PDB: 97 resultsInfo pagesStatus searchChemie searchBIRD

---

5IWG	HDAC2 WITH LIGAND BRD4884 Descriptor: 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... Authors: Steinbacher, S. Deposit date: 2016-03-22 Release date: 2016-08-31 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg.Med.Chem., 24, 2016
5IX0	HDAC2 WITH LIGAND BRD7232 Descriptor: (3-exo)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-8-oxabicyclo[3.2.1]octane-3-carboxamide, 1,2-ETHANEDIOL, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, ... Authors: Steinbacher, S. Deposit date: 2016-03-23 Release date: 2016-08-31 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg.Med.Chem., 24, 2016
9CBH	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with p-Aminomethyl Phenylthioketone Descriptor: 1-[4-(aminomethyl)phenyl]-2-sulfanylethan-1-one, PHOSPHATE ION, POTASSIUM ION, ... Authors: Goulart Stollmaier, J, Christianson, D.W. Deposit date: 2024-06-19 Release date: 2024-09-11 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10 To be Published
9CBJ	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with p-Aminopropyl Phenylthioketone Descriptor: 1,2-ETHANEDIOL, 1-[4-(3-aminopropyl)phenyl]-2-sulfanylethan-1-one, PHOSPHATE ION, ... Authors: Goulart Stollmaier, J, Christianson, D.W. Deposit date: 2024-06-19 Release date: 2024-09-11 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10 To be Published
9CBI	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with p-Aminoethyl Phenylthioketone Descriptor: 1,2-ETHANEDIOL, 1-[4-(2-aminoethyl)phenyl]-2-sulfanylethan-1-one, PHOSPHATE ION, ... Authors: Goulart Stollmaier, J, Christianson, D.W. Deposit date: 2024-06-19 Release date: 2024-09-11 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10 To be Published
9CBF	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with m-Aminomethyl Phenylthioketone Descriptor: 1,2-ETHANEDIOL, 1-[3-(aminomethyl)phenyl]-2-sulfanylethan-1-one, PHOSPHATE ION, ... Authors: Goulart Stollmaier, J, Christianson, D.W. Deposit date: 2024-06-19 Release date: 2024-09-11 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Design, Synthesis and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10 To Be Published
9CBG	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with m-Aminoethyl Phenylthioketone Descriptor: 1,2-ETHANEDIOL, 1-[3-(2-aminoethyl)phenyl]-2-sulfanylethan-1-one, PHOSPHATE ION, ... Authors: Goulart Stollmaier, J, Christianson, D.W. Deposit date: 2024-06-19 Release date: 2024-09-11 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10 To be Published
1OW1	Crystal structure of the SPOC domain of the human transcriptional corepressor, SHARP. Descriptor: SMART/HDAC1 associated repressor protein Authors: Schwabe, J.W, Ariyoshi, M. Deposit date: 2003-03-28 Release date: 2003-08-19 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling Genes Dev., 17, 2003
7SMF	p107 pocket domain complexed with mutated HDAC1-3X peptide Descriptor: Histone deacetylase 1, Retinoblastoma-like protein 1, SULFATE ION Authors: Putta, S, Fernandez, S.M, Tripathi, S.M, Muller, G.A, Rubin, S.M. Deposit date: 2021-10-25 Release date: 2022-06-29 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family. Structure, 30, 2022
6VNQ	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Bishydroxamic Acid Based Inhibitor Descriptor: 1,2-ETHANEDIOL, N-hydroxy-1-{[4-(hydroxycarbamoyl)phenyl]methyl}-1H-indole-6-carboxamide, PHOSPHATE ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2020-01-29 Release date: 2020-05-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors. Chemmedchem, 15, 2020
7KUR	Crystal Structure of Danio rerio Histone Deacetylase 10 Y307F Mutant in Complex with N-Acetylputrescine Descriptor: DI(HYDROXYETHYL)ETHER, N-(4-aminobutyl)acetamide, PHOSPHATE ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2020-11-25 Release date: 2021-02-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10. Biochemistry, 60, 2021
7KUT	Crystal Structure of Danio rerio Histone Deacetylase 10 H137A Mutant in Complex with N-Acetylputrescine (Tetrahedral Intermediate) Descriptor: 1,2-ETHANEDIOL, 1-[(4-aminobutyl)amino]ethane-1,1-diol, DI(HYDROXYETHYL)ETHER, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2020-11-25 Release date: 2021-02-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.05 Å) Cite: X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10. Biochemistry, 60, 2021
7KUV	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Acetate Descriptor: 1,2-ETHANEDIOL, ACETATE ION, PHOSPHATE ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2020-11-25 Release date: 2021-02-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.15 Å) Cite: X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10. Biochemistry, 60, 2021
