4W1X

Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with 1-(4-(4-(3-chlorobenzoyl)piperazin-1-yl)phenyl)ethanone

Summary for 4W1X

Entry DOI	10.2210/pdb4w1x/pdb
Related	4W1V 4W1W
Descriptor	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	inhibitor complex transaminase plp, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mycobacterium tuberculosis
Cellular location	Cytoplasm : P9WQ80
Total number of polymer chains	2
Total formula weight	98545.29
Authors	Finzel, B.C.,Dai, R. (deposition date: 2014-08-13, release date: 2015-02-04, Last modification date: 2023-12-27)
Primary citation	Park, S.W.,Casalena, D.E.,Wilson, D.J.,Dai, R.,Nag, P.P.,Liu, F.,Boyce, J.P.,Bittker, J.A.,Schreiber, S.L.,Finzel, B.C.,Schnappinger, D.,Aldrich, C.C. Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis. Chem.Biol., 22:76-86, 2015 Cited by PubMed: 25556942 DOI: 10.1016/j.chembiol.2014.11.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation