain of a porcine respiratory coronavirus in complex with the pig aminopeptidase N ectodomain Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... Authors: Santiago, C, Reguera, J, Gaurav, M, Ordono, D, Enjuanes, L, Casasnovas, J.M. Deposit date: 2012-05-13 Release date: 2012-08-22 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies. Plos Pathog., 8, 2012
4FLL	Human MetAP1 with bengamide analog YZ6, in Mn form Descriptor: (E,2R,3R,4S,5R)-N-[(3R)-3-(furan-2-yl)-3-phenyl-propyl]-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide, MANGANESE (II) ION, Methionine aminopeptidase 1, ... Authors: Ye, Q.Z, Xu, W. Deposit date: 2012-06-14 Release date: 2012-09-19 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases. J.Med.Chem., 55, 2012
4OU3	Crystal structure of porcine aminopeptidase N complexed with CNGRCG tumor-homing peptide Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... Authors: Liu, C, Yang, Y, Chen, L, Lin, Y.-L, Li, F. Deposit date: 2014-02-14 Release date: 2014-11-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.95 Å) Cite: A Unified Mechanism for Aminopeptidase N-based Tumor Cell Motility and Tumor-homing Therapy. J.Biol.Chem., 289, 2014
2GG0	Novel bacterial methionine aminopeptidase inhibitors Descriptor: COBALT (II) ION, METHYL N-{(2S,3R)-3-AMINO-2-HYDROXY-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOYL}ALANYLGLYCINATE, Methionine aminopeptidase, ... Authors: Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M. Deposit date: 2006-03-23 Release date: 2006-06-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors. Proteins, 66, 2007
2GGB	Novel bacterial methionine aminopeptidase inhibitors Descriptor: COBALT (II) ION, METHYL N-[(2S,3R)-3-AMINO-2-HYDROXYHEPTANOYL]-L-SERYL-L-LEUCINATE, Methionine aminopeptidase, ... Authors: Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M. Deposit date: 2006-03-23 Release date: 2006-06-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors. Proteins, 66, 2007
2GG2	Novel bacterial methionine aminopeptidase inhibitors Descriptor: 5-IMINO-4-(3-TRIFLUOROMETHYL-PHENYLAZO)-5H-PYRAZOL-3-YLAMINE, COBALT (II) ION, Methionine aminopeptidase, ... Authors: Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M. Deposit date: 2006-03-23 Release date: 2006-06-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1 Å) Cite: Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors. Proteins, 66, 2007
2G6P	Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with Pyridyl pyrimidine derivative Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE, COBALT (II) ION, ... Authors: Addlagatta, A, Hu, X, Liu, J.O, Matthews, B.W. Deposit date: 2006-02-24 Release date: 2006-06-20 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Identification of Pyridinylpyrimidines as Inhibitors of Human Methionine Aminopeptidases. Angew.Chem.Int.Ed.Engl., 45, 2006
2GG7	Novel bacterial methionine aminopeptidase inhibitors Descriptor: 3-(5-AMINO-3-IMINO-3H-PYRAZOL-4-YLAZO)-BENZOIC ACID, COBALT (II) ION, Methionine aminopeptidase, ... Authors: Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M. Deposit date: 2006-03-23 Release date: 2006-06-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.12 Å) Cite: Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors. Proteins, 66, 2007
2GG8	Novel bacterial methionine aminopeptidase inhibitors Descriptor: COBALT (II) ION, METHYL N-[(2S,3R)-3-AMINO-2-HYDROXY-3-(4-METHYLPHENYL)PROPANOYL]-D-ALANYL-D-LEUCINATE, Methionine aminopeptidase, ... Authors: Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M. Deposit date: 2006-03-23 Release date: 2006-06-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors. Proteins, 66, 2007
2GA2	h-MetAP2 complexed with A193400 Descriptor: 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID, MANGANESE (II) ION, Methionine aminopeptidase 2 Authors: Park, C. Deposit date: 2006-03-07 Release date: 2007-03-13 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. Bioorg.Med.Chem.Lett., 16, 2006
2GG5	Novel bacterial methionine aminopeptidase inhibitors Descriptor: 5-IMINO-4-(2-TRIFLUOROMETHYL-PHENYLAZO)-5H-PYRAZOL-3-YLAMINE, COBALT (II) ION, Methionine aminopeptidase, ... Authors: Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M. Deposit date: 2006-03-23 Release date: 2006-06-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors. Proteins, 66, 2007
2GG9	Novel bacterial methionine aminopeptidase inhibitors Descriptor: COBALT (II) ION, METHYL N-[(2S,3R)-3-AMINO-2-HYDROXY-3-(4-ISOPROPYLPHENYL)PROPANOYL]-D-ALANYL-D-LEUCINATE, Methionine aminopeptidase, ... Authors: Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M. Deposit date: 2006-03-23 Release date: 2006-06-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors. Proteins, 66, 2007
2GG3	Novel bacterial methionine aminopeptidase inhibitors Descriptor: 4-(4-FLUORO-PHENYLAZO)-5-IMINO-5H-PYRAZOL-3-YLAMINE, COBALT (II) ION, Methionine aminopeptidase, ... Authors: Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M. Deposit date: 2006-03-23 Release date: 2006-06-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors. Proteins, 66, 2007
8FJK	Golden Shiner Reovirus Core Polar Vertex Descriptor: Clamp protein VP6, Major inner capsid protein VP3, Microtubule-associated protein VP5, ... Authors: Stevens, A.S, Zhou, Z.H. Deposit date: 2022-12-19 Release date: 2023-03-22 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation. Protein Cell, 14, 2023
7OZH	PMCA-amplified alpha-synuclein fibril polymorph, Multiple System Atrophy patient-derived seeds Descriptor: Alpha-synuclein Authors: Frieg, B, Geraets, J.A, Schroeder, G.F. Deposit date: 2021-06-28 Release date: 2022-07-13 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.02 Å) Cite: alpha-synuclein polymorphism determines oligodendroglial dysfunction To Be Published

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