7KUS	Crystal Structure of Danio rerio Histone Deacetylase 10 H137A Mutant in Complex with N8-Acetylspermidine (Tetrahedral Intermediate) Descriptor: 1,2-ETHANEDIOL, 1-({4-[(3-aminopropyl)amino]butyl}amino)ethane-1,1-diol, DI(HYDROXYETHYL)ETHER, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2020-11-25 Release date: 2021-02-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2 Å) Cite: X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10. Biochemistry, 60, 2021
7KUQ	Crystal Structure of Danio rerio Histone Deacetylase 10 Y307F Mutant in Complex with N8-Acetylspermidine Descriptor: N-{4-[(3-aminopropyl)amino]butyl}acetamide, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2020-11-25 Release date: 2021-02-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10. Biochemistry, 60, 2021
6UFN	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with 7-[(3-aminopropyl)amino]heptan-2-one Descriptor: 7-[(3-aminopropyl)amino]heptane-2,2-diol, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2019-09-24 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Binding ofN8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry, 58, 2019
6UFO	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with 7-[(3-aminopropyl)amino]-1-methoxyheptan-2-one Descriptor: 7-[(3-aminopropyl)amino]-1-methoxyheptane-2,2-diol, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2019-09-24 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.68 Å) Cite: Binding ofN8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry, 58, 2019
6UHV	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with 6-[(3-aminopropyl)amino]-N-hydroxyhexanamide Descriptor: 6-[(3-aminopropyl)amino]-N-hydroxyhexanamide, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2019-09-28 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Binding ofN8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry, 58, 2019
6UII	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with 5-[(3-aminopropyl)amino]pentane-1-thiol Descriptor: 5-[(3-aminopropyl)amino]pentane-1-thiol, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2019-10-01 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Binding ofN8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry, 58, 2019
6UHU	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with 5-[(3-aminopropyl)amino]pentylboronic acid Descriptor: 5-(3-azanylpropylamino)pentyl-$l^{3}-oxidanyl-bis(oxidanyl)boron, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2019-09-28 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Binding ofN8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry, 58, 2019
6UIM	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with 7-{[(3-aminopropyl)amino]-2-oxoheptyl} thioacetate Descriptor: 7-[(3-aminopropyl)amino]-1-sulfanylheptan-2-one, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2019-10-01 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Binding ofN8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry, 58, 2019
6UIL	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-one Descriptor: 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptane-2,2-diol, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2019-10-01 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Binding ofN8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry, 58, 2019
6UIJ	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with S-{5-[(3-aminopropyl)amino]pentyl} thioacetate Descriptor: 5-[(3-aminopropyl)amino]pentane-1-thiol, PHOSPHATE ION, POTASSIUM ION, ... Authors: Herbst-Gervasoni, C.J, Christianson, D.W. Deposit date: 2019-10-01 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Binding ofN8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry, 58, 2019
9CBK	Crystal Structure of Danio rerio Histone Deacetylase 6 in Complex with p-Aminomethyl Phenylthioketone Descriptor: 1,2-ETHANEDIOL, 1-[4-(aminomethyl)phenyl]-2-sulfanylethan-1-one, Hdac6 protein, ... Authors: Goulart Stollmaier, J, Watson, P.R, Christianson, D.W. Deposit date: 2024-06-19 Release date: 2024-09-11 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10 To be Published
4CZZ	Histone demethylase LSD1(KDM1A)-CoREST3 Complex Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 3 Authors: Barrios, A.P, Gomez, A.V, Saez, J.E, Ciossani, G, Toffolo, E, Battaglioli, E, Mattevi, A, Andres, M.E. Deposit date: 2014-04-23 Release date: 2014-06-11 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Differential Properties of Transcriptional Complexes Formed by the Corest Family. Mol.Cell.Biol., 34, 2014

<1234>