PDB: 335 resultsInfo pagesStatus searchChemie searchBIRD

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8IGR	Cryo-EM structure of CII-dependent transcription activation complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y. Deposit date: 2023-02-21 Release date: 2023-05-17 Last modified: 2023-08-16 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis of lambda CII-dependent transcription activation. Structure, 31, 2023
8IGS	Cryo-EM structure of RNAP-promoter open complex at lambda promoter PRE Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y. Deposit date: 2023-02-21 Release date: 2023-05-17 Last modified: 2023-08-16 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural basis of lambda CII-dependent transcription activation. Structure, 31, 2023
6CUU	Thermus thermophiles RNA polymerase in complex with promoter DNA and antibiotic Kanglemycin A Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*CP*TP*CP*TP*GP*AP*TP*GP*CP*A)-3'), DNA (5'-D(P*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Molodtsov, V, Murakami, K.S. Deposit date: 2018-03-26 Release date: 2018-07-25 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.994 Å) Cite: Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. Mol. Cell, 72, 2018
6DCF	Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and bound to kanglemycin A Descriptor: 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... Authors: Lilic, M, Darst, S.A, Campbell, E.A. Deposit date: 2018-05-06 Release date: 2018-09-05 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.45 Å) Cite: Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
1RP3	Cocrystal structure of the flagellar sigma/anti-sigma complex, Sigma-28/FlgM Descriptor: RNA polymerase sigma factor SIGMA-28 (FliA), anti sigma factor FlgM Authors: Sorenson, M.K, Ray, S.S, Darst, S.A. Deposit date: 2003-12-02 Release date: 2004-04-06 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of the Flagellar Sigma/Anti-Sigma Complex Sigma(28)/FlgM Reveals an Intact Sigma Factor in an Inactive Conformation Mol.Cell, 14, 2004
1RIO	Structure of bacteriophage lambda cI-NTD in complex with sigma-region4 of Thermus aquaticus bound to DNA Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 27-MER, CALCIUM ION, ... Authors: Jain, D, Nickels, B.E, Sun, L, Hochschild, A, Darst, S.A. Deposit date: 2003-11-17 Release date: 2004-01-27 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of a ternary transcription activation complex. Mol.Cell, 13, 2004
4ZH3	Crystal structure of Escherichia coli RNA polymerase in complex with CBRH16-Br Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Feng, Y, Ebright, R.H. Deposit date: 2015-04-24 Release date: 2015-08-05 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (4.082 Å) Cite: Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles. Structure, 23, 2015
5VO8	X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*CP*TP*GP*AP*TP*GP*CP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Murakami, K.S, Shin, Y, Turnbough Jr, C.L, Molodtsov, V. Deposit date: 2017-05-02 Release date: 2017-05-24 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.3 Å) Cite: X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5VT0	Escherichia coli 6S RNA derivative in complex with Escherichia coli RNA polymerase sigma70-holoenzyme Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Chen, J, Darst, S.A. Deposit date: 2017-05-15 Release date: 2017-11-01 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.78 Å) Cite: 6S RNA Mimics B-Form DNA to Regulate Escherichia coli RNA Polymerase. Mol. Cell, 68, 2017
5VI5	Structure of Mycobacterium smegmatis transcription initiation complex with a full transcription bubble Descriptor: 1,2-ETHANEDIOL, DNA (44-MER), DNA (49-MER), ... Authors: Darst, S.A, Campbell, E.A, Lilic, M. Deposit date: 2017-04-14 Release date: 2017-07-26 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.196 Å) Cite: Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures. Nat Commun, 8, 2017
8R3M	Mycobacterium smegnatis RNA polymerase transcription initiation complex with SigmaA, RbpA, HelD N-terminal, CO and PCh loop domain, and an upstream-fork promoter fragment; State III conformation Descriptor: DNA 22-MER, DNA 31-MER, DNA-directed RNA polymerase subunit alpha, ... Authors: Koval, T, Krasny, L, Dohnalek, J, Kouba, T. Deposit date: 2023-11-09 Release date: 2024-10-02 Method: ELECTRON MICROSCOPY (3.49 Å) Cite: Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
8R6R	Mycobacterium smegnatis RNA polymerase RP2-like transcription initiation complex with SigmaA, RbpA and open promoter DNA Descriptor: DNA 50-MER, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Koval, T, Krasny, L, Dohnalek, J, Kouba, T. Deposit date: 2023-11-22 Release date: 2024-10-02 Method: ELECTRON MICROSCOPY (3.89 Å) Cite: Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
