8D23
| Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT529 | Descriptor: | 1-{2-[(3-chlorophenyl)methoxy]phenyl}-N-[(pyridin-3-yl)methyl]methanamine, GLYCEROL, N-acetyltransferase Eis | Authors: | Pang, A.H, Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. | Deposit date: | 2022-05-27 | Release date: | 2022-09-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity. Eur.J.Med.Chem., 242, 2022
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5LI7
| Crystal structure of Mycobacterium tuberculosis CYP126A1 in complex with 1-(3-(1H-imidazol-1-yl)propyl)-3-((3s,5s,7s)-adamantan-1-yl)urea | Descriptor: | 1-(1-adamantyl)-3-(3-imidazol-1-ylpropyl)urea, PROTOPORPHYRIN IX CONTAINING FE, Putative cytochrome P450 126 | Authors: | Levy, C, Munro, A.W, Leys, D. | Deposit date: | 2016-07-14 | Release date: | 2016-12-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1. J. Biol. Chem., 292, 2017
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5KWJ
| M.tb Ag85C modified at C209 by amino-ebselen | Descriptor: | Diacylglycerol acyltransferase/mycolyltransferase Ag85C, ~{N}-(4-aminophenyl)-2-selanyl-benzamide | Authors: | Goins, C.M, Ronning, D.R. | Deposit date: | 2016-07-18 | Release date: | 2017-03-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Exploring Covalent Allosteric Inhibition of Antigen 85C from Mycobacterium tuberculosis by Ebselen Derivatives. ACS Infect Dis, 3, 2017
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5KWI
| M.tb Ag85C modified at C209 by adamantyl-ebselen | Descriptor: | Diacylglycerol acyltransferase/mycolyltransferase Ag85C, ~{N}-(1-adamantyl)-2-selanyl-benzamide | Authors: | Goins, C.M, Ronning, D.R. | Deposit date: | 2016-07-18 | Release date: | 2017-03-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Exploring Covalent Allosteric Inhibition of Antigen 85C from Mycobacterium tuberculosis by Ebselen Derivatives. ACS Infect Dis, 3, 2017
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1NFF
| Crystal structure of Rv2002 gene product from Mycobacterium tuberculosis | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative oxidoreductase Rv2002 | Authors: | Yang, J.K, Park, M.S, Waldo, G.S, Suh, S.W, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2002-12-14 | Release date: | 2002-12-30 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis Proc.Natl.Acad.Sci.USA, 100, 2003
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1NFR
| Rv2002 gene product from Mycobacterium tuberculosis | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative oxidoreductase Rv2002 | Authors: | Yang, J.K, Park, M.S, Waldo, G.S, Suh, S.W, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2002-12-16 | Release date: | 2002-12-30 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis Proc.Natl.Acad.Sci.USA, 100, 2003
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4ZY7
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4P2X
| Swapped Dimer of Mycobacterial Adenylyl cyclase Rv1625c: Form 2 | Descriptor: | Adenylate cyclase, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Barathy, D.V, Mattoo, R, Visweswariah, S.S, Suguna, K. | Deposit date: | 2014-03-05 | Release date: | 2014-09-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | New structural forms of a mycobacterial adenylyl cyclase Rv1625c. Iucrj, 1, 2014
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4P2F
| Monomeric form of a single mutant (F363R) of Mycobacterial Adenylyl cyclase Rv1625c | Descriptor: | 1,2-ETHANEDIOL, Adenylate cyclase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Barathy, D.V, Mattoo, R, Visweswariah, S.S, Suguna, K. | Deposit date: | 2014-03-04 | Release date: | 2014-09-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | New structural forms of a mycobacterial adenylyl cyclase Rv1625c. Iucrj, 1, 2014
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4P2M
| Swapped Dimer of Mycobacterial Adenylyl cyclase Rv1625c: Form 1 | Descriptor: | Adenylate cyclase, DI(HYDROXYETHYL)ETHER, SULFATE ION | Authors: | Barathy, D.V, Mattoo, R, Visweswariah, S.S, Suguna, K. | Deposit date: | 2014-03-04 | Release date: | 2014-09-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | New structural forms of a mycobacterial adenylyl cyclase Rv1625c. Iucrj, 1, 2014
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3D98
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3VOM
| Structure of a putative phosphoserine aminotransferase from mycobacterium tuberculosis | Descriptor: | GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, Putative phosphoserine aminotransferase, ... | Authors: | Coulibaly, F, Lassalle, E, Baker, H.M, Baker, E.N. | Deposit date: | 2012-01-30 | Release date: | 2012-02-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis. Acta Crystallogr.,Sect.D, 68, 2012
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5MPV
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4QDT
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4QDO
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4QDU
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8OFW
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6DCD
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3LF0
| Crystal structure of the ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Nitrogen regulatory protein P-II | Authors: | Shetty, N.D, Palaninathan, S.K, Reddy, M.C.M, Owen, J.L, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2010-01-15 | Release date: | 2010-07-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein. Protein Sci., 19, 2010
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5WS9
| Pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate, ATP and allosteric activator AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Zhong, W, Cai, Q, El Sahili, A, Lescar, J, Dedon, P.C. | Deposit date: | 2016-12-06 | Release date: | 2017-11-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis. Nat Commun, 8, 2017
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5WSC
| Crystal of pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate, soaked with allosteric activators AMP and Glucose 6-Phosphate | Descriptor: | 6-O-phosphono-alpha-D-glucopyranose, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ... | Authors: | Zhong, W, Cai, Q, El Sahili, A, Lescar, J, Dedon, P.C. | Deposit date: | 2016-12-06 | Release date: | 2017-11-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis. Nat Commun, 8, 2017
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2BMX
| Mycobacterium tuberculosis AhpC | Descriptor: | ALKYL HYDROPEROXIDASE C | Authors: | Guimaraes, B.G, Alzari, P.M. | Deposit date: | 2005-03-16 | Release date: | 2005-05-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure and Mechanism of the Alkyl Hydroperoxidase Ahpc, a Key Element of the Mycobacterium Tuberculosis Defense System Against Oxidative Stress. J.Biol.Chem., 280, 2005
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7ZTA
| Structure of an Escherichia coli 70S ribosome stalled by Tetracenomycin X during translation of an MAAAPQK(C) peptide | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Leroy, E.C, Perry, T.N, Renault, T.T, Innis, C.A. | Deposit date: | 2022-05-09 | Release date: | 2023-04-12 | Last modified: | 2024-09-25 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Tetracenomycin X sequesters peptidyl-tRNA during translation of QK motifs. Nat.Chem.Biol., 19, 2023
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3LRM
| Structure of alfa-galactosidase from Saccharomyces cerevisiae with raffinose | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Fernandez-Leiro, R, Pereira-Rodriguez, A, Cerdan, M.E, Becerra, M, Sanz-Aparicio, J. | Deposit date: | 2010-02-11 | Release date: | 2010-06-30 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural analysis of Saccharomyces cerevisiae alpha-galactosidase and its complexes with natural substrates reveals new insights into substrate specificity of GH27 glycosidases. J.Biol.Chem., 285, 2010
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2BVC
| Crystal structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition state mimic | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, GLUTAMINE SYNTHETASE 1, ... | Authors: | Krajewski, W.W, Jones, T.A, Mowbray, S.L. | Deposit date: | 2005-06-23 | Release date: | 2005-07-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of Mycobacterium Tuberculosis Glutamine Synthetase in Complex with a Transition-State Mimic Provides Functional Insights. Proc.Natl.Acad.Sci.USA, 102, 2005
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