6VWA
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3WOB
| Crystal structure of a prostate-specific WGA16 glycoprotein lectin, form I | Descriptor: | hypothetical protein | Authors: | Garenaux, E, Kanagawa, M, Tsuchiyama, T, Hori, K, Kanazawa, T, Goshima, A, Chiba, M, Yasue, H, Ikeda, A, Yamaguchi, Y, Sato, C, Kitajima, K. | Deposit date: | 2013-12-26 | Release date: | 2014-12-31 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Discovery, Primary, and Crystal Structures and Capacitation-related Properties of a Prostate-derived Heparin-binding Protein WGA16 from Boar Sperm J.Biol.Chem., 290, 2015
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5U65
| Camel Nanobody VHH-5 | Descriptor: | SULFATE ION, VHH-5 | Authors: | Stanfield, R.L, Wilson, I.A. | Deposit date: | 2016-12-07 | Release date: | 2017-09-20 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers. Sci Rep, 7, 2017
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2F1G
| Cathepsin S in complex with non-covalent 2-(Benzoxazol-2-ylamino)-acetamide | Descriptor: | Cathepsin S, GLYCEROL, N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDE | Authors: | Spraggon, G, Hornsby, M, Lesley, S.A, Tully, D.C, Harris, J.L, Karenewsky, D.S, Kulathila, R, Clark, K. | Deposit date: | 2005-11-14 | Release date: | 2006-04-04 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: Heterocyclic P3. Bioorg.Med.Chem.Lett., 16, 2006
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3WOC
| Crystal structure of a prostate-specific WGA16 glycoprotein lectin, form II | Descriptor: | 1,4-DIETHYLENE DIOXIDE, GLYCEROL, SULFATE ION, ... | Authors: | Garenaux, E, Kanagawa, M, Tsuchiyama, T, Hori, K, Kanazawa, T, Goshima, A, Chiba, M, Yasue, H, Ikeda, A, Yamaguchi, Y, Sato, C, Kitajima, K. | Deposit date: | 2013-12-26 | Release date: | 2014-12-31 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Discovery, Primary, and Crystal Structures and Capacitation-related Properties of a Prostate-derived Heparin-binding Protein WGA16 from Boar Sperm J.Biol.Chem., 290, 2015
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5C3I
| Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2 | Descriptor: | DNA replication licensing factor MCM2,MCM2, Histone H3.1, Histone H4, ... | Authors: | Wang, H, Wang, M, Yang, N, Xu, R.M. | Deposit date: | 2015-06-17 | Release date: | 2015-07-29 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2 Protein Cell, 6, 2015
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5E0O
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7ZBF
| Crystal structure of native Iripin-4 serpin from tick Ixodes ricinus | Descriptor: | Iripin-4 serpin, NICKEL (II) ION | Authors: | Kascakova, B, Kuta Smatanova, I, Chmelar, J, Prudnikova, T. | Deposit date: | 2022-03-23 | Release date: | 2023-04-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Conformational transition of the Ixodes ricinus salivary serpin Iripin-4. Acta Crystallogr D Struct Biol, 79, 2023
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2CVX
| Structures of Yeast Ribonucleotide Reductase I | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. | Deposit date: | 2005-06-14 | Release date: | 2006-03-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
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8T55
| Co-crystal structure of the WD-repeat domain of human WDR91 in complex with MR46654 | Descriptor: | 1,2-ETHANEDIOL, N-[3-(4-chlorophenyl)oxetan-3-yl]-1-propanoyl-1,2,3,4-tetrahydroquinoline-5-carboxamide, WD repeat-containing protein 91 | Authors: | Ahmad, H, Zeng, H, Dong, A, Li, Y, Yen, H, Seitova, A, Xu, J, Feng, J.W, Brown, P.J, Santhakumar, V, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | Deposit date: | 2023-06-12 | Release date: | 2023-07-05 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning. J.Med.Chem., 66, 2023
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8SHJ
| Crystal structure of the WD-repeat domain of human WDR91 in complex with MR45279 | Descriptor: | N-[3-(4-chlorophenyl)oxetan-3-yl]-4-[(3S)-3-hydroxypyrrolidin-1-yl]benzamide, WD repeat-containing protein 91 | Authors: | Ahmad, H, Zeng, H, Dong, A, Li, Y, Hutchinson, A, Seitova, A, Xu, J, Feng, J.W, Brown, P.J, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | Deposit date: | 2023-04-14 | Release date: | 2023-07-05 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning. J.Med.Chem., 66, 2023
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7BDV
| Structure of Can2 from Sulfobacillus thermosulfidooxidans in complex with cyclic tetra-adenylate (cA4) | Descriptor: | Can2, Cyclic tetraadenosine monophosphate (cA4) | Authors: | McQuarrie, S, McMahon, S.A, Gloster, T.M, White, M.F, Graham, S, Zhu, W, Gruschow, S. | Deposit date: | 2020-12-22 | Release date: | 2021-03-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence. Nucleic Acids Res., 49, 2021
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8EV5
| NlpC B3 covalently bound with E64 inhibitor fragment | Descriptor: | Clan CA, family C40, NlpC/P60 superfamily cysteine peptidase, ... | Authors: | Barnett, M.J, Goldstone, D.C. | Deposit date: | 2022-10-19 | Release date: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | NlpC/P60 peptidoglycan hydrolases of Trichomonas vaginalis have complementary activities that empower the protozoan to control host-protective lactobacilli. Plos Pathog., 19, 2023
