3E2K
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![BU of 3e2k by Molmil](/molmil-images/mine/3e2k) | Crystal Structure of the KPC-2 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) | Descriptor: | Beta-lactamase inhibitory protein, Carbapenemase | Authors: | Hanes, M.S, Jude, K.M, Berger, J.M, Bonomo, R.A, Handel, T.M. | Deposit date: | 2008-08-05 | Release date: | 2009-08-04 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and biochemical characterization of the interaction between KPC-2 beta-lactamase and beta-lactamase inhibitor protein Biochemistry, 48, 2009
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1PIO
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![BU of 1pio by Molmil](/molmil-images/mine/1pio) | |
3D4F
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![BU of 3d4f by Molmil](/molmil-images/mine/3d4f) | SHV-1 beta-lactamase complex with LN1-255 | Descriptor: | (3R)-4-{[(3,4-dihydroxyphenyl)acetyl]oxy}-N-(2-formylindolizin-3-yl)-3-sulfino-D-valine, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | Authors: | Pattanaik, P, Bethel, C.R, Hujer, A.M, Bonomo, R.A, Buynak, J.D, van den Akker, F. | Deposit date: | 2008-05-14 | Release date: | 2009-02-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Strategic Design of an Effective {beta}-Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONE J.Biol.Chem., 284, 2009
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1PZO
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![BU of 1pzo by Molmil](/molmil-images/mine/1pzo) | TEM-1 Beta-Lactamase in Complex with a Novel, Core-Disrupting, Allosteric Inhibitor | Descriptor: | Beta-lactamase TEM, N,N-BIS(4-CHLOROBENZYL)-1H-1,2,3,4-TETRAAZOL-5-AMINE | Authors: | Horn, J.R, Shoichet, B.K. | Deposit date: | 2003-07-14 | Release date: | 2004-03-09 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Allosteric inhibition through core disruption. J.Mol.Biol., 336, 2004
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1PZP
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![BU of 1pzp by Molmil](/molmil-images/mine/1pzp) | |
3CMZ
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![BU of 3cmz by Molmil](/molmil-images/mine/3cmz) | TEM-1 Class-A beta-lactamase L201P mutant apo structure | Descriptor: | Beta-lactamase TEM, PHOSPHATE ION | Authors: | Marciano, D.C, Wang, X, Wang, J, Chen, Y, Thomas, V.L, Shoichet, B.K, Palzkill, T. | Deposit date: | 2008-03-24 | Release date: | 2008-11-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Genetic and structural characterization of an L201P global suppressor substitution in TEM-1 beta-lactamase J.Mol.Biol., 384, 2008
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1O7E
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1ONG
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![BU of 1ong by Molmil](/molmil-images/mine/1ong) | SHV-1 beta-lactamase with a penem inhibitor | Descriptor: | 7-(5,6-DIHYDRO-8H-IMIDAZO[2,1-C][1,4]OXAZIN-2-YL)-6-FORMYL-2,7-DIHYDRO- [1,4]THIAZEPINE-3-CARBOXYLIC ACID, BETA-LACTAMASE SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | Authors: | Nukaga, M, Mayama, K, Bonomo, R.A, Knox, J.R. | Deposit date: | 2003-02-27 | Release date: | 2003-12-09 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Inhibition of Class A and Class C Beta-Lactamases by Penems: Crystallographic Structures of a Novel 1,4-Thiazepine Intermediate Biochemistry, 42, 2003
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3DWZ
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![BU of 3dwz by Molmil](/molmil-images/mine/3dwz) | Meropenem Covalent Adduct with TB Beta-lactamase | Descriptor: | (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase, PHOSPHATE ION | Authors: | Tremblay, L.W, Hugonnet, J.E, Blanchard, J.S. | Deposit date: | 2008-07-23 | Release date: | 2009-03-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis Science, 323, 2009
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3DTM
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![BU of 3dtm by Molmil](/molmil-images/mine/3dtm) | |
3DW0
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![BU of 3dw0 by Molmil](/molmil-images/mine/3dw0) | Crystal structure of the class A carbapenemase KPC-2 at 1.6 angstrom resolution | Descriptor: | Class A carbapenemase KPC-2 | Authors: | Petrella, S, Ziental-Gelus, N, Mayer, C, Jarlier, V, Sougakoff, W. | Deposit date: | 2008-07-21 | Release date: | 2008-07-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. Antimicrob.Agents Chemother., 52, 2008
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1N4O
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1N9B
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![BU of 1n9b by Molmil](/molmil-images/mine/1n9b) | Ultrahigh resolution structure of a class A beta-lactamase: On the mechanism and specificity of the extended-spectrum SHV-2 enzyme | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BETA-LACTAMASE SHV-2, ... | Authors: | Nukaga, M, Mayama, K, Hujer, A.M, Bonomo, R.A, Knox, J.R. | Deposit date: | 2002-11-22 | Release date: | 2003-04-08 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (0.9 Å) | Cite: | Ultrahigh resolution structure of a class A beta-lactamase: On the mechanism and specificity of the extended-spectrum SHV-2 enzyme J.Mol.Biol., 328, 2003
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1NYM
