7D43
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![BU of 7d43 by Molmil](/molmil-images/mine/7d43) | eIF2B-eIF2(aP), aPg complex | Descriptor: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 subunit 3, ... | Authors: | Kashiwagi, K, Ito, T. | Deposit date: | 2020-09-22 | Release date: | 2020-12-09 | Last modified: | 2021-01-27 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B. Mol.Cell, 81, 2021
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7M40
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![BU of 7m40 by Molmil](/molmil-images/mine/7m40) | Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4) | Descriptor: | Histone-binding protein RBBP4, N~3~-{4-[3-(dimethylamino)pyrrolidin-1-yl]-6,7-dimethoxyquinazolin-2-yl}-N~1~,N~1~-dimethylpropane-1,3-diamine | Authors: | Perveen, S, Dong, A, Tempel, W, Zepeda-Velazquez, C, Abbey, M, McLeod, D, Marcellus, R, Mohammed, M, Ensan, D, Panagopoulos, D, Trush, V, Gibson, E, Brown, P.J, Arrowsmith, C.H, Schapira, M, Al-awar, R, Vedadi, M, Structural Genomics Consortium (SGC) | Deposit date: | 2021-03-19 | Release date: | 2021-05-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4) To Be Published
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2MQL
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![BU of 2mql by Molmil](/molmil-images/mine/2mql) | Structural Investigation of hnRNP L | Descriptor: | Protein Hnrnpl | Authors: | Blatter, M, Allain, F. | Deposit date: | 2014-06-24 | Release date: | 2015-05-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Signature of the Five-Stranded vRRM Fold Defined by Functional, Structural and Computational Analysis of the hnRNP L Protein. J.Mol.Biol., 427, 2015
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2MQO
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7DNO
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![BU of 7dno by Molmil](/molmil-images/mine/7dno) | Characterization of Peptide Ligands Against WDR5 Isolated Using Phage Display Technique | Descriptor: | CYS-ARG-THR-LEU-PRO-PHE, WD repeat-containing protein 5 | Authors: | Cao, J, Cao, D, Xiong, B, Li, Y, Fan, T. | Deposit date: | 2020-12-10 | Release date: | 2021-02-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Phage-Display Based Discovery and Characterization of Peptide Ligands against WDR5. Molecules, 26, 2021
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2MVW
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![BU of 2mvw by Molmil](/molmil-images/mine/2mvw) | Solution structure of the TRIM19 B-box1 (B1) of human promyelocytic leukemia (PML) | Descriptor: | Protein PML, ZINC ION | Authors: | Huang, S, Naik, M.T, Fan, P, Wang, Y, Chang, C, Huang, T. | Deposit date: | 2014-10-17 | Release date: | 2014-11-12 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The B-box 1 dimer of human promyelocytic leukemia protein. J.Biomol.Nmr, 60, 2014
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5HSV
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![BU of 5hsv by Molmil](/molmil-images/mine/5hsv) | X-Ray structure of a CypA-Alisporivir complex at 1.5 angstrom resolution | Descriptor: | Alisporivir, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase A | Authors: | Dujardin, M, Bouckaert, J, Rucktooa, P, Hanoulle, X. | Deposit date: | 2016-01-26 | Release date: | 2017-08-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | X-ray structure of alisporivir in complex with cyclophilin A at 1.5 angstrom resolution. Acta Crystallogr F Struct Biol Commun, 74, 2018
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7LU5
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![BU of 7lu5 by Molmil](/molmil-images/mine/7lu5) | SAMHD1(113-626) H206R D207N R366H | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | Authors: | Temple, J.T, Bowen, N.E. | Deposit date: | 2021-02-20 | Release date: | 2021-11-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.57 Å) | Cite: | Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins. J.Biol.Chem., 297, 2021
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7LTT
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![BU of 7ltt by Molmil](/molmil-images/mine/7ltt) | SAMHD1(113-626) H206R D207N R366C | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, MAGNESIUM ION | Authors: | Temple, J.T, Bowen, N.E. | Deposit date: | 2021-02-20 | Release date: | 2021-11-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins. J.Biol.Chem., 297, 2021
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2MZN
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2N1U
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![BU of 2n1u by Molmil](/molmil-images/mine/2n1u) | Structure of SAP30L corepressor protein | Descriptor: | Histone deacetylase complex subunit SAP30L, ZINC ION | Authors: | Tossavainen, H, Permi, P. | Deposit date: | 2015-04-23 | Release date: | 2015-11-25 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Redox-dependent disulfide bond formation in SAP30L corepressor protein: Implications for structure and function. Protein Sci., 25, 2016
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5HA9
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![BU of 5ha9 by Molmil](/molmil-images/mine/5ha9) | Crystal structure-based design and disovery of a novel PARP1 antiagonist (BL-PA10) that induces apoptosis and inhibits metastasis in triple negative breast cancer | Descriptor: | Amitriptyline, GLYCEROL, Poly [ADP-ribose] polymerase 1, ... | Authors: | Fu, L, Peng, H, Zhang, L, Ouyang, L. | Deposit date: | 2015-12-30 | Release date: | 2016-03-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (4.01 Å) | Cite: | Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer. Sci Rep, 6, 2016