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5KWE
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5BK9
| AAD-1 Bound to the Vanadyl Ion and Succinate | Descriptor: | (R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase, PHOSPHATE ION, SUCCINIC ACID, ... | Authors: | Ongpipattanakul, C, Chekan, J.R. | Deposit date: | 2019-06-01 | Release date: | 2019-06-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Molecular basis for enantioselective herbicide degradation imparted by aryloxyalkanoate dioxygenases in transgenic plants. Proc.Natl.Acad.Sci.USA, 116, 2019
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6H5H
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6HIX
| Cryo-EM structure of the Trypanosoma brucei mitochondrial ribosome - This entry contains the large mitoribosomal subunit | Descriptor: | 12S rRNA, 50S ribosomal protein L13, putative, ... | Authors: | Ramrath, D.J.F, Niemann, M, Leibundgut, M, Bieri, P, Prange, C, Horn, K, Leitner, A, Boehringer, D, Schneider, A, Ban, N. | Deposit date: | 2018-08-31 | Release date: | 2018-09-26 | Last modified: | 2019-02-06 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes. Science, 362, 2018
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4GR6
| Crystal structure of AtRbcX2 from Arabidopsis thaliana | Descriptor: | 1,2-ETHANEDIOL, AtRbcX2 | Authors: | Grudnik, P, Golik, P, Kolesinski, P, Dubin, G, Szczepaniak, A. | Deposit date: | 2012-08-24 | Release date: | 2013-01-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Insights into eukaryotic Rubisco assembly - Crystal structures of RbcX chaperones from Arabidopsis thaliana. Biochim.Biophys.Acta, 1830, 2013
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6U6Z
| Human SAMHD1 bound to deoxyribo(TG*TTCA)-oligonucleotide | Descriptor: | DNA polymer TG(PST)TCA, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ZINC ION | Authors: | Taylor, A.B, Yu, C.H, Ivanov, D.N. | Deposit date: | 2019-08-30 | Release date: | 2020-09-02 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification. Nat Commun, 12, 2021
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5LWJ
| Solution NMR structure of the GTP binding Class II RNA aptamer-ligand-complex containing a protonated adenine nucleotide with a highly shifted pKa. | Descriptor: | GTP Class II RNA (34-MER), GUANOSINE-5'-TRIPHOSPHATE | Authors: | Wolter, A.C, Weickhmann, A.K, Nasiri, A.H, Hantke, K, Ohlenschlaeger, O, Wunderlich, C.H, Kreutz, C, Duchardt-Ferner, E, Woehnert, J. | Deposit date: | 2016-09-17 | Release date: | 2016-12-14 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | A Stably Protonated Adenine Nucleotide with a Highly Shifted pKa Value Stabilizes the Tertiary Structure of a GTP-Binding RNA Aptamer. Angew. Chem. Int. Ed. Engl., 56, 2017
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5M00
| Crystal structure of murine P14 TCR complex with H-2Db and Y4A, modified gp33 peptide from LCMV | Descriptor: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, D-B alpha chain, ... | Authors: | Achour, A, Sandalova, T, Sun, R, Han, X. | Deposit date: | 2016-10-03 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Thernary complexes of TCR P14 give insights into the mechanisms behind reestablishment of CTL responses against a viral escape mutant To Be Published
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8FUR
| Crystal structure of human IDO1 with compound 11 | Descriptor: | Indoleamine 2,3-dioxygenase 1, N-(4-methylphenyl)-N'-[(1P,2'P)-4-propoxy-5-propyl-2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]urea | Authors: | Critton, D.A, Lewis, H.A. | Deposit date: | 2023-01-18 | Release date: | 2023-04-26 | Last modified: | 2023-05-03 | Method: | X-RAY DIFFRACTION (2.285 Å) | Cite: | Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1. Bioorg.Med.Chem.Lett., 88, 2023
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8IZF
| Cryo-EM structure of the Lac1-Lip1 (Lip1-S74F) complex | Descriptor: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Ceramide synthase LAC1, Ceramide synthase subunit LIP1 | Authors: | Xie, T, Fang, Q, Gong, X. | Deposit date: | 2023-04-07 | Release date: | 2023-12-13 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.85 Å) | Cite: | Structure and mechanism of a eukaryotic ceramide synthase complex. Embo J., 42, 2023
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8IZD
| Cryo-EM structure of the C26-CoA-bound Lac1-Lip1 complex | Descriptor: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Ceramide synthase LAC1, Ceramide synthase subunit LIP1, ... | Authors: | Xie, T, Fang, Q, Gong, X. | Deposit date: | 2023-04-07 | Release date: | 2023-12-13 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Structure and mechanism of a eukaryotic ceramide synthase complex. Embo J., 42, 2023
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7C5D
| Crystal structure of TRF2 TRFH domain in complex with a MCPH1 peptide | Descriptor: | GLYCEROL, Microcephalin, Telomeric repeat-binding factor 2 | Authors: | Xiong, X, Chen, Y. | Deposit date: | 2020-05-19 | Release date: | 2020-10-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.151 Å) | Cite: | Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly. Nat Commun, 11, 2020
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