PDB: 72678 resultsInfo pagesStatus searchChemie searchBIRD

---

6WQT	Xanthomonas citri Methionyl-tRNA synthetase in complex with REP3123 Descriptor: 5-[(3-{[(4R)-6,8-dibromo-3,4-dihydro-2H-1-benzopyran-4-yl]amino}propyl)amino]thieno[3,2-b]pyridin-7(6H)-one, Methionine--tRNA ligase, ZINC ION Authors: Mercaldi, G.F, Benedetti, C.E. Deposit date: 2020-04-29 Release date: 2021-04-21 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Molecular basis for diaryldiamine selectivity and competition with tRNA in a type 2 methionyl-tRNA synthetase from a Gram-negative bacterium. J.Biol.Chem., 296, 2021
6X94	An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli Descriptor: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Zambaldo, C, Koh, M, Nasertorabi, F, Han, G.W, Chatterjee, A, Stevens, R.C, Schultz, P.G. Deposit date: 2020-06-02 Release date: 2020-11-04 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.45 Å) Cite: An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli. Bioorg.Med.Chem., 28, 2020
3KT6	Crystal structure of S. cerevisiae tryptophanyl-tRNA synthetase in complex with Trp Descriptor: SULFATE ION, TRYPTOPHAN, Tryptophanyl-tRNA synthetase, ... Authors: Zhou, M, Dong, X, Zhong, C, Shen, N, Ding, J. Deposit date: 2009-11-24 Release date: 2010-02-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design Nucleic Acids Res., 38, 2010
3KT0	Crystal structure of S. cerevisiae tryptophanyl-tRNA synthetase Descriptor: (2S)-1-{[(2S)-3-(2-methoxyethoxy)-2-methylpropyl]oxy}propan-2-amine, Tryptophanyl-tRNA synthetase, cytoplasmic Authors: Zhou, M, Dong, X, Zhong, C, Shen, N, Ding, J. Deposit date: 2009-11-24 Release date: 2010-02-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design Nucleic Acids Res., 38, 2010
3KT8	Crystal structure of S. cerevisiae tryptophanyl-tRNA synthetase in complex with L-tryptophanamide Descriptor: L-TRYPTOPHANAMIDE, SULFATE ION, Tryptophanyl-tRNA synthetase, ... Authors: Zhou, M, Dong, X, Zhong, C, Shen, N, Ding, J. Deposit date: 2009-11-24 Release date: 2010-02-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design Nucleic Acids Res., 38, 2010
1YSV	Solution structure of the central region of the human GluR-B R/G pre-mRNA Descriptor: 27-MER Authors: Stefl, R, Allain, F.H. Deposit date: 2005-02-09 Release date: 2005-07-19 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: A novel RNA pentaloop fold involved in targeting ADAR2. Rna, 11, 2005
3KT3	Crystal structure of S. cerevisiae tryptophanyl-tRNA synthetase in complex with TrpAMP Descriptor: SULFATE ION, TRYPTOPHANYL-5'AMP, Tryptophanyl-tRNA synthetase, ... Authors: Zhou, M, Dong, X, Zhong, C, Shen, N, Ding, J. Deposit date: 2009-11-24 Release date: 2010-02-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design Nucleic Acids Res., 38, 2010
6SPR	Structure of the Escherichia coli methionyl-tRNA synthetase variant VI298 complexed with beta-methionine Descriptor: (3R)-3-amino-5-(methylsulfanyl)pentanoic acid, CITRIC ACID, GLYCEROL, ... Authors: Nigro, G, Schmitt, E, Mechulam, Y. Deposit date: 2019-09-02 Release date: 2020-01-01 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Use of beta3-methionine as an amino acid substrate of Escherichia coli methionyl-tRNA synthetase. J.Struct.Biol., 209, 2020
3QE4	An evolved aminoacyl-tRNA Synthetase with atypical polysubstrate specificity Descriptor: 4-cyano-L-phenylalanine, Tyrosyl-tRNA synthetase Authors: Young, D.D, Young, T.S, Jahnz, M, Ahmad, I, Spraggon, G, Schultz, P.G. Deposit date: 2011-01-19 Release date: 2011-02-16 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: An Evolved Aminoacyl-tRNA Synthetase with Atypical Polysubstrate Specificity . Biochemistry, 50, 2011
2YXN	Structual basis of azido-tyrosine recognition by engineered bacterial Tyrosyl-tRNA synthetase Descriptor: 3-AZIDO-L-TYROSINE, Tyrosyl-tRNA synthetase Authors: Oki, K, Kobayashi, T, Sakamoto, K, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-04-26 Release date: 2008-04-29 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Functional replacement of the endogenous tyrosyl-tRNA synthetase-tRNATyr pair by the archaeal tyrosine pair in Escherichia coli for genetic code expansion Nucleic Acids Res., 38, 2010
7K16	Tamana Bat Virus xrRNA1 Descriptor: MAGNESIUM ION, RNA (51-MER), SODIUM ION Authors: Jones, R.A, Kieft, J.S. Deposit date: 2020-09-07 Release date: 2020-10-14 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Different tertiary interactions create the same important 3D features in a distinct flavivirus xrRNA. Rna, 27, 2021
4OBY	Crystal Structure of E.coli Arginyl-tRNA Synthetase and Ligand Binding Studies Revealed Key Residues in Arginine Recognition Descriptor: ARGININE, Arginine--tRNA ligase Authors: Bi, K, Zheng, Y, Dong, J, Gao, F, Wang, J, Wang, Y, Gong, W. Deposit date: 2014-01-08 Release date: 2014-02-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.574 Å) Cite: Crystal structure of E. coli arginyl-tRNA synthetase and ligand binding studies revealed key residues in arginine recognition. Protein Cell, 5, 2014
4PHC	Crystal Structure of a human cytosolic histidyl-tRNA synthetase, histidine-bound Descriptor: GLYCEROL, HISTIDINE, Histidine--tRNA ligase, ... Authors: Koh, C.Y, Wetzel, A.B, de van der Schueren, W.J, Hol, W.G.J. Deposit date: 2014-05-06 Release date: 2014-08-27 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.844 Å) Cite: Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases. Biochimie, 106, 2014
