6U6Z
Human SAMHD1 bound to deoxyribo(TG*TTCA)-oligonucleotide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | polymer | 535 | 61780.4 | 4 | UniProt (Q9Y3Z3) Pfam (PF01966) | Homo sapiens (Human) | dNTPase,Dendritic cell-derived IFNG-induced protein,DCIP,Monocyte protein 5,MOP-5,SAM domain and HD domain-containing protein 1,hSAMHD1 |
| 2 | E, F, G, H (E, F, H, G) | DNA polymer TG(PST)TCA | polymer | 6 | 1815.3 | 4 | synthetic construct | ||
| 3 | I, J, K, L (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 294 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 116 - 626 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Met 92 | - | initiating methionine |
| Trp 93 | - | expression tag |
| Ser 94 | - | expression tag |
| His 95 | - | expression tag |
| Pro 96 | - | expression tag |
| Gln 97 | - | expression tag |
| Phe 98 | - | expression tag |
| Glu 99 | - | expression tag |
| Lys 100 | - | expression tag |
| Gly 101 | - | expression tag |
| Ser 102 | - | expression tag |
| Gly 103 | - | expression tag |
| Ser 104 | - | expression tag |
| Glu 105 | - | expression tag |
| Asn 106 | - | expression tag |
| Leu 107 | - | expression tag |
| Tyr 108 | - | expression tag |
| Phe 109 | - | expression tag |
| Gln 110 | - | expression tag |
| Gly 111 | - | expression tag |
| Gly 112 | - | expression tag |
| Gly 113 | - | expression tag |
| Gly 114 | - | expression tag |
| Gly 115 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 254382.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 254644.5 |
