6AUI
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![BU of 6aui by Molmil](/molmil-images/mine/6aui) | Human ribonucleotide reductase large subunit (alpha) with dATP and CDP | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Brignole, E.J, Drennan, C.L, Asturias, F.J, Tsai, K.L, Penczek, P.A. | Deposit date: | 2017-09-01 | Release date: | 2018-04-18 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | 3.3- angstrom resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. Elife, 7, 2018
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3O0Q
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![BU of 3o0q by Molmil](/molmil-images/mine/3o0q) | Thermotoga maritima Ribonucleotide Reductase, NrdJ, in complex with dTTP, GDP and Adenosine | Descriptor: | ADENOSINE, CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Larsson, K.-M, Logan, D.T, Nordlund, P. | Deposit date: | 2010-07-19 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Basis for Adenosylcobalamin Activation in AdoCbl-Dependent Ribonucleotide Reductases. Acs Chem.Biol., 5, 2010
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1PEO
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![BU of 1peo by Molmil](/molmil-images/mine/1peo) | Ribonucleotide Reductase Protein R1E from Salmonella typhimurium | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase 2 alpha chain | Authors: | Uppsten, M, Farnegardh, M, Jordan, A, Eliasson, R, Eklund, H, Uhlin, U. | Deposit date: | 2003-05-22 | Release date: | 2004-05-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of the large subunit of class Ib ribonucleotide reductase from Salmonella typhimurium and its complexes with allosteric effectors. J.Mol.Biol., 330, 2003
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1PEM
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![BU of 1pem by Molmil](/molmil-images/mine/1pem) | Ribonucleotide Reductase Protein R1E from Salmonella typhimurium | Descriptor: | Ribonucleoside-diphosphate reductase 2 alpha chain | Authors: | Uppsten, M, Farnegardh, M, Jordan, A, Eliasson, R, Eklund, H, Uhlin, U. | Deposit date: | 2003-05-22 | Release date: | 2004-05-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Structure of the large subunit of class Ib ribonucleotide reductase from Salmonella typhimurium and its complexes with allosteric effectors. J.Mol.Biol., 330, 2003
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3O0O
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![BU of 3o0o by Molmil](/molmil-images/mine/3o0o) | Thermotoga maritima Ribonucleotide Reductase, NrdJ, in complex with dTTP, GDP and Adenosylcobalamin | Descriptor: | 5'-DEOXYADENOSINE, COBALAMIN, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Larsson, K.-M, Logan, D.T, Nordlund, P. | Deposit date: | 2010-07-19 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis for Adenosylcobalamin Activation in AdoCbl-Dependent Ribonucleotide Reductases. Acs Chem.Biol., 5, 2010
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1PEQ
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![BU of 1peq by Molmil](/molmil-images/mine/1peq) | Ribonucleotide Reductase Protein R1E from Salmonella typhimurium | Descriptor: | MAGNESIUM ION, Ribonucleoside-diphosphate reductase 2 alpha chain, THYMIDINE-5'-TRIPHOSPHATE | Authors: | Uppsten, M, Farnegardh, M, Jordan, A, Eliasson, R, Eklund, H, Uhlin, U. | Deposit date: | 2003-05-22 | Release date: | 2004-05-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of the large subunit of class Ib ribonucleotide reductase from Salmonella typhimurium and its complexes with allosteric effectors. J.Mol.Biol., 330, 2003
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1PEU
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![BU of 1peu by Molmil](/molmil-images/mine/1peu) | Ribonucleotide Reductase Protein R1E from Salmonella typhimurium | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase 2 alpha chain | Authors: | Uppsten, M, Farnegardh, M, Jordan, A, Eliasson, R, Eklund, H, Uhlin, U. | Deposit date: | 2003-05-22 | Release date: | 2004-05-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of the large subunit of class Ib ribonucleotide reductase from Salmonella typhimurium and its complexes with allosteric effectors. J.Mol.Biol., 330, 2003
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3PAW
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![BU of 3paw by Molmil](/molmil-images/mine/3paw) | |
6CGN
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![BU of 6cgn by Molmil](/molmil-images/mine/6cgn) | |
6CGM
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![BU of 6cgm by Molmil](/molmil-images/mine/6cgm) | |
6CGL
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![BU of 6cgl by Molmil](/molmil-images/mine/6cgl) | |
5CNS
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![BU of 5cns by Molmil](/molmil-images/mine/5cns) | Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to CDP and dATP at 2.97 Angstroms resolution | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, ... | Authors: | Chen, P.Y.-T, Zimanyi, C.M, Funk, M.A, Drennan, C.L. | Deposit date: | 2015-07-18 | Release date: | 2016-01-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.975 Å) | Cite: | Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife, 5, 2016
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3K8T
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![BU of 3k8t by Molmil](/molmil-images/mine/3k8t) | Structure of eukaryotic rnr large subunit R1 complexed with designed adp analog compound | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2'-deoxy-2'-(2-hydroxyethyl)adenosine 5'-(trihydrogen diphosphate), GLYCEROL, ... | Authors: | Sun, D, Xu, H, Dealwis, C, Lee, R.E. | Deposit date: | 2009-10-14 | Release date: | 2010-03-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-Based Design, Synthesis, and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors Chemmedchem, 4, 2009
