8DYX
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7YQ3
| human insulin receptor bound with A43 DNA aptamer and insulin | Descriptor: | IR-A43 aptamer, Insulin A chain, Insulin, ... | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-08-05 | Release date: | 2022-11-09 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
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7YQ4
| human insulin receptor bound with A62 DNA aptamer and insulin - locally refined | Descriptor: | IR-A62 aptamer, Insulin A chain, Insulin, ... | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-08-05 | Release date: | 2022-11-09 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.95 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
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7YQ6
| human insulin receptor bound with A62 DNA aptamer | Descriptor: | IR-A62 aptamer, Isoform Short of Insulin receptor | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-08-05 | Release date: | 2022-11-09 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.18 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
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7YQ5
| human insulin receptor bound with A62 DNA aptamer and insulin | Descriptor: | IR-A62 aptamer, Insulin A chain, Insulin, ... | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-08-05 | Release date: | 2022-11-09 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.27 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures. Nat Commun, 13, 2022
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7YPZ
| Zafirlukast in complex with CRM1-Ran-RanBP1 | Descriptor: | 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... | Authors: | Sun, Q, Lei, Y. | Deposit date: | 2022-08-05 | Release date: | 2023-08-16 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Searching for Novel Noncovalent Nuclear Export Inhibitors through a Drug Repurposing Approach. J.Med.Chem., 66, 2023
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8DYZ
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7YPP
| Structural basis of a superoxide dismutase from a tardigrade, Ramazzottius varieornatus strain YOKOZUNA-1. | Descriptor: | CALCIUM ION, COPPER (II) ION, Superoxide dismutase [Cu-Zn], ... | Authors: | Sim, K.-S, Fukuda, Y, Inoue, T. | Deposit date: | 2022-08-04 | Release date: | 2023-07-26 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of a superoxide dismutase from a tardigrade: Ramazzottius varieornatus strain YOKOZUNA-1. Acta Crystallogr.,Sect.F, 79, 2023
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7YPR
| Structural basis of a superoxide dismutase from a tardigrade, Ramazzottius varieornatus strain YOKOZUNA-1. | Descriptor: | COPPER (II) ION, POTASSIUM ION, Superoxide dismutase [Cu-Zn], ... | Authors: | Sim, K.-S, Fukuda, Y, Inoue, T. | Deposit date: | 2022-08-04 | Release date: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | Structure of a superoxide dismutase from a tardigrade: Ramazzottius varieornatus strain YOKOZUNA-1. Acta Crystallogr.,Sect.F, 79, 2023
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8AMZ
| Spinach 19S proteasome | Descriptor: | 26S proteasome non-ATPase regulatory subunit 1 homolog, 26S proteasome non-ATPase regulatory subunit 2 homolog, 26S proteasome regulatory subunit 7, ... | Authors: | Kandolf, S, Grishkovskaya, I, Meinhart, A, Haselbach, D. | Deposit date: | 2022-08-04 | Release date: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structure of the plant 26S proteasome Plant Communications, 3, 2022
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8DYO
| Cryo-EM structure of Importin-4 bound to RanGTP | Descriptor: | GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-4, ... | Authors: | Bernardes, N.E, Fung, H.Y.J, Li, Y, Chen, Z, Chook, Y.M. | Deposit date: | 2022-08-04 | Release date: | 2022-09-21 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (7.1 Å) | Cite: | Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex. Proc.Natl.Acad.Sci.USA, 119, 2022
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8DYC
| Human CYP3A4 bound to a substrate | Descriptor: | 2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione, Cytochrome P450 3A4, GLYCEROL, ... | Authors: | Sevrioukova, I.F. | Deposit date: | 2022-08-04 | Release date: | 2022-10-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of CYP3A4 Complexed with Fluorol Identifies the Substrate Access Channel as a High-Affinity Ligand Binding Site. Int J Mol Sci, 23, 2022
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8AMR
