6QJ7

Difluorophenyl diacylhydrazides: Potent inhibitors of Serum- and Glucocorticoid-inducible Kinase 1 (SGK1)

Summary for 6QJ7

• Entry DOI: 10.2210/pdb6qj7/pdb
• Related: 2GU8
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ~{N}'-[(2~{S})-2-[3,5-bis(fluoranyl)phenyl]-2-oxidanyl-ethanoyl]-2-ethyl-3-methyl-4-oxidanyl-benzohydrazide, ... (4 entities in total)
• Functional Keywords: camp-dependent protein kinase a (pka), transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 43399.32

Authors

Graedler, U. (deposition date: 2019-01-23, release date: 2020-02-12, Last modification date: 2024-01-24)

• Primary citation: Graedler, U.; Difluorophenyl diacylhydrazides: Potent inhibitors of Serum- and Glucocorticoid-inducible Kinase 1 (SGK1); To Be Published,

Experimental method

X-RAY DIFFRACTION (1.69 Å)