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1ZFK
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BU of 1zfk by Molmil
carbonic anhydrase II in complex with N-4-sulfonamidphenyl-N'-4-methylbenzosulfonylurease as sulfonamide inhibitor
Descriptor: (4-CARBOXYPHENYL)(CHLORO)MERCURY, Carbonic anhydrase II, GLYCEROL, ...
Authors:Honndorf, V.S, Heine, A, Klebe, G, Supuran, C.T.
Deposit date:2005-04-20
Release date:2006-05-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:carbonic anhydrase II in complex with N-4-sulfonamidphenyl-N'-4-methylbenzosulfonylurease as sulfonamide inhibitor
To be Published
2NXR
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BU of 2nxr by Molmil
Structural effects of hydrophobic mutations on the active site of human carbonic anhydrase II
Descriptor: SULFATE ION, ZINC ION, carbonic anhydrase 2
Authors:Fisher, S.Z, McKenna, R.
Deposit date:2006-11-19
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2OSM
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BU of 2osm by Molmil
Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study
Descriptor: 2-MERCAPTOPHENOL, Carbonic anhydrase 2, ZINC ION
Authors:Albert, A.B, Caroli, G, Govindasamy, L, Agbandje-Mckenna, M, McKenna, R, Tripp, B.C.
Deposit date:2007-02-06
Release date:2008-02-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study.
Biochemistry, 47, 2008
1XEG
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BU of 1xeg by Molmil
Crystal structure of human carbonic anhydrase II complexed with an acetate ion
Descriptor: ACETATE ION, Carbonic anhydrase II, ZINC ION
Authors:Mazumdar, P.A, Kumaran, D, Das, A.K, Swaminathan, S.
Deposit date:2004-09-10
Release date:2005-09-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:A novel acetate-bound complex of human carbonic anhydrase II.
Acta Crystallogr.,Sect.F, 64, 2008
1YDA
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BU of 1yda by Molmil
STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
Descriptor: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Nair, S.K, Christianson, D.W.
Deposit date:1994-12-22
Release date:1995-02-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of inhibitor affinity to variants of human carbonic anhydrase II.
Biochemistry, 34, 1995
2NXS
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BU of 2nxs by Molmil
Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
Descriptor: SULFATE ION, ZINC ION, carbonic anhydrase 2
Authors:Fisher, S.Z, McKenna, R.
Deposit date:2006-11-19
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NWO
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BU of 2nwo by Molmil
Structural and kinetic effect of hydrophobic mutations in the active site of human carbonic anhydrase II
Descriptor: Carbonic anhydrase 2, ZINC ION
Authors:Fisher, S.Z, McKenna, R.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2O4Z
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BU of 2o4z by Molmil
Crystal structure of the Carbonic Anhydrase II complexed with hydroxysulfamide inhibitor
Descriptor: Carbonic anhydrase 2, MERCURY (II) ION, N-hydroxysulfamide, ...
Authors:Temperini, C, Winum, J.Y, Montero, J.L, Scozzafava, a, Supuran, c.t.
Deposit date:2006-12-05
Release date:2007-05-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Carbonic anhydrase inhibitors: The X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
1XQ0
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BU of 1xq0 by Molmil
Structure of human carbonic anhydrase II with 4-[(3-bromo-4-O-sulfamoylbenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]-triazole
Descriptor: 2-BROMO-4-{[(4-CYANOPHENYL)(4H-1,2,4-TRIAZOL-4-YL)AMINO]METHYL}PHENYL SULFAMATE, Carbonic anhydrase II, ZINC ION
Authors:Lloyd, M.D, Thiyagarajan, N, Ho, Y.T, Woo, L.W.L, Sutcliffe, O.B, Purohit, A, Reed, M.J, Acharya, K.R, Potter, B.V.L.
Deposit date:2004-10-11
Release date:2005-05-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:First Crystal Structures of Human Carbonic Anhydrase II in Complex with Dual Aromatase-Steroid Sulfatase Inhibitors(,)
Biochemistry, 44, 2005
2NWP
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BU of 2nwp by Molmil
Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
Descriptor: SULFATE ION, ZINC ION, carbonic anhydrase 2
Authors:Fisher, S.Z, McKenna, R.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
1ZH9
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BU of 1zh9 by Molmil
carbonic anhydrase II in complex with N-4-Methyl-1-piperazinyl-N'-(p-sulfonamide)phenylthiourea as sulfonamide inhibitor
Descriptor: (4-CARBOXYPHENYL)(CHLORO)MERCURY, 4-({[(4-METHYLPIPERAZIN-1-YL)AMINO]CARBONOTHIOYL}AMINO)BENZENESULFONAMIDE, Carbonic anhydrase II, ...
Authors:Honndorf, V.S, Heine, A, Klebe, G, Supuran, C.T.
Deposit date:2005-04-23
Release date:2006-05-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:carbonic anhydrase II in complex with N-4-Methyl-1-piperazinyl-N'-(p-sulfonamide)phenylthiourea as sulfonamide inhibitor
To be Published
2NWY
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BU of 2nwy by Molmil
Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II
Descriptor: ZINC ION, carbonic anhydrase 2
Authors:Fisher, S.Z, McKenna, R.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
1ZE8
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BU of 1ze8 by Molmil
Carbonic anhydrase II in complex with a membrane-impermeant sulfonamide inhibitor
Descriptor: 1-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}-2,4,6-TRIMETHYLPYRIDINIUM, 4-(HYDROXYMERCURY)BENZOIC ACID, Carbonic anhydrase II, ...
