8X31
 
 | | The piccolo NuA4 bound to the H2A.Z nucleosome complex with Ac-CoA at resetting state | | Descriptor: | Chromatin modification-related protein, DNA (146-MER), Histone H2A, ... | | Authors: | Wang, L, Zhang, H, Zhu, H, Zhu, P. | | Deposit date: | 2023-11-10 | | Release date: | 2025-03-19 | | Last modified: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (6.2 Å) | | Cite: | Cryo-EM structures reveal the acetylation process of piccolo NuA4.
Proc.Natl.Acad.Sci.USA, 122, 2025
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8X2Y
 | | The class1 of piccolo NuA4 bound to the H2A.Z nucleosome complex at harboring state | | Descriptor: | Chromatin modification-related protein, DNA (146-MER), Histone H2A, ... | | Authors: | Wang, L, Zhang, H, Zhu, H, Zhu, P. | | Deposit date: | 2023-11-10 | | Release date: | 2025-03-19 | | Last modified: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Cryo-EM structures reveal the acetylation process of piccolo NuA4.
Proc.Natl.Acad.Sci.USA, 122, 2025
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8ZJ2
 | | Cryo-EM structure of the RhoG/DOCK5/ELMO1/Rac1 complex | | Descriptor: | Dedicator of cytokinesis protein 5, Engulfment and cell motility protein 1, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Kukimoto-Niino, M, Katsura, K, Ishizuka-Katsura, Y, Mishima-Tsumagari, C, Yonemochi, M, Inoue, M, Nakagawa, R, Kaushik, R, Zhang, K.Y.J, Shirouzu, M. | | Deposit date: | 2024-05-14 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (4.66 Å) | | Cite: | RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state.
J.Biol.Chem., 300, 2024
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8ESC
 | | Structure of the Yeast NuA4 Histone Acetyltransferase Complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, Actin-related protein 4, ... | | Authors: | Patel, A.B, Zukin, S.A, Nogales, E. | | Deposit date: | 2022-10-13 | | Release date: | 2022-11-16 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structure and flexibility of the yeast NuA4 histone acetyltransferase complex.
Elife, 11, 2022
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2FSP
 | | NMR SOLUTION STRUCTURE OF BACILLUS SUBTILIS SPO0F PROTEIN, MINIMIZED AVERAGE STRUCTURE | | Descriptor: | STAGE 0 SPORULATION PROTEIN F | | Authors: | Feher, V.A, Skelton, N.J, Dahlquist, F.W, Cavanagh, J. | | Deposit date: | 1997-06-06 | | Release date: | 1997-12-10 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | High-resolution NMR structure and backbone dynamics of the Bacillus subtilis response regulator, Spo0F: implications for phosphorylation and molecular recognition.
Biochemistry, 36, 1997
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6HTS
 | | Cryo-EM structure of the human INO80 complex bound to nucleosome | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... | | Authors: | Ayala, R, Willhoft, O, Aramayo, R.J, Wilkinson, M, McCormack, E.A, Ocloo, L, Wigley, D.B, Zhang, X. | | Deposit date: | 2018-10-04 | | Release date: | 2018-11-07 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Structure and regulation of the human INO80-nucleosome complex.
Nature, 556, 2018
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8Z6O
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8Z6C
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8GXP
 | | Complex structure of RORgama with betulinic acid | | Descriptor: | Betulinic acid, Nuclear receptor ROR-gamma | | Authors: | Zhang, X.L, Xu, C, Bai, F. | | Deposit date: | 2022-09-20 | | Release date: | 2023-06-07 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of ROR gamma antagonists.
Eur.J.Med.Chem., 257, 2023
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4UAK
 | | MRCK beta in complex with ADP | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | | Authors: | Schuettelkopf, A.W. | | Deposit date: | 2014-08-10 | | Release date: | 2014-10-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | A novel small-molecule MRCK inhibitor blocks cancer cell invasion.
Cell Commun. Signal, 12, 2014
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4UAL
 | | MRCK beta in complex with BDP00005290 | | Descriptor: | 1,2-ETHANEDIOL, 4-chloro-1-(piperidin-4-yl)-N-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]-1H-pyrazole-3-carboxamide, CHLORIDE ION, ... | | Authors: | Schuettelkopf, A.W. | | Deposit date: | 2014-08-10 | | Release date: | 2014-10-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | A novel small-molecule MRCK inhibitor blocks cancer cell invasion.
Cell Commun. Signal, 12, 2014
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8ZYP
 | | Cryo-EM Structure of E-4031-bound hERG Channel | | Descriptor: | Potassium voltage-gated channel subfamily H member 2, ~{N}-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidin-4-yl]carbonylphenyl]methanesulfonamide | | Authors: | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | Deposit date: | 2024-06-18 | | Release date: | 2024-09-18 | | Last modified: | 2024-11-27 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Improved higher resolution cryo-EM structures reveal the binding modes of hERG channel inhibitors.