8R2M	Mycobacterium smegnatis RNA polymerase transcription initiation complex with SigmaA, RbpA, HelD N-terminal domain and an upstream-fork promoter fragment; State III conformation Descriptor: DNA 22-MER, DNA 31-MER, DNA-directed RNA polymerase subunit alpha, ... Authors: Koval, T, Krasny, L, Dohnalek, J, Kouba, T. Deposit date: 2023-11-06 Release date: 2024-10-02 Method: ELECTRON MICROSCOPY (3.44 Å) Cite: Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
8R6P	Mycobacterium smegnatis RNA polymerase RP2-like transcription initiation complex with SigmaA, RbpA, HelD N-terminal domain and open promoter DNA Descriptor: DNA 50-MER, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Koval, T, Krasny, L, Dohnalek, J, Kouba, T. Deposit date: 2023-11-22 Release date: 2024-10-02 Method: ELECTRON MICROSCOPY (3.16 Å) Cite: Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
4ZH4	Crystal structure of Escherichia coli RNA polymerase in complex with CBRP18 Descriptor: 5-(4-fluorophenyl)-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-pyrazole, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Feng, Y, Ebright, R.H. Deposit date: 2015-04-24 Release date: 2015-08-05 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.993 Å) Cite: Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles. Structure, 23, 2015
5VSW	X-ray crystal structure of Escherichia coli RNA polymerase and DksA/ppGpp complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Murakami, K.S, Molodtsov, V. Deposit date: 2017-05-12 Release date: 2017-06-14 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (4.295 Å) Cite: Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA. Mol. Cell, 69, 2018
7Q59	Cryo-EM structure of Mycobacterium tuberculosis RNA polymerase holoenzyme dimer comprising sigma factor SigB Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Brodolin, K. Deposit date: 2021-11-03 Release date: 2022-11-16 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (4.36 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization Nat Commun, 14, 2023
5IPL	SigmaS-transcription initiation complex with 4-nt nascent RNA Descriptor: DIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Liu, B, Zuo, Y, Steitz, T.A. Deposit date: 2016-03-09 Release date: 2016-03-30 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
5IPM	SigmaS-transcription initiation complex with 4-nt nascent RNA Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Liu, B, Zuo, Y, Steitz, T.A. Deposit date: 2016-03-09 Release date: 2016-03-30 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (4.2 Å) Cite: Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
7RDQ	Cryo-EM structure of Thermus thermophilus reiterative transcription complex with 11nt oligo-G RNA Descriptor: DNA (31-MER) nontemplate strand, DNA (31-MER) template strand, DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, Y, Ebright, R.H. Deposit date: 2021-07-10 Release date: 2022-02-02 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural and mechanistic basis of reiterative transcription initiation. Proc.Natl.Acad.Sci.USA, 119, 2022
5IPN	SigmaS-transcription initiation complex with 4-nt nascent RNA Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Liu, B, Zuo, Y, Steitz, T.A. Deposit date: 2016-03-09 Release date: 2016-03-30 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (4.61 Å) Cite: Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
8Q3I	Mycobacterium smegmatis RNA polymerase in complex with HelD, SigA and RbpA in State I Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Koval, T, Krasny, L, Dohnalek, J, Kouba, T. Deposit date: 2023-08-04 Release date: 2024-08-14 Method: ELECTRON MICROSCOPY (3.11 Å) Cite: Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
5I2D	Crystal structure of T. thermophilus TTHB099 class II transcription activation complex: TAP-RPo Descriptor: DNA (72-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Feng, Y, Zhang, Y, Ebright, R.H. Deposit date: 2016-02-08 Release date: 2016-06-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (4.405 Å) Cite: Structural basis of transcription activation. Science, 352, 2016
8QTI	Mycobacterium smegnatis RNAP open promoter complex with SigmaA and RbpA Descriptor: DNA 50-mer non-template strand, DNA 50-mer template strand, DNA-directed RNA polymerase subunit alpha, ... Authors: Koval, T, Krasny, L, Dohnalek, J, Kouba, T. Deposit date: 2023-10-12 Release date: 2024-10-02 Method: ELECTRON MICROSCOPY (3.09 Å) Cite: Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
8QN8	Mycobacterium smegmatis RNA polymerase in complex with HelD, SigA and RbpA in State II Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Koval, T, Krasny, L, Dohnalek, J, Kouba, T. Deposit date: 2023-09-25 Release date: 2024-10-02 Method: ELECTRON MICROSCOPY (3.14 Å) Cite: Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published

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