6U6Z

Human SAMHD1 bound to deoxyribo(TG*TTCA)-oligonucleotide

Summary for 6U6Z

• Entry DOI: 10.2210/pdb6u6z/pdb
• Descriptor: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, DNA polymer TG(PST)TCA, ZINC ION, ... (4 entities in total)
• Functional Keywords: samhd1, hiv, restriction factor, innate immunity, dntpase, deoxyribo-oligonucleotide, phosphorothioate, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 254644.51

Authors

Taylor, A.B.,Yu, C.H.,Ivanov, D.N. (deposition date: 2019-08-30, release date: 2020-09-02, Last modification date: 2023-10-11)

• Primary citation: Yu, C.H.,Bhattacharya, A.,Persaud, M.,Taylor, A.B.,Wang, Z.,Bulnes-Ramos, A.,Xu, J.,Selyutina, A.,Martinez-Lopez, A.,Cano, K.,Demeler, B.,Kim, B.,Hardies, S.C.,Diaz-Griffero, F.,Ivanov, D.N.; Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.; Nat Commun, 12:731-731, 2021; PubMed: 33531504; DOI: 10.1038/s41467-021-21023-8

Experimental method

X-RAY DIFFRACTION (2.1 Å)