| Coiled-coil domain of human TRIM3 | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, GLYCEROL, Tripartite motif-containing protein 3 | Authors: | Perez-Borrajero, C, Murciano, B, Hennig, J. | Deposit date: | 2022-08-04 | Release date: | 2023-11-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural and biophysical studies of TRIM2 and TRIM3 To Be Published
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8DYB
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7YPJ
| Spiral pentamer of the substrate-free Lon protease with a S678A mutation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-03 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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7YPK
| Close-ring hexamer of the substrate-bound Lon protease with an S678A mutation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease, alpha-S1-casein | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-03 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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7YPI
| Spiral hexamer of the substrate-free Lon protease with a Y224S mutation | Descriptor: | Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-03 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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7YPH
| Open-spiral pentamer of the substrate-free Lon protease with a Y224S mutation | Descriptor: | Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-03 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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8AMO
| Crystal structure of M. tuberculosis CYP143 | Descriptor: | CHLORIDE ION, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Bukhdruker, S, Varaksa, T, Grudo, A, Marin, E, Kapranov, I, Shevtsov, M, Gilep, A, Strushkevich, N, Borshchevskiy, V. | Deposit date: | 2022-08-03 | Release date: | 2023-02-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural insights into 3Fe-4S ferredoxins diversity in M. tuberculosis highlighted by a first redox complex with P450. Front Mol Biosci, 9, 2022
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8AMQ
| Crystal structure of the complex CYP143-FdxE from M. tuberculosis | Descriptor: | FE3-S4 CLUSTER, NICKEL (II) ION, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Bukhdruker, S, Varaksa, T, Smolskaya, S, Marin, E, Kapranov, I, Kovalev, K, Gilep, A, Strushkevich, N, Borshchevskiy, V. | Deposit date: | 2022-08-03 | Release date: | 2023-02-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural insights into 3Fe-4S ferredoxins diversity in M. tuberculosis highlighted by a first redox complex with P450. Front Mol Biosci, 9, 2022
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8AMC
| Crystal Structure of cat allergen Fel d 4 | Descriptor: | Allergen Fel d 4, SULFATE ION | Authors: | Schooltink, L, Sagmeister, T, Gottstein, N, Pavkov-Keller, T, Keller, W. | Deposit date: | 2022-08-03 | Release date: | 2023-08-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Crystal Structure of cat allergen Fel d 4 To Be Published
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8DXB
| HIV-1 reverse transcriptase/rilpivirine with bound fragment 5-fluoroindole-2-carboxylic acid at the NNRTI Adjacent site | Descriptor: | 1,2-ETHANEDIOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, 5-fluoroindole-2-carboxylic acid, ... | Authors: | Chopra, A, Ruiz, F.X, Bauman, J.D, Arnold, E. | Deposit date: | 2022-08-02 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. J.Med.Chem., 66, 2023
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8DXH
| HIV-1 reverse transcriptase/rilpivirine with bound fragment 5-fluoroquinazolin-4-ol at W266 site | Descriptor: | 1,2-ETHANEDIOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, 5-fluoranyl-3,4-dihydroquinazolin-4-ol, ... | Authors: | Chopra, A, Ruiz, F.X, Bauman, J.D, Arnold, E. | Deposit date: | 2022-08-02 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. J.Med.Chem., 66, 2023
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8DX8
| HIV-1 reverse transcriptase/rilpivirine with bound fragment 2-chloro-6-fluorophenethylamine at the 415 site | Descriptor: | 1,2-ETHANEDIOL, 2-(2-chloro-6-fluorophenyl)ethan-1-amine, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... | Authors: | Chopra, A, Ruiz, F.X, Bauman, J.D, Arnold, E. | Deposit date: | 2022-08-02 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. J.Med.Chem., 66, 2023
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8DXM
| HIV-1 reverse transcriptase/rilpivirine with bound fragment 4-bromophenol at the Knuckles site | Descriptor: | 1,2-ETHANEDIOL, 4-BROMOPHENOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... | Authors: | Chopra, A, Ruiz, F.X, Bauman, J.D, Arnold, E. | Deposit date: | 2022-08-02 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. J.Med.Chem., 66, 2023
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