Authors:Menchise, V, De Simone, G, Alterio, V, Di Fiore, A, Pedone, C, Scozzafava, A, Supuran, C.T.
Deposit date:2005-04-18
Release date:2005-10-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II
J.Med.Chem., 48, 2005
2NXT
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BU of 2nxt by Molmil
Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II
Descriptor: ZINC ION, carbonic anhydrase 2
Authors:Fisher, S.Z, McKenna, R.
Deposit date:2006-11-19
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2Q1B
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BU of 2q1b by Molmil
Carbonic Anhydrase II in Complex with Saccharin
Descriptor: 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, BENZOIC ACID, Carbonic anhydrase 2, ...
Authors:Klebe, G, Heine, A, Koehler, K.
Deposit date:2007-05-24
Release date:2007-09-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Saccharin Inhibits Carbonic Anhydrases: Possible Explanation for its Unpleasant Metallic Aftertaste.
Angew.Chem.Int.Ed.Engl., 46, 2007
2Q1Q
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BU of 2q1q by Molmil
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
Descriptor: Carbonic anhydrase 2, MERCURY (II) ION, SULTHIAME, ...
Authors:Temperini, C, Innocenti, A, Mastrolorenzo, A, Scozzafava, A, Supuran, C.T.
Deposit date:2007-05-25
Release date:2007-09-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: Kinetic and X-ray crystallographic studies.
Bioorg.Med.Chem.Lett., 17, 2007
2POW
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BU of 2pow by Molmil
The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide
Descriptor: 4-AMINO-6-(TRIFLUOROMETHYL)BENZENE-1,3-DISULFONAMIDE, Carbonic anhydrase 2, ZINC ION
Authors:Alterio, V, De Simone, G.
Deposit date:2007-04-27
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides-Solution and crystallographic studies.
Bioorg.Med.Chem.Lett., 17, 2007
1YDD
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BU of 1ydd by Molmil
STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
Descriptor: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Nair, S.K, Christianson, D.W.
Deposit date:1994-12-22
Release date:1995-02-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of inhibitor affinity to variants of human carbonic anhydrase II.
Biochemistry, 34, 1995
1YDB
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BU of 1ydb by Molmil
STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
Descriptor: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Nair, S.K, Christianson, D.W.
Deposit date:1994-12-22
Release date:1995-02-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of inhibitor affinity to variants of human carbonic anhydrase II.
Biochemistry, 34, 1995
2Q38
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BU of 2q38 by Molmil
Carbonic Anhydrase II in complex with Saccharin at 1.95 Angstrom
Descriptor: 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, BENZOIC ACID, Carbonic anhydrase 2, ...
Authors:Schulze Wischeler, J, Heine, A, Klebe, G.
Deposit date:2007-05-30
Release date:2007-10-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Saccharin Inhibits Carbonic Anhydrases: Possible Explanation for its Unpleasant Metallic Aftertaste.
Angew.Chem.Int.Ed.Engl., 46, 2007
1YO0
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BU of 1yo0 by Molmil
Proton Transfer from His200 in Human Carbonic Anhydrase II
Descriptor: CHLORIDE ION, Carbonic anhydrase II, ZINC ION
Authors:Bhatt, D, Tu, C, Fisher, S.Z, Hernandez Prada, J.A, McKenna, R, Silverman, D.N.
Deposit date:2005-01-26
Release date:2005-09-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Proton transfer in a Thr200His mutant of human carbonic anhydrase II
Proteins, 61, 2005
2POV
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BU of 2pov by Molmil
The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-chloro-benzene-1,3-disulfonamide
Descriptor: 4-AMINO-6-CHLOROBENZENE-1,3-DISULFONAMIDE, Carbonic anhydrase 2, ZINC ION
Authors:Alterio, V, De Simone, G.
Deposit date:2007-04-27
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides-Solution and crystallographic studies.
Bioorg.Med.Chem.Lett., 17, 2007
2POU
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BU of 2pou by Molmil
The crystal structure of the human carbonic anhydrase II in complex with 4,5-dichloro-benzene-1,3-disulfonamide
Descriptor: 4,5-DICHLOROBENZENE-1,3-DISULFONAMIDE, Carbonic anhydrase 2, ZINC ION
Authors:Alterio, V, De Simone, G.
Deposit date:2007-04-27
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides-Solution and crystallographic studies.
Bioorg.Med.Chem.Lett., 17, 2007
1YDC
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BU of 1ydc by Molmil
STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION
Authors:Nair, S.K, Christianson, D.W.
Deposit date:1994-12-22
Release date:1995-02-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis of inhibitor affinity to variants of human carbonic anhydrase II.
Biochemistry, 34, 1995
1ZFQ
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BU of 1zfq by Molmil
carbonic anhydrase II in complex with ethoxzolamidphenole as sulfonamide inhibitor
Descriptor: (4-CARBOXYPHENYL)(CHLORO)MERCURY, 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE, Carbonic anhydrase II, ...
Authors:Honndorf, V.S, Heine, A, Klebe, G, Supuran, C.T.
Deposit date:2005-04-20
Release date:2006-05-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:carbonic anhydrase II in complex with ethoxzolamidphenole as sulfonamide inhibitor
To be Published

222624

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