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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6U6Z

Human SAMHD1 bound to deoxyribo(TG*TTCA)-oligonucleotide

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN A 701

Chain	Residue
A	HIS167
A	HIS206
A	ASP207
A	ASP311
A	HOH811

site_id	AC2
Number of Residues	6
Details	binding site for residue ZN B 701

Chain	Residue
B	ASP311
B	HOH847
B	ARG164
B	HIS167
B	HIS206
B	ASP207

site_id	AC3
Number of Residues	5
Details	binding site for residue ZN C 701

Chain	Residue
C	HIS167
C	HIS206
C	ASP207
C	ASP311
C	HOH860

site_id	AC4
Number of Residues	5
Details	binding site for residue ZN D 701

Chain	Residue
D	HIS167
D	HIS206
D	ASP207
D	ASP311
D	HOH844

site_id	AC5
Number of Residues	14
Details	binding site for Di-nucleotide DG E 703 and PST E 704

Chain	Residue
A	TYR155
A	VAL156
A	HIS376
A	ARG451
A	LEU453
D	LYS116
D	VAL117
D	ASP137
D	GLN142
D	ARG145
D	PHE165
E	DT702
E	DT705
E	HOH801

site_id	AC6
Number of Residues	5
Details	binding site for Di-nucleotide PST E 704 and DT E 705

Chain	Residue
A	HIS376
D	VAL117
D	HIS125
E	DG703
E	HOH801

site_id	AC7
Number of Residues	16
Details	binding site for Di-nucleotide DG F 703 and PST F 704

Chain	Residue
B	TYR155
B	VAL156
B	HIS376
B	ARG451
B	LEU453
C	LYS116
C	VAL117
C	ILE118
C	ILE136
C	ASP137
C	GLN142
C	ARG145
C	PHE165
F	DT702
F	DT705
F	HOH801

site_id	AC8
Number of Residues	6
Details	binding site for Di-nucleotide PST F 704 and DT F 705

Chain	Residue
B	ARG372
B	HIS376
C	VAL117
C	HIS125
F	DG703
F	HOH801

site_id	AC9
Number of Residues	15
Details	binding site for Di-nucleotide DG G 704 and PST G 705

Chain	Residue
B	LYS116
B	VAL117
B	ILE118
B	ASP137
B	GLN142
B	ARG145
B	PHE165
C	TYR155
C	VAL156
C	HIS376
C	ARG451
C	LEU453
G	DT702
G	DT705
G	HOH801

site_id	AD1
Number of Residues	5
Details	binding site for Di-nucleotide PST G 705 and DT G 706

Chain	Residue
B	VAL117
B	HIS125
C	HIS376
G	DG703
G	HOH801

site_id	AD2
Number of Residues	15
Details	binding site for Di-nucleotide DG H 704 and PST H 705

Chain	Residue
A	LYS116
A	VAL117
A	ILE136
A	ASP137
A	GLN142
A	ARG145
A	PHE165
D	TYR155
D	VAL156
D	HIS376
D	ARG451
D	LEU453
H	DT702
H	DT705
H	HOH801

site_id	AD3
Number of Residues	4
Details	binding site for Di-nucleotide PST H 705 and DT H 706

Chain	Residue
D	HIS376
H	DG703
A	VAL117
A	HIS125

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000305\|PubMed:22056990

Chain	Residue	Details
A	HIS233
B	HIS233
C	HIS233
D	HIS233

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: in other chain => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200

Chain	Residue	Details
A	LYS116
B	ARG352
B	ASN358
B	LYS523
C	LYS116
C	ASP137
C	ARG333
C	ARG352
C	ASN358
C	LYS523
D	LYS116
A	ASP137
D	ASP137
D	ARG333
D	ARG352
D	ASN358
D	LYS523
A	ARG333
A	ARG352
A	ASN358
A	LYS523
B	LYS116
B	ASP137
B	ARG333

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25267621, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200

Chain	Residue	Details
A	ASN119
B	LYS455
C	ASN119
C	HIS376
C	LYS377
C	ARG451
C	LYS455
D	ASN119
D	HIS376
D	LYS377
D	ARG451
A	HIS376
D	LYS455
A	LYS377
A	ARG451
A	LYS455
B	ASN119
B	HIS376
B	LYS377
B	ARG451

site_id	SWS_FT_FI4
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269\|PubMed:24141705

Chain	Residue	Details
A	GLN149
B	ARG164
B	HIS210
B	ASP309
B	TYR315
B	ASP319
B	ARG366
B	HIS370
C	GLN149
C	ARG164
C	HIS210
A	ARG164
C	ASP309
C	TYR315
C	ASP319
C	ARG366
C	HIS370
D	GLN149
D	ARG164
D	HIS210
D	ASP309
D	TYR315
A	HIS210
D	ASP319
D	ARG366
D	HIS370
A	ASP309
A	TYR315
A	ASP319
A	ARG366
A	HIS370
B	GLN149

site_id	SWS_FT_FI5
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:24141705, ECO:0000269\|PubMed:24217394, ECO:0000269\|PubMed:25288794, ECO:0000269\|PubMed:25760601, ECO:0000269\|PubMed:26431200

Chain	Residue	Details
A	HIS167
C	HIS206
C	ASP207
C	ASP311
D	HIS167
D	HIS206
D	ASP207
D	ASP311
A	HIS206
A	ASP207
A	ASP311
B	HIS167
B	HIS206
B	ASP207
B	ASP311
C	HIS167

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by CDK1 => ECO:0000269\|PubMed:23601106, ECO:0000269\|PubMed:23602554, ECO:0000269\|PubMed:26294762, ECO:0000269\|PubMed:26431200, ECO:0000269\|PubMed:29610582, ECO:0000269\|PubMed:29670289, ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:19369195, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	THR592
B	THR592
C	THR592
D	THR592

site_id	SWS_FT_FI7
Number of Residues	20
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS467
B	LYS622
C	LYS467
C	LYS469
C	LYS492
C	LYS622
D	LYS467
D	LYS469
D	LYS492
D	LYS622
A	LYS469
A	LYS492
A	LYS622
B	LYS467
B	LYS469
B	LYS492

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PDB entries from 2024-07-24

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