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![BU of 1nym by Molmil](/molmil-images/mine/1nym) | Crystal Structure of the complex between M182T mutant of TEM-1 and a boronic acid inhibitor (CXB) | Descriptor: | Beta-lactamase TEM, PHOSPHATE ION, POTASSIUM ION, ... | Authors: | Wang, X, Minasov, G, Blazquez, J, Caselli, E, Prati, F, Shoichet, B.K. | Deposit date: | 2003-02-12 | Release date: | 2003-08-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Recognition and resistance in TEM beta-lactamase Biochemistry, 42, 2003
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3G34
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![BU of 3g34 by Molmil](/molmil-images/mine/3g34) | CTX-M-9 class A beta-lactamase complexed with compound 11 (1CE) | Descriptor: | 3-(1H-tetrazol-5-ylmethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one, Beta-lactamase CTX-M-9a, DIMETHYL SULFOXIDE, ... | Authors: | Chen, Y, Shoichet, B.K. | Deposit date: | 2009-02-01 | Release date: | 2009-03-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Molecular docking and ligand specificity in fragment-based inhibitor discovery Nat.Chem.Biol., 5, 2009
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1NYY
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![BU of 1nyy by Molmil](/molmil-images/mine/1nyy) | Crystal Structure of the complex between M182T mutant of TEM-1 and a boronic acid inhibitor (105) | Descriptor: | Beta-lactamase TEM, N-[5-METHYL-3-O-TOLYL-ISOXAZOLE-4-CARBOXYLIC ACID AMIDE] BORONIC ACID | Authors: | Wang, X, Minasov, G, Blazquez, J, Caselli, E, Prati, F, Shoichet, B.K. | Deposit date: | 2003-02-14 | Release date: | 2003-08-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Recognition and resistance in TEM beta-lactamase Biochemistry, 42, 2003
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1NY0
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![BU of 1ny0 by Molmil](/molmil-images/mine/1ny0) | Crystal Structure of the complex between M182T mutant of TEM-1 and a boronic acid inhibitor (NBF) | Descriptor: | Beta-lactamase TEM, PHOSPHATE ION, POTASSIUM ION, ... | Authors: | Wang, X, Minasov, G, Blazquez, J, Caselli, E, Prati, F, Shoichet, B.K. | Deposit date: | 2003-02-11 | Release date: | 2003-08-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Recognition and Resistance in TEM beta-lactamase Biochemistry, 42, 2003
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1OME
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![BU of 1ome by Molmil](/molmil-images/mine/1ome) | CRYSTAL STRUCTURE OF THE OMEGA LOOP DELETION MUTANT (RESIDUES 163-178 DELETED) OF BETA-LACTAMASE FROM STAPHYLOCOCCUS AUREUS PC1 | Descriptor: | BETA-LACTAMASE, CHLORIDE ION | Authors: | Banerjee, S, Pieper, U, Herzberg, O. | Deposit date: | 1998-02-09 | Release date: | 1998-05-27 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Role of the omega-loop in the activity, substrate specificity, and structure of class A beta-lactamase. Biochemistry, 37, 1998
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3G2Z
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![BU of 3g2z by Molmil](/molmil-images/mine/3g2z) | |
3G35
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3G31
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![BU of 3g31 by Molmil](/molmil-images/mine/3g31) | CTX-M-9 class A beta-lactamase complexed with compound 4 (GF1) | Descriptor: | (2S)-2-[(3aR,4R,7S,7aS)-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl]propanoic acid, Beta-lactamase CTX-M-9a, DIMETHYL SULFOXIDE, ... | Authors: | Chen, Y, Shoichet, B.K. | Deposit date: | 2009-02-01 | Release date: | 2009-03-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Molecular docking and ligand specificity in fragment-based inhibitor discovery Nat.Chem.Biol., 5, 2009
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3G30
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![BU of 3g30 by Molmil](/molmil-images/mine/3g30) | |
3G32
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![BU of 3g32 by Molmil](/molmil-images/mine/3g32) | CTX-M-9 class A beta-lactamase complexed with compound 6 (3G3) | Descriptor: | 2-[2-(1H-tetrazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione, Beta-lactamase CTX-M-9a, DIMETHYL SULFOXIDE, ... | Authors: | Chen, Y, Shoichet, B.K. | Deposit date: | 2009-02-01 | Release date: | 2009-03-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Molecular docking and ligand specificity in fragment-based inhibitor discovery Nat.Chem.Biol., 5, 2009
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3G2Y
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![BU of 3g2y by Molmil](/molmil-images/mine/3g2y) | CTX-M-9 class A beta-lactamase complexed with compound 1 (GF4) | Descriptor: | 4-ethyl-5-methyl-2-(1H-tetrazol-5-yl)-1,2-dihydro-3H-pyrazol-3-one, Beta-lactamase CTX-M-9a, DIMETHYL SULFOXIDE | Authors: | Chen, Y, Shoichet, B.K. | Deposit date: | 2009-02-01 | Release date: | 2009-03-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Molecular docking and ligand specificity in fragment-based inhibitor discovery Nat.Chem.Biol., 5, 2009
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1NXY
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![BU of 1nxy by Molmil](/molmil-images/mine/1nxy) | Crystal Structure of the complex between M182T mutant of TEM-1 and a boronic acid inhibitor (SM2) | Descriptor: | (1R)-1-(2-THIENYLACETYLAMINO)-1-(3-CARBOXYPHENYL)METHYLBORONIC ACID, Beta-lactamase TEM, POTASSIUM ION | Authors: | Wang, X, Minasov, G, Blazquez, J, Caselli, E, Prati, F, Shoichet, B.K. | Deposit date: | 2003-02-11 | Release date: | 2003-08-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Recognition and Resistance in TEM beta-lactamase Biochemistry, 42, 2003
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