6XYP
 
 | | Multiple system atrophy Type II-1 alpha-synuclein filament | | Descriptor: | Alpha-synuclein | | Authors: | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | | Deposit date: | 2020-01-30 | | Release date: | 2020-02-12 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Structures of alpha-synuclein filaments from multiple system atrophy.
Nature, 585, 2020
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8GF7
 | | Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-synuclein fibrils | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-synuclein | | Authors: | Balana, J.A, Nguyen, A.B, Saelices, L, Pratt, R.M. | | Deposit date: | 2023-03-07 | | Release date: | 2023-11-08 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | O-GlcNAc forces an alpha-synuclein amyloid strain with notably diminished seeding and pathology.
Nat.Chem.Biol., 20, 2024
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6OSJ
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6RT0
 | | cryo-em structure of alpha-synuclein fibril polymorph 2A | | Descriptor: | Alpha-synuclein | | Authors: | Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. | | Deposit date: | 2019-05-22 | | Release date: | 2019-06-26 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.
Elife, 8, 2019
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6OSL
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8H05
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6RTB
 | | cryo-em structure of alpha-synuclein fibril polymorph 2B | | Descriptor: | Alpha-synuclein | | Authors: | Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. | | Deposit date: | 2019-05-22 | | Release date: | 2019-06-26 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.
Elife, 8, 2019
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6L1T
 | | Cryo-EM structure of phosphorylated Tyr39 a-synuclein amyloid fibril | | Descriptor: | Alpha-synuclein | | Authors: | Liu, C, Li, Y.M, Zhao, K, Lim, Y.J, Liu, Z.Y. | | Deposit date: | 2019-09-30 | | Release date: | 2020-08-12 | | Last modified: | 2020-09-02 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | Parkinson's disease-related phosphorylation at Tyr39 rearranges alpha-synuclein amyloid fibril structure revealed by cryo-EM.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6L1U
 | | Cryo-EM structure of phosphorylated Tyr39 alpha-synuclein amyloid fibril | | Descriptor: | Alpha-synuclein | | Authors: | Liu, C, Li, Y.M, Zhao, K, Lim, Y.J, Liu, Z.Y. | | Deposit date: | 2019-09-30 | | Release date: | 2020-08-12 | | Last modified: | 2020-09-02 | | Method: | ELECTRON MICROSCOPY (3.37 Å) | | Cite: | Parkinson's disease-related phosphorylation at Tyr39 rearranges alpha-synuclein amyloid fibril structure revealed by cryo-EM.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6L4S
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6LRQ
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8HZC
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8HZB
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8HZS
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8JEX
 | | Cryo-EM structure of alpha-synuclein gS87 fibril | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-synuclein, unverified amino acid chain | | Authors: | Xia, W.C, Sun, Y.P, Liu, C. | | Deposit date: | 2023-05-16 | | Release date: | 2024-04-17 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures.
Nat Commun, 15, 2024
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8JEY
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9EUU
 | | Structure of recombinant alpha-synuclein fibrils 1B capable of seeding GCIs in vivo | | Descriptor: | Alpha-synuclein | | Authors: | Burger, D, Kashyrina, M, Lewis, A, De Nuccio, F, Mohammed, I, de La Seigliere, H, van den Heuvel, L, Feuillie, C, Verchere, J, Berbon, M, Arotcarena, M, Retailleau, A, Bezard, E, Laferriere, F, Loquet, A, Bousset, L, Baron, T, Lofrumento, D.D, De Giorgi, F, Stahlberg, H, Ichas, F. | | Deposit date: | 2024-03-28 | | Release date: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (1.93 Å) | | Cite: | Multiple System Atrophy: Insights from aSyn Fibril Structure
To Be Published
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8ZWI
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8ZWH
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8ZWK
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8ZWJ
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9CK3
 | | Cryo-EM structure of in-vitro alpha-synuclein fibril | | Descriptor: | Alpha-synuclein | | Authors: | Sanchez, J.C, Borcik, C.G, Tonelli, M, Sibert, B, Rienstra, C.M, Wright, E.R. | | Deposit date: | 2024-07-08 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (2.04 Å) | | Cite: | Multimodal High-Resolution Structure Determination Of Alpha-Synuclein Fibrils
To Be Published
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8RRR
 | | Alpha-synuclein amyloid fibril | | Descriptor: | Alpha-synuclein | | Authors: | Saibil, H.R, Monistrol, J. | | Deposit date: | 2024-01-23 | | Release date: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Stepwise recruitment of Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibre disassembly
Biorxiv, 2024
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8RQM
 | | Alpha-synuclein amyloid fibrils | | Descriptor: | Alpha-synuclein | | Authors: | Saibil, H.R, Monistrol, J. | | Deposit date: | 2024-01-18 | | Release date: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Stepwise recruitment of Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibre disassembly
Biorxiv, 2024
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8RI9
 | | Late alpha-Synuclein fibril structure from liquid-liquid phase separations. | | Descriptor: | Alpha-synuclein | | Authors: | De Simone, A, Barritt, J.D, Chen, S, Cascella, R, Cecchi, C, Bigi, A, Jarvis, J.A, Chiti, F, Dobson, C.M, Fusco, G. | | Deposit date: | 2023-12-18 | | Release date: | 2024-03-06 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure-Toxicity Relationship in Intermediate Fibrils from alpha-Synuclein Condensates.
J.Am.Chem.Soc., 146, 2024
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