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2MXC
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![BU of 2mxc by Molmil](/molmil-images/mine/2mxc) | Solution structure of the full length sorting nexin 3 | Descriptor: | Sorting nexin-3 | Authors: | Lenoir, M.M.L, Rajesh, S.S.R, Gruenberg, J.J.G, Overduin, M.M.O, Kaur, J.J.K. | Deposit date: | 2014-12-20 | Release date: | 2016-05-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting. Nat Commun, 9, 2018
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7LA9
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5HXB
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![BU of 5hxb by Molmil](/molmil-images/mine/5hxb) | Cereblon in complex with DDB1, CC-885, and GSPT1 | Descriptor: | 1-(3-chloro-4-methylphenyl)-3-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)urea, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ... | Authors: | Chamberlain, P.P, Matyskiela, M, Pagarigan, B. | Deposit date: | 2016-01-30 | Release date: | 2016-06-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Nature, 535, 2016
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2MQN
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![BU of 2mqn by Molmil](/molmil-images/mine/2mqn) | Structural Investigation of hnRNP L | Descriptor: | Heterogenous nuclear ribonucleoprotein L | Authors: | Blatter, M, Allain, F. | Deposit date: | 2014-06-24 | Release date: | 2015-05-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Signature of the Five-Stranded vRRM Fold Defined by Functional, Structural and Computational Analysis of the hnRNP L Protein. J.Mol.Biol., 427, 2015
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7DCT
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![BU of 7dct by Molmil](/molmil-images/mine/7dct) | Crystal structure of HSF1 DNA-binding domain in complex with 3-site HSE DNA (24 bp) | Descriptor: | DNA (5'-D(*AP*CP*TP*CP*GP*CP*GP*AP*AP*TP*AP*TP*TP*CP*TP*AP*GP*AP*AP*CP*GP*CP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*GP*CP*GP*TP*TP*CP*TP*AP*GP*AP*AP*TP*AP*TP*TP*CP*GP*CP*GP*AP*G)-3'), Heat shock factor protein 1, ... | Authors: | Feng, N, Liu, W. | Deposit date: | 2020-10-27 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Structures of heat shock factor trimers bound to DNA. Iscience, 24, 2021
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7DCJ
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7DCU
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![BU of 7dcu by Molmil](/molmil-images/mine/7dcu) | Crystal structure of HSF2 DNA-binding domain in complex with 3-site HSE DNA (21 bp) | Descriptor: | DNA (5'-D(*AP*CP*CP*GP*CP*GP*AP*AP*TP*AP*TP*TP*CP*TP*AP*GP*AP*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*TP*CP*TP*AP*GP*AP*AP*TP*AP*TP*TP*CP*GP*CP*GP*G)-3'), Heat shock factor protein 2, ... | Authors: | Feng, N, Liu, W. | Deposit date: | 2020-10-27 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structures of heat shock factor trimers bound to DNA. Iscience, 24, 2021
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7DCI
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7DCS
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![BU of 7dcs by Molmil](/molmil-images/mine/7dcs) | Crystal structure of HSF1 DNA-binding domain in complex with 3-site HSE DNA (23 bp) | Descriptor: | DNA (5'-D(*AP*TP*CP*CP*GP*CP*GP*AP*AP*TP*AP*TP*TP*CP*TP*AP*GP*AP*AP*CP*GP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*CP*GP*TP*TP*CP*TP*AP*GP*AP*AP*TP*AP*TP*TP*CP*GP*CP*GP*GP*A)-3'), Heat shock factor protein 1, ... | Authors: | Feng, N, Liu, W. | Deposit date: | 2020-10-27 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of heat shock factor trimers bound to DNA. Iscience, 24, 2021
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2MQQ
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2MWX
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![BU of 2mwx by Molmil](/molmil-images/mine/2mwx) | The RING Domain of human Promyelocytic Leukemia Protein (PML) | Descriptor: | Protein PML, ZINC ION | Authors: | Huang, S.Y, Chang, C.F, Fan, P.J, Guntert, P, Shih, H.M, Huang, T.H. | Deposit date: | 2014-12-02 | Release date: | 2015-02-11 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The RING domain of human promyelocytic leukemia protein (PML). J.Biomol.Nmr, 61, 2015
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7MCF
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![BU of 7mcf by Molmil](/molmil-images/mine/7mcf) | CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH 2-{3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-6-fluoro-5-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-5H-pyrido[3,2-b]indol-7-yl}propan-2-ol | Descriptor: | 2-{3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-6-fluoro-5-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-5H-pyrido[3,2-b]indol-7-yl}propan-2-ol, Bromodomain-containing protein 4 | Authors: | Sheriff, S. | Deposit date: | 2021-04-02 | Release date: | 2021-05-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Development of BET inhibitors as potential treatments for cancer: A search for structural diversity. Bioorg.Med.Chem.Lett., 44, 2021
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2N5N
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![BU of 2n5n by Molmil](/molmil-images/mine/2n5n) | Structure of an N-terminal domain of CHD4 | Descriptor: | Chromodomain-helicase-DNA-binding protein 4 | Authors: | Silva, A.P.G, Mackay, J.P. | Deposit date: | 2015-07-22 | Release date: | 2015-11-18 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose). J.Biol.Chem., 291, 2016
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