Structure, 32, 2024
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8ZYN
 | | Cryo-EM Structure of inhibitor-free hERG Channel | | Descriptor: | Potassium voltage-gated channel subfamily H member 2 | | Authors: | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | Deposit date: | 2024-06-18 | | Release date: | 2024-09-18 | | Last modified: | 2024-11-27 | | Method: | ELECTRON MICROSCOPY (3.27 Å) | | Cite: | Improved higher resolution cryo-EM structures reveal the binding modes of hERG channel inhibitors.
Structure, 32, 2024
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8I02
 | | Cryo-EM structure of the SIN3S complex from S. pombe | | Descriptor: | Chromatin modification-related protein eaf3, Cph1, Histone deacetylase clr6, ... | | Authors: | Wang, C, Guo, Z, Zhan, X. | | Deposit date: | 2023-01-10 | | Release date: | 2023-05-03 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Two assembly modes for SIN3 histone deacetylase complexes.
Cell Discov, 9, 2023
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8I03
 | | Cryo-EM structure of the SIN3L complex from S. pombe | | Descriptor: | Chromatin modification-related protein png2, Histone deacetylase clr6, POTASSIUM ION, ... | | Authors: | Wang, C, Guo, Z, Zhan, X. | | Deposit date: | 2023-01-10 | | Release date: | 2023-05-03 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Two assembly modes for SIN3 histone deacetylase complexes.
Cell Discov, 9, 2023
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8I3G
 | | Crystal structure of Eaf3-Eaf7 complex | | Descriptor: | Chromatin modification-related protein EAF3, Chromatin modification-related protein EAF7 | | Authors: | Chen, Z, Xu, C. | | Deposit date: | 2023-01-17 | | Release date: | 2023-05-31 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4.
Cell Discov, 9, 2023
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4UST
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9B85
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9B7J
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8ZYO
 | | Cryo-EM Structure of astemizole-bound hERG Channel | | Descriptor: | 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, Potassium voltage-gated channel subfamily H member 2 | | Authors: | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | Deposit date: | 2024-06-18 | | Release date: | 2024-09-18 | | Last modified: | 2024-11-27 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Improved higher resolution cryo-EM structures reveal the binding modes of hERG channel inhibitors.
Structure, 32, 2024
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8ZYQ
 | | Cryo-EM Structure of pimozide-bound hERG Channel | | Descriptor: | 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1~{H}-benzimidazol-2-one, Potassium voltage-gated channel subfamily H member 2 | | Authors: | Miyashita, Y, Moriya, T, Kato, T, Kawasaki, M, Yasuda, Y, Adachi, N, Suzuki, K, Ogasawara, S, Saito, T, Senda, T, Murata, T. | | Deposit date: | 2024-06-18 | | Release date: | 2024-09-18 | | Last modified: | 2024-11-27 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Improved higher resolution cryo-EM structures reveal the binding modes of hERG channel inhibitors.
Structure, 32, 2024
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4ZCH
 | | Single-chain human APRIL-BAFF-BAFF Heterotrimer | | Descriptor: | TRIS-HYDROXYMETHYL-METHYL-AMMONIUM, Tumor necrosis factor ligand superfamily member 13,Tumor necrosis factor ligand superfamily member 13B,Tumor necrosis factor ligand superfamily member 13B | | Authors: | Lammens, A, Jiang, X, Maskos, K, Schneider, P. | | Deposit date: | 2015-04-16 | | Release date: | 2015-05-13 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties.
J.Biol.Chem., 290, 2015
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8IYJ
 | | Cryo-EM structure of the 48-nm repeat doublet microtubule from mouse sperm | | Descriptor: | Cilia and flagella-associated protein 77, Cilia- and flagella-associated protein 107, Cilia- and flagella-associated protein 141, ... | | Authors: | Zhou, L.N, Gui, M, Wu, J.P. | | Deposit date: | 2023-04-05 | | Release date: | 2023-07-05 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility.
Cell, 186, 2023
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9B62
 | | Human RANBP2/RAN(GTP)/RANGAP1-SUMO1/UBC9/CRM1/RAN(GTP) - composite map and model | | Descriptor: | E3 SUMO-protein ligase RanBP2, Exportin-1, GTP-binding nuclear protein Ran, ... | | Authors: | Lima, C.D, DiMattia, M.A. | | Deposit date: | 2024-03-23 | | Release date: | 2024-10-16 | | Last modified: | 2025-04-30 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase.
Biorxiv, 2024
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8P7A
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