3MJB	Cricket Paralysis Virus IGR IRES Domain 3 RNA bound to sulfate Descriptor: Domain 3 of the cricket paralysis virus intergenic region IRES RNA, RNA (5'-R(P*UP*AP*AP*GP*AP*AP*AP*UP*UP*UP*AP*CP*CP*U)-3'), SULFATE ION Authors: Kieft, J.S, Golden, B.L, Costantino, D.A, Chase, E. Deposit date: 2010-04-12 Release date: 2010-05-19 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Identification and characterization of anion binding sites in RNA. Rna, 16, 2010
3MJ3	Cricket Paralysis Virus IGR IRES Domain 3 RNA bound to selenate Descriptor: Domain 3 of the cricket paralysis virus intergenic region IRES RNA, RNA (5'-R(P*UP*AP*AP*GP*AP*AP*AP*UP*UP*UP*AP*CP*CP*U)-3'), SELENATE ION Authors: Kieft, J.S, Chase, E, Costantino, D.A, Golden, B.L. Deposit date: 2010-04-12 Release date: 2010-05-19 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Identification and characterization of anion binding sites in RNA. Rna, 16, 2010
3MJA	Cricket Paralysis Virus IGR IRES Domain 3 RNA bound to selenate, structure #2 Descriptor: Domain 3 of the cricket paralysis virus intergenic region IRES RNA, RNA (5'-R(P*UP*AP*AP*GP*AP*AP*AP*UP*UP*UP*AP*CP*CP*U)-3'), SELENATE ION Authors: Kieft, J.S, Golden, B.L, Costantino, D.A, Chase, E. Deposit date: 2010-04-12 Release date: 2010-05-19 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Identification and characterization of anion binding sites in RNA. Rna, 16, 2010
2XC7	Solution Structure of PHAX-RBD in complex with ssRNA Descriptor: 5'-(AP*UP*CP*GP)-3', PHOSPHORYLATED ADAPTER RNA EXPORT PROTEIN Authors: Mourao, A, Mackereth, C.D, Varrot, A, Cusack, S, Sattler, M. Deposit date: 2010-04-18 Release date: 2010-04-28 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structure and RNA Recognition by the Snrna and Snorna Transport Factor Phax. RNA, 16, 2010
3DD2	Crystal structure of an RNA aptamer bound to human thrombin Descriptor: ACETIC ACID, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, DI(HYDROXYETHYL)ETHER, ... Authors: Long, S.B, Sullenger, B.A. Deposit date: 2008-06-04 Release date: 2008-11-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of an RNA aptamer bound to thrombin. Rna, 14, 2008
1WQ3	Escherichia coli tyrosyl-tRNA synthetase mutant complexed with 3-iodo-L-tyrosine Descriptor: 3-IODO-TYROSINE, Tyrosyl-tRNA synthetase Authors: Kobayashi, T, Sakamoto, K, Nureki, O, Takimura, T, Kamata, K, Sekine, R, Nishimura, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2004-09-20 Release date: 2005-01-25 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis of nonnatural amino acid recognition by an engineered aminoacyl-tRNA synthetase for genetic code expansion Proc.Natl.Acad.Sci.USA, 102, 2005
7FAL	Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with T36 and L-pro Descriptor: 4-[(3R)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, Prolyl-tRNA synthetase (ProRS) Authors: Malhotra, N, Mishra, S, Yogavel, M, Sharma, A. Deposit date: 2021-07-06 Release date: 2022-08-31 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.219 Å) Cite: Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
7FAN	Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with T35 and L-pro Descriptor: 4-[(3S)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, Prolyl-tRNA synthetase (ProRS) Authors: Mishra, S, Malhotra, N, Yogavel, M, Sharma, A. Deposit date: 2021-07-06 Release date: 2022-09-28 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.769 Å) Cite: Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
7FAM	Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with L97 and L-pro Descriptor: 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, Prolyl-tRNA synthetase (ProRS) Authors: Mishra, S, Malhotra, N, Yogavel, M, Sharma, A. Deposit date: 2021-07-06 Release date: 2022-09-28 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
4WI1	Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with TCMDC-124506 Descriptor: 1,2-ETHANEDIOL, 1-(4-fluorophenyl)-3-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea, CHLORIDE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2014-09-25 Release date: 2016-05-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase. Acs Infect Dis., 2016
7FAK	Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with L96 and L-pro Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, ACETATE ION, ... Authors: Malhotra, N, Mishra, S, Yogavel, M, Sharma, A. Deposit date: 2021-07-06 Release date: 2023-02-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.899 Å) Cite: Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis. Plos Pathog., 19, 2023
1NYR	Structure of Staphylococcus aureus threonyl-tRNA synthetase complexed with ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, THREONINE, ZINC ION, ... Authors: Torres-Larios, A, Sankaranarayanan, R, Rees, B, Dock-Bregeon, A.C, Moras, D. Deposit date: 2003-02-13 Release date: 2003-10-28 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Conformational movements and cooperativity upon amino acid, ATP and tRNA binding in threonyl-tRNA synthetase J.Mol.Biol., 331, 2003

<15161718192021222324252627282930>