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6MU4
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BU of 6mu4 by Molmil
Bst DNA polymerase I FANA/DNA binary complex
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(P*GP*CP*GP*AP*TP*CP*AP*CP*GP*T)-3'), DNA polymerase I, ...
Authors:Jackson, L.N, Chim, N, Chaput, J.C.
Deposit date:2018-10-22
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase.
Nucleic Acids Res., 47, 2019
5YTE
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BU of 5yte by Molmil
Large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with with natural dT:dATP base pair
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*AP*TP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ...
Authors:Zeng, H, Mondal, M, Song, R.Y, Zhang, J, Xia, B, Gao, Y.Q, Yi, C.Q.
Deposit date:2017-11-17
Release date:2018-11-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry.
Angew. Chem. Int. Ed. Engl., 58, 2019
3GII
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BU of 3gii by Molmil
Dpo4 extension ternary complex with disordered A opposite an oxoG in anti conformation
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*AP*AP*CP*(8OG)P*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', 5'-D(*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*GP*(2DA))-3', ...
Authors:Rechkoblit, O, Malinina, L, Patel, D.J.
Deposit date:2009-03-05
Release date:2009-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases.
Structure, 17, 2009
3GIL
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BU of 3gil by Molmil
Dpo4 extension ternary complex with oxoG(anti)-T(anti) pair
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*AP*AP*CP*(8OG)P*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*C)-3', 5'-D(*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*GP*(2DT))-3', ...
Authors:Rechkoblit, O, Malinina, L, Patel, D.J.
Deposit date:2009-03-05
Release date:2009-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases.
Structure, 17, 2009
6MU5
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BU of 6mu5 by Molmil
Bst DNA polymerase I TNA/DNA binary complex
Descriptor: DNA (5'-D(P*GP*CP*GP*AP*TP*CP*AP*CP*GP*T)-3'), DNA polymerase I, SULFATE ION, ...
Authors:Jackson, L.N, Chim, N, Chaput, J.C.
Deposit date:2018-10-22
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.912 Å)
Cite:Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase.
Nucleic Acids Res., 47, 2019
5V0U
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BU of 5v0u by Molmil
Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to follow on fragment EBSI-4723 4-(5-chlorothiophen-2-yl)-1H-pyrazole
Descriptor: 4-(5-chlorothiophen-2-yl)-1H-pyrazole, Polymerase acidic protein
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-02-28
Release date:2017-03-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase
To Be Published
1AV6
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BU of 1av6 by Molmil
VACCINIA METHYLTRANSFERASE VP39 COMPLEXED WITH M7G CAPPED RNA HEXAMER AND S-ADENOSYLHOMOCYSTEINE
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, RNA (5'-R(*GP*AP*AP*AP*AP*A)-3'), ...
Authors:Hodel, A.E, Gershon, P.D, Quiocho, F.A.
Deposit date:1997-09-26
Release date:1998-02-25
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for sequence-nonspecific recognition of 5'-capped mRNA by a cap-modifying enzyme.
Mol.Cell, 1, 1998
1TLH
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BU of 1tlh by Molmil
T4 AsiA bound to sigma70 region 4
Descriptor: 10 kDa anti-sigma factor, RNA polymerase sigma factor rpoD
Authors:Lambert, L.J, Wei, Y, Schirf, V, Demeler, B, Werner, M.H.
Deposit date:2004-06-09
Release date:2004-11-23
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:T4 AsiA blocks DNA recognition by remodeling sigma(70) region 4
Embo J., 23, 2004
2I9G
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BU of 2i9g by Molmil
DNA Polymerase Beta with a Benzo[c]phenanthrene diol epoxide adducted guanine base
Descriptor: (1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL, 5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', ...
Authors:Batra, V.K, Wilson, S.H, Beard, W.A, Pedersen, L.C.
Deposit date:2006-09-05
Release date:2006-10-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features.
Proc.Natl.Acad.Sci.Usa, 103, 2006
6WW6
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BU of 6ww6 by Molmil
Crystal structure of EutV bound to RNA
Descriptor: BERYLLIUM TRIFLUORIDE ION, Response regulator, eutP P2
Authors:Ataide, S.F, Walshe, J.L.
Deposit date:2020-05-07
Release date:2021-11-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural characterization of the ANTAR antiterminator domain bound to RNA.
Nucleic Acids Res., 50, 2022
1HWQ
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BU of 1hwq by Molmil
SOLUTION STRUCTURE OF THE VS RIBOZYME SUBSTRATE STEM-LOOP
Descriptor: VS RIBOZYME SUBSTRATE RNA
Authors:Flinders, J.C, Dieckmann, T.
Deposit date:2001-01-09
Release date:2001-05-16
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:A pH controlled conformational switch in the cleavage site of the VS ribozyme substrate RNA.