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5CNT
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![BU of 5cnt by Molmil](/molmil-images/mine/5cnt) | Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to UDP and dATP at 3.25 Angstroms resolution | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, MU-OXO-DIIRON, ... | Authors: | Chen, P.Y.-T, Zimanyi, C.M, Funk, M.A, Drennan, C.L. | Deposit date: | 2015-07-18 | Release date: | 2016-01-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife, 5, 2016
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5CNU
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![BU of 5cnu by Molmil](/molmil-images/mine/5cnu) | Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to ADP and dGTP at 3.40 Angstroms resolution | Descriptor: | 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Chen, P.Y.-T, Zimanyi, C.M, Funk, M.A, Drennan, C.L. | Deposit date: | 2015-07-18 | Release date: | 2016-01-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife, 5, 2016
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5D1Y
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![BU of 5d1y by Molmil](/molmil-images/mine/5d1y) | Low resolution crystal structure of human ribonucleotide reductase alpha6 hexamer in complex with dATP | Descriptor: | Ribonucleoside-diphosphate reductase large subunit | Authors: | Ando, N, Li, H, Brignole, E.J, Thompson, S, McLaughlin, M.I, Page, J, Asturias, F, Stubbe, J, Drennan, C.L. | Deposit date: | 2015-08-04 | Release date: | 2016-01-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (9.005 Å) | Cite: | Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer. Biochemistry, 55, 2016
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3HNC
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![BU of 3hnc by Molmil](/molmil-images/mine/3hnc) | Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP | Descriptor: | MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, SULFATE ION, ... | Authors: | Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. | Deposit date: | 2009-05-31 | Release date: | 2011-02-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
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3HNE
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![BU of 3hne by Molmil](/molmil-images/mine/3hne) | Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... | Authors: | Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. | Deposit date: | 2009-05-31 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
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3HND
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![BU of 3hnd by Molmil](/molmil-images/mine/3hnd) | Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP and substrate GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... | Authors: | Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. | Deposit date: | 2009-05-31 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
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3HNF
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![BU of 3hnf by Molmil](/molmil-images/mine/3hnf) | Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and dATP | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... | Authors: | Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. | Deposit date: | 2009-05-31 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.16 Å) | Cite: | Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
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5CNV
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![BU of 5cnv by Molmil](/molmil-images/mine/5cnv) | Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to GDP and TTP at 3.20 Angstroms resolution | Descriptor: | 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Chen, P.Y.-T, Zimanyi, C.M, Funk, M.A, Drennan, C.L. | Deposit date: | 2015-07-18 | Release date: | 2016-01-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife, 5, 2016
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3R1R
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![BU of 3r1r by Molmil](/molmil-images/mine/3r1r) | |
6L3R
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![BU of 6l3r by Molmil](/molmil-images/mine/6l3r) | Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide | Descriptor: | 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide, ACETATE ION, MAGNESIUM ION, ... | Authors: | Miyahara, S, Chong, K.T, Suzuki, T. | Deposit date: | 2019-10-15 | Release date: | 2020-10-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published
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6L7L
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![BU of 6l7l by Molmil](/molmil-images/mine/6l7l) | Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide | Descriptor: | 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide, ACETATE ION, MAGNESIUM ION, ... | Authors: | Miyahara, S, Chong, K.T, Suzuki, T. | Deposit date: | 2019-11-01 | Release date: | 2020-11-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.171 Å) | Cite: | TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published
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3S87
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![BU of 3s87 by Molmil](/molmil-images/mine/3s87) | Structure of Yeast Ribonucleotide Reductase 1 with dGTP and ADP | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. | Deposit date: | 2011-05-27 | Release date: | 2012-04-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
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