7C5D

Crystal structure of TRF2 TRFH domain in complex with a MCPH1 peptide

Summary for 7C5D

• Entry DOI: 10.2210/pdb7c5d/pdb
• Descriptor: Telomeric repeat-binding factor 2, Microcephalin, GLYCEROL, ... (4 entities in total)
• Functional Keywords: telomere, shelterin complex, trf2, mcph1, dna repair, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 52492.76

Authors

Xiong, X.,Chen, Y. (deposition date: 2020-05-19, release date: 2020-10-21, Last modification date: 2023-11-29)

• Primary citation: Cicconi, A.,Rai, R.,Xiong, X.,Broton, C.,Al-Hiyasat, A.,Hu, C.,Dong, S.,Sun, W.,Garbarino, J.,Bindra, R.S.,Schildkraut, C.,Chen, Y.,Chang, S.; Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly.; Nat Commun, 11:5861-5861, 2020; PubMed: 33203878; DOI: 10.1038/s41467-020-19674-0

Experimental method

X-RAY DIFFRACTION (2.151 Å)