J.Mol.Biol., 308, 2001
2P40
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BU of 2p40 by Molmil
Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppG
Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, SULFATE ION, type II methyltransferase
Authors:Egloff, M.P, Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2007-03-11
Release date:2007-08-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
J.Mol.Biol., 372, 2007
1UUI
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BU of 1uui by Molmil
NMR structure of a synthetic small molecule, rbt158, bound to HIV-1 TAR RNA
Descriptor: 4-[AMINO(IMINO)METHYL]-1-[2-(3-AMMONIOPROPOXY)-5-METHOXYBENZYL]PIPERAZIN-1-IUM, 5'-R(*GP*GP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP*CP* CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*UP*CP*UP*GP*CP*C)-3'
Authors:Davis, B, Afshar, M, Varani, G, Karn, J, Murchie, A.I.H, Lentzen, G, Drysdale, M.J, Potter, A.J, Bower, J, Aboul-Ela, F.
Deposit date:2003-12-19
Release date:2004-02-12
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Rational Design of Inhibitors of HIV-1 Tar RNA Through the Stabilisation of Electrostatic "Hot Spots"
J.Mol.Biol., 336, 2004
3FBN
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BU of 3fbn by Molmil
Structure of the Mediator submodule Med7N/31
Descriptor: Mediator of RNA polymerase II transcription subunit 31, Mediator of RNA polymerase II transcription subunit 7
Authors:Koschubs, T, Seizl, M, Lariviere, L, Kurth, F, Baumli, S, Martin, D.E, Cramer, P.
Deposit date:2008-11-19
Release date:2008-12-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.007 Å)
Cite:Identification, structure, and functional requirement of the Mediator submodule Med7N/31
Embo J., 28, 2009
5V5H
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BU of 5v5h by Molmil
OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.2
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, RNA-directed RNA polymerase L, SODIUM ION, ...
Authors:Khare, B, Mark, B.L.
Deposit date:2017-03-14
Release date:2017-05-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.
PLoS Pathog., 13, 2017
1K6O
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BU of 1k6o by Molmil
Crystal Structure of a Ternary SAP-1/SRF/c-fos SRE DNA Complex
Descriptor: 5'-D(*CP*AP*CP*AP*GP*GP*AP*TP*GP*TP*CP*CP*AP*TP*AP*TP*TP*AP*GP*GP*AP*CP*A)-3', 5'-D(*TP*GP*TP*CP*CP*TP*AP*AP*TP*AP*TP*GP*GP*AP*CP*AP*TP*CP*CP*TP*GP*TP*G)-3', ETS-domain protein ELK-4, ...
Authors:Mo, Y, Ho, W, Johnston, K, Marmorstein, R.
Deposit date:2001-10-16
Release date:2002-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex.
J.Mol.Biol., 314, 2001
7U72
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BU of 7u72 by Molmil
Human DNA polymerase eta-DNA ternary mismatch complex:ground state at pH7.0 (K+ MES) with 1 Ca2+ ion
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Chang, C, Gao, Y.
Deposit date:2022-03-07
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
Nat Commun, 13, 2022
7U76
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BU of 7u76 by Molmil
Human DNA polymerase eta-DNA ternary mismatch complex:reaction with 0.5 mM Mn2+ for 1800s then with 10 mM Mn2+ for 300s
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*TP*())-3'), ...
Authors:Chang, C, Gao, Y.
Deposit date:2022-03-07
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
Nat Commun, 13, 2022
7U7C
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BU of 7u7c by Molmil
Human DNA polymerase eta-DNA ternary mismatch complex:reaction with 1.0 mM Mg2+ for 300s
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*TP*G)-3'), ...
Authors:Chang, C, Gao, Y.
Deposit date:2022-03-07
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
Nat Commun, 13, 2022
7U7J
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BU of 7u7j by Molmil
Human DNA polymerase eta-DNA ternary mismatch complex:reaction with 10.0 mM Mn2+ for 300s
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*TP*G)-3'), ...
Authors:Chang, C, Gao, Y.
Deposit date:2022-03-07
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
Nat Commun, 13, 2022
7U7W
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BU of 7u7w by Molmil
Human DNA polymerase eta-DNA-dGMPNPP ternary mismatch complex in 1.0 mM Mg2+ for 600s
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
Authors:Chang, C, Gao, Y.
Deposit date:2022-03-07
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
Nat Commun, 13, 2022
7U7A
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BU of 7u7a by Molmil
Human DNA polymerase eta-DNA ternary mismatch complex:reaction with 1.0 mM Mg2+ for 200s
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*TP*G)-3'), ...
Authors:Chang, C, Gao, Y.
Deposit date:2022-03-07
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
Nat Commun, 13, 2022
7U78
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BU of 7u78 by Molmil
Human DNA polymerase eta-DNA ternary mismatch complex:reaction with 1.0 mM Mg2+ for 80s
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*TP*G)-3'), ...
Authors:Chang, C, Gao, Y.
Deposit date:2022-03-07
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
Nat Commun, 13, 2022
7U7F
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BU of 7u7f by Molmil
Human DNA polymerase eta-DNA ternary mismatch complex:reaction with 10.0 mM Mn2+ for 90s
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*TP*G)-3'), ...
Authors:Chang, C, Gao, Y.
Deposit date:2022-03-07
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
Nat Commun, 13, 2022
7U75
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BU of 7u75 by Molmil
Human DNA polymerase eta-DNA ternary mismatch complex:reaction with 0.5 mM Mn2+ for 1800s then with 10 mM Mn2+ for 90s
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
Authors:Chang, C, Gao, Y.
Deposit date:2022-03-07
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
Nat Commun, 13, 2022

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