PDB: 8717 resultsInfo pagesStatus searchChemie searchBIRD

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3H4C	Structure of the C-terminal Domain of Transcription Factor IIB from Trypanosoma brucei Descriptor: 1,2-ETHANEDIOL, Transcription factor TFIIB-like Authors: Syed Ibrahim, B, Kanneganti, N, Rieckhof, G.E, Das, A, Laurents, D.V, Palenchar, J.B, Bellofatto, V, Wah, D.A. Deposit date: 2009-04-18 Release date: 2009-08-11 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of the C-terminal domain of transcription factor IIB from Trypanosoma brucei. Proc.Natl.Acad.Sci.USA, 106, 2009
7NHT	Akirin2 bound human proteasome Descriptor: Akirin-2, POTASSIUM ION, Proteasome subunit alpha type-1, ... Authors: Singh, K, Brunner, H, Grishkovskaya, I, de Almeida, M, Hinterndorfer, M, Zuber, J, Haselbach, D. Deposit date: 2021-02-11 Release date: 2021-09-01 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: AKIRIN2 controls the nuclear import of proteasomes in vertebrates. Nature, 599, 2021
6K08	Crystal structure of REV7(R124A/A135D) in complex with a Shieldin3 fragment Descriptor: Mitotic spindle assembly checkpoint protein MAD2B, SULFATE ION, Shieldin complex subunit 3 Authors: Zhang, F, Dai, Y. Deposit date: 2019-05-05 Release date: 2019-12-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.312 Å) Cite: Structural basis for shieldin complex subunit 3-mediated recruitment of the checkpoint protein REV7 during DNA double-strand break repair. J.Biol.Chem., 295, 2020
3QWP	Crystal structure of SET and MYND domain containing 3; Zinc finger MYND domain-containing protein 1 Descriptor: GLYCEROL, S-ADENOSYLMETHIONINE, SET and MYND domain-containing protein 3, ... Authors: Dong, A, Dombrovski, L, Li, Y, Wernimont, A, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) Deposit date: 2011-02-28 Release date: 2011-04-06 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.53 Å) Cite: The Crystal Structure of human Histone-lysine N-methyltransferase SMYD3 To be Published
7Z8B	Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation Descriptor: Cullin-7, E3 ubiquitin-protein ligase RBX1, F-box/WD repeat-containing protein 8, ... Authors: Hopf, L.V.M, Schulman, B.A. Deposit date: 2022-03-17 Release date: 2022-08-24 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Structure of CRL7 FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation. Nat.Struct.Mol.Biol., 29, 2022
3AJI	Structure of Gankyrin-S6ATPase photo-cross-linked site-specifically, and incoporated by genetic code expansion Descriptor: 26S proteasome non-ATPase regulatory subunit 10, Proteasome (Prosome, macropain) 26S subunit, ... Authors: Sato, S, Mimasu, S, Sato, A, Hino, N, Sakamoto, K, Umehara, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2010-06-07 Release date: 2010-12-22 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystallographic study of a site-specifically cross-linked protein complex with a genetically incorporated photoreactive amino acid Biochemistry, 50, 2011
4QP1	Crystal structure of ERK2 in complex with N-cyclohexyl-9H-purin-6-amine Descriptor: IMIDAZOLE, Mitogen-activated protein kinase 1, N-BENZYL-9H-PURIN-6-AMINE Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2015-12-16 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QP9	Crystal Structure of ERK2 in complex with 7-(1-propyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine Descriptor: 7-(1-propyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine, Mitogen-activated protein kinase 1 Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.001 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
3PDN	Crystal structure of SmyD3 in complex with methyltransferase inhibitor sinefungin Descriptor: GLYCEROL, MAGNESIUM ION, SET and MYND domain-containing protein 3, ... Authors: Sirinupong, N, Brunzelle, J, Yang, Z. Deposit date: 2010-10-23 Release date: 2010-11-17 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural Insights into the Autoinhibition and Posttranslational Activation of Histone Methyltransferase SmyD3. J.Mol.Biol., 406, 2011
4QP7	Crystal Structure of ERK2 in complex with 2-(1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine Descriptor: 2-(1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine, Mitogen-activated protein kinase 1 Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.249 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QP4	Crystal Structure of ERK2 in complex with N-cyclohexyl-9H-purin-6-amine Descriptor: Mitogen-activated protein kinase 1, N-cyclohexyl-9H-purin-6-amine Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QPA	Crystal Structure of ERK2 in complex with 7-(1-benzyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine Descriptor: 7-(1-benzyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine, Mitogen-activated protein kinase 1 Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2015-12-16 