6U6Z

Human SAMHD1 bound to deoxyribo(TG*TTCA)-oligonucleotide

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN A 701

Chain	Residue
A	HIS167
A	HIS206
A	ASP207
A	ASP311
A	HOH811

---

site_id	AC2
Number of Residues	6
Details	binding site for residue ZN B 701

Chain	Residue
B	ASP311
B	HOH847
B	ARG164
B	HIS167
B	HIS206
B	ASP207

---

site_id	AC3
Number of Residues	5
Details	binding site for residue ZN C 701

Chain	Residue
C	HIS167
C	HIS206
C	ASP207
C	ASP311
C	HOH860

---

site_id	AC4
Number of Residues	5
Details	binding site for residue ZN D 701

Chain	Residue
D	HIS167
D	HIS206
D	ASP207
D	ASP311
D	HOH844

---

site_id	AC5
Number of Residues	14
Details	binding site for Di-nucleotide DG E 703 and PST E 704

Chain	Residue
A	TYR155
A	VAL156
A	HIS376
A	ARG451
A	LEU453
D	LYS116
D	VAL117
D	ASP137
D	GLN142
D	ARG145
D	PHE165
E	DT702
E	DT705
E	HOH801

---

site_id	AC6
Number of Residues	5
Details	binding site for Di-nucleotide PST E 704 and DT E 705

Chain	Residue
A	HIS376
D	VAL117
D	HIS125
E	DG703
E	HOH801

---

site_id	AC7
Number of Residues	16
Details	binding site for Di-nucleotide DG F 703 and PST F 704

Chain	Residue
B	TYR155
B	VAL156
B	HIS376
B	ARG451
B	LEU453
C	LYS116
C	VAL117
C	ILE118
C	ILE136
C	ASP137
C	GLN142
C	ARG145
C	PHE165
F	DT702
F	DT705
F	HOH801

---

site_id	AC8
Number of Residues	6
Details	binding site for Di-nucleotide PST F 704 and DT F 705

Chain	Residue
B	ARG372
B	HIS376
C	VAL117
C	HIS125
F	DG703
F	HOH801

---

site_id	AC9
Number of Residues	15
Details	binding site for Di-nucleotide DG G 704 and PST G 705

Chain	Residue
B	LYS116
B	VAL117
B	ILE118
B	ASP137
B	GLN142
B	ARG145
B	PHE165
C	TYR155
C	VAL156
C	HIS376
C	ARG451
C	LEU453
G	DT702
G	DT705
G	HOH801

---

site_id	AD1
Number of Residues	5
Details	binding site for Di-nucleotide PST G 705 and DT G 706

Chain	Residue
B	VAL117
B	HIS125
C	HIS376
G	DG703
G	HOH801

---

site_id	AD2
Number of Residues	15
Details	binding site for Di-nucleotide DG H 704 and PST H 705

Chain	Residue
A	LYS116
A	VAL117
A	ILE136
A	ASP137
A	GLN142
A	ARG145
A	PHE165
D	TYR155
D	VAL156
D	HIS376
D	ARG451
D	LEU453
H	DT702
H	DT705
H	HOH801

---

site_id	AD3
Number of Residues	4
Details	binding site for Di-nucleotide PST H 705 and DT H 706

Chain	Residue
D	HIS376
H	DG703
A	VAL117
A	HIS125

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"22056990","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24141705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BZB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	Binding site: {"description":"in chain C","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"24141705","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Binding site: {"description":"in chain C","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	16
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---