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7O6F	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-178 Descriptor: 14-3-3 protein sigma, 4-[4-(2-hydroxyethyl)piperidin-1-yl]carbonylbenzaldehyde, CALCIUM ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2021-04-11 Release date: 2021-06-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
6SLW	Fragment AZ-004 binding at the TAZpS89/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, WW domain-containing transcription regulator protein 1 Authors: Ottmann, C, Wolter, M, Guillory, X, Leysen, S, Genet, S, Somsen, B, Patel, J, Castaldi, P. Deposit date: 2019-08-20 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
7D8P	CRTC1 pSer151 peptide in complex with 14-3-3 zeta Descriptor: 14-3-3 protein zeta/delta, CRTC1 pSer151 peptide, GLYCEROL Authors: Chen, H, Zhang, H, Xiang, S. Deposit date: 2020-10-08 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
7OBH	Crystal structure of 14-3-3 sigma in complex with NPM1 phosphopeptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-22 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBD	Crystal structure of 14-3-3 sigma in complex with Phosphorylated and Farnesylated Rnd3 peptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FARNESYL, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-21 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
3O8I	Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule fragment Descriptor: 14-3-3 binding site peptide of RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein sigma, 6,6-dihydroxy-1-methoxyhexan-2-one Authors: Ottmann, C, Rose, R, Kaiser, M, Kuhenne, P. Deposit date: 2010-08-03 Release date: 2010-09-29 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling Mol.Cell.Biol., 30, 2010
4DAU	Structure of 14-3-3 sigma in complex with PADI6 14-3-3 binding motif I Descriptor: 14-3-3 protein sigma, Peptidylarginine Deiminase type VI Authors: Rose, R, Rose, M, Ottmann, C. Deposit date: 2012-01-13 Release date: 2012-06-13 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. J.Struct.Biol., 180, 2012
7BMC	Crystal structure of 14-3-3 sigma in complex with CIP2ApS904 peptide and stabilizing Fusicoccin A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-01-19 Release date: 2022-03-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3. Acs Chem.Biol., 17, 2022
1QJB	14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1) Descriptor: 14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE Authors: Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B. Deposit date: 1999-06-23 Release date: 1999-09-15 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding Mol.Cell, 4, 1999
1QJA	14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2) Descriptor: 14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE Authors: Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B. Deposit date: 1999-06-23 Release date: 1999-09-15 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding Mol.Cell, 4, 1999
3SMM	Crystal structure of human 14-3-3 sigma C38N/N166H in complex with task-3 peptide and stabilizer Fusicoccin J aglycone Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Fusicoccin J aglycone, ... Authors: Anders, C, Schumacher, B, Ottmann, C. Deposit date: 2011-06-28 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
7QIK	SARS-CoV-2 Nucleocapsid phosphopeptide 193-200 bound to human 14-3-3 sigma Descriptor: 14-3-3 protein sigma, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BROMIDE ION, ... Authors: Sluchanko, N.N, Tugaeva, K.V, Smith, J.L.R, Antson, A.A. Deposit date: 2021-12-15 Release date: 2021-12-29 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.01 Å) Cite: SARS-CoV-2 Nucleocapsid phosphopeptide 193-200 bound to human 14-3-3 sigma To Be Published
6YMO	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pS617 peptide Descriptor: 14-3-3 protein zeta/delta, 2-HYDROXYBENZOIC ACID, Glucocorticoid receptor, ... Authors: Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. Deposit date: 2020-04-09 Release date: 2021-03-24 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
6T5H	Human 14-3-3 sigma fused to the StARD1 peptide including phosphoserine-57 Descriptor: 14-3-3 protein sigma,Steroidogenic acute regulatory protein, mitochondrial, IMIDAZOLE, ... Authors: Sluchanko, N.N, Tugaeva, K.V, Titterington, J, Antson, A.A. Deposit date: 2019-10-16 Release date: 2020-11-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family. Febs J., 287, 2020
6YOX	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-027 Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2020-04-15 Release date: 2020-09-23 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
4JC3	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface Descriptor: 14-3-3 protein sigma, Estrogen receptor Peptide, MAGNESIUM ION Authors: Bier, D, Ottmann, C. Deposit date: 2013-02-21 Release date: 2013-05-15 Last modified: 2017-06-07 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
6YGJ	small-molecule stabilizer of 14-3-3 and the Carbohydrate Response Element Binding Protein (ChREBP) protein-protein interaction Descriptor: 14-3-3 protein beta/alpha, Carbohydrate-responsive element-binding protein, [2-[2-oxidanylidene-2-(2-phenylethylamino)ethoxy]phenyl]phosphonic acid Authors: Ottmann, C, Visser, E.J. Deposit date: 2020-03-27 Release date: 2020-09-16 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions. Nat Commun, 11, 2020
5NWJ	14-3-3c in complex with CPP7 Descriptor: 14-3-3-like protein C, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Saponaro, A, Porro, A, Chaves-Sanjuan, A, Nardini, M, Thiel, G, Moroni, A. Deposit date: 2017-05-06 Release date: 2017-11-22 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins. Plant Cell, 29, 2017
3EFZ	Crystal Structure of a 14-3-3 protein from cryptosporidium parvum (cgd1_2980) Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein Authors: Wernimont, A.K, Dong, A, Qiu, W, Lew, J, Wasney, G.A, Vedadi, M, Kozieradzki, I, Zhao, Y, Ren, H, Alam, Z, Lin, Y.H, Sundstrom, M, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Hui, R, Brokx, S, Structural Genomics Consortium (SGC) Deposit date: 2008-09-10 Release date: 2008-09-23 Last modified: 2012-02-22 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Characterization of 14-3-3 proteins from Cryptosporidium parvum. Plos One, 6, 2011
5NAS	Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide Descriptor: 14-3-3 protein zeta/delta, Phosphatidylinositol 4-kinase beta Authors: Boura, E, Eisenreichova, A. Deposit date: 2017-02-28 Release date: 2017-03-29 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide To Be Published
6YO8	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide Descriptor: 14-3-3 protein zeta/delta, Glucocorticoid receptor Authors: Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. Deposit date: 2020-04-14 Release date: 2021-03-24 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
6A5S	Structure of 14-3-3 gamma in complex with TFEB 14-3-3 binding motif Descriptor: 14-3-3 protein gamma, MAGNESIUM ION, SODIUM ION, ... Authors: Xu, Y, Ren, J.Q, Feng, W. Deposit date: 2018-06-25 Release date: 2019-02-13 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.099 Å) Cite: YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy, 15, 2019
8BWH	Small molecule stabilizer for 14-3-3/ChREBP (Cmd 42) Descriptor: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ... Authors: Pennings, M.A.M, Visser, E.J, Ottmann, C. Deposit date: 2022-12-06 Release date: 2024-05-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Biorxiv, 2024
3SMK	Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Cotylenin A Descriptor: 14-3-3 protein sigma, Cotylenin A, MAGNESIUM ION, ... Authors: Anders, C, Schumacher, B, Ottmann, C. Deposit date: 2011-06-28 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
5YQG	The structure of 14-3-3 and pNumb peptide Descriptor: 14-3-3 protein eta, Peptide from Protein numb homolog Authors: Chen, X, Liu, Z, Wen, W. Deposit date: 2017-11-06 Release date: 2018-02-07 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural determinants controlling 14-3-3 recruitment to the endocytic adaptor Numb and dissociation of the Numb/alpha-adaptin complex. J. Biol. Chem., 293, 2018

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