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QP3	Crystal Structure of ERK2 in complex with (S)-2-((9H-purin-6-yl)amino)-3-phenylpropan-1-ol Descriptor: (2S)-3-phenyl-2-(9H-purin-6-ylamino)propan-1-ol, Mitogen-activated protein kinase 1 Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2015-12-16 Method: X-RAY DIFFRACTION (2.599 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QP6	Crystal Structure of ERK2 in complex with 5H-pyrrolo[2,3-b]pyrazine Descriptor: 5H-pyrrolo[2,3-b]pyrazine, IMIDAZOLE, Mitogen-activated protein kinase 1 Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2015-12-16 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QP8	Crystal Structure of ERK2 in complex with 2-(1H-pyrazol-4-yl)-7-(pyridin-3-yl)-5H-pyrrolo[2,3-b]pyrazine Descriptor: 2-(1H-pyrazol-4-yl)-7-(pyridin-3-yl)-5H-pyrrolo[2,3-b]pyrazine, Mitogen-activated protein kinase 1 Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.446 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QP2	Crystal Structure of ERKs in complex with 5-chlorobenzo[d]oxazol-2-amine Descriptor: 5-chloro-1,3-benzoxazol-2-amine, IMIDAZOLE, Mitogen-activated protein kinase 1 Authors: Yin, J, Wang, W. Deposit date: 2014-06-22 Release date: 2015-09-23 Last modified: 2015-12-16 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QYY	Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State Descriptor: (3R)-1-{2-[4-(4-acetylphenyl)piperazin-1-yl]-2-oxoethyl}-N-(3-chloro-4-hydroxyphenyl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION Authors: Deng, Y, Shipps, G.W, Cooper, A, English, J.M, Annis, D.A, Carr, D, Nan, Y, Wang, T, Zhu, Y.H, Chuang, C, Dayananth, P, Hruza, A.W, Xiao, L, Jin, W, Kirschmeier, P, Windsor, W.T, Samatar, A.A. Deposit date: 2014-07-26 Release date: 2014-11-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase. J.Med.Chem., 57, 2014
1Q21	CRYSTAL STRUCTURES AT 2.2 ANGSTROMS RESOLUTION OF THE CATALYTIC DOMAINS OF NORMAL RAS PROTEIN AND AN ONCOGENIC MUTANT COMPLEXED WITH GSP Descriptor: C-H-RAS P21 PROTEIN CATALYTIC DOMAIN, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION Authors: Kim, S.-H. Deposit date: 1991-09-25 Release date: 1992-07-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP. J.Mol.Biol., 217, 1991
1QYM	X-ray structure of human gankyrin Descriptor: 26S proteasome non-ATPase regulatory subunit 10 Authors: Manjasetty, B.A, Quedenau, C, Sievert, V, Buessow, K, Niesen, F, Delbrueck, H, Heinemann, U. Deposit date: 2003-09-11 Release date: 2003-11-18 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.8 Å) Cite: X-ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma. Proteins, 55, 2004
8TU6	CryoEM structure of PI3Kalpha Descriptor: Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Authors: Valverde, R, Shi, H, Holliday, M. Deposit date: 2023-08-15 Release date: 2023-11-15 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia. Cancer Discov, 14, 2024
8F93	WDR5 covalently modified at Y228 by (R)-2-SF Descriptor: 3-ethynyl-5-{[(3R)-4-{1-[(2-methoxyphenyl)methyl]-1H-benzimidazole-5-carbonyl}-3-methylpiperazin-1-yl]methyl}benzene-1-sulfonyl fluoride, CHLORIDE ION, GLYCEROL, ... Authors: Taunton, J, Craven, G.B, Chen, Y. Deposit date: 2022-11-23 Release date: 2023-05-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes. Nat.Chem., 15, 2023
4ERK	THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/OLOMOUCINE Descriptor: EXTRACELLULAR REGULATED KINASE 2, OLOMOUCINE, SULFATE ION Authors: Wang, Z, Canagarajah, B, Boehm, J.C, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J. Deposit date: 1998-07-09 Release date: 1999-07-22 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural basis of inhibitor selectivity in MAP kinases. Structure, 6, 1998
7T91	Crystal structure of Zinc finger motif 1 and 2 of GLI1 DNA binding region Descriptor: Isoform 2 of Zinc finger protein GLI1, ZINC ION Authors: Wu, M, Zhang, S, Augelli-Szanfran, C.E, Boohaker, R.J. Deposit date: 2021-12-17 Release date: 2022-12-21 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal structure of Zinc finger motif 1 and 2 of GLI1 DNA binding region To Be Published
6Q7K	ERK2 mini-fragment binding Descriptor: 1H-imidazol-2-amine, Mitogen-activated protein kinase 1, SULFATE ION Authors: O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. Deposit date: 2018-12-13 Release date: 2019-03-27 Last modified: 2019-05-22 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
2BZE	NMR Structure of human RTF1 PLUS3 domain. Descriptor: KIAA0252 PROTEIN Authors: Truffault, V, Diercks, T, Ab, E, De Jong, R.N, Daniels, M.A, Kaptein, R, Folkers, G.E, Structural Proteomics in Europe (SPINE) Deposit date: 2005-08-16 Release date: 2007-01-03 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Structure and DNA Binding of the Human Rtf1 Plus3 Domain. Structure, 16, 2008

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