PDB: 5495 resultsInfo pagesStatus searchChemie searchBIRD

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2BTP	14-3-3 Protein Theta (Human) Complexed to Peptide Descriptor: 14-3-3 PROTEIN TAU, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS Authors: Elkins, J.M, Johansson, A.C.E, Smee, C, Yang, X, Sundstrom, M, Edwards, A, Arrowsmith, C, Doyle, D.A, Structural Genomics Consortium (SGC) Deposit date: 2005-06-05 Release date: 2005-06-28 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
7UAS	Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization Descriptor: (5P)-2-[(S)-cyclopropyl(4-methylpyridin-2-yl)methyl]-5-[1-ethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-[(2-methyl-1H-imidazol-1-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one, WD repeat-containing protein 5 Authors: Zhao, B. Deposit date: 2022-03-14 Release date: 2022-05-04 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.808 Å) Cite: Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization. J.Med.Chem., 65, 2022
7U9Y	WDR5 bound to 2-(3,5-dimethoxybenzyl)-7-((2-methyl-1H-imidazol-1-yl)methyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-1(2H)-one Descriptor: (5P)-2-[(3,5-dimethoxyphenyl)methyl]-7-[(2-methyl-1H-imidazol-1-yl)methyl]-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,4-dihydroisoquinolin-1(2H)-one, BENZAMIDINE, WD repeat-containing protein 5 Authors: Rietz, T. Deposit date: 2022-03-11 Release date: 2022-04-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization. J.Med.Chem., 65, 2022
2COK	Solution structure of BRCT domain of poly(ADP-ribose) polymerase-1 Descriptor: Poly [ADP-ribose] polymerase-1 Authors: Nagashima, T, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-05-17 Release date: 2005-11-17 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of BRCT domain of poly(ADP-ribose) polymerase-1 To be Published
7V0E	Crystal structure of the macro-oligomeric form of DNMT3B methyltransferase domain. Descriptor: DNA (cytosine-5)-methyltransferase 3B, S-ADENOSYL-L-HOMOCYSTEINE Authors: Gao, L, Lu, J, Song, J. Deposit date: 2022-05-10 Release date: 2022-06-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.27016377 Å) Cite: Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations. Nat Commun, 13, 2022
7UTY	First bromodomain of BRD4 liganded with compound 2c Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, prop-2-en-1-yl (5S)-1-ethyl-7-methyl-5-(4-methylphenyl)-2,4-dioxo-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-6-carboxylate Authors: Schonbrunn, E, Chan, A. Deposit date: 2022-04-28 Release date: 2022-08-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.55 Å) Cite: 1,4-Dihydropyridinebutyrolactone-derived ring-opened ester and amide analogs targeting BET bromodomains. Arch Pharm, 355, 2022
2D8Z	Solution structure of the third LIM domain of Four and a half LIM domains protein 2 (FHL-2) Descriptor: Four and a half LIM domains 2, ZINC ION Authors: Qin, X.R, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-12-08 Release date: 2006-06-08 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the third LIM domain of Four and a half LIM domains protein 2 (FHL-2) To be published
7UJN	Structure of Human SAMHD1 with Non-Hydrolysable dGTP Analog Descriptor: 2'-deoxyguanosine-5'-O-(1-thiotriphosphate), Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Authors: Huynh, K.W, Ammirati, M, Han, S. Deposit date: 2022-03-31 Release date: 2022-07-20 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (2.89 Å) Cite: Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics. Nucleic Acids Res., 50, 2022
2CSH	Solution structure of tandem repeat of the zf-C2H2 domains of human zinc finger protein 297B Descriptor: ZINC ION, Zinc finger protein 297B Authors: Inoue, K, Saitoh, K, Hayashi, F, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-05-21 Release date: 2005-11-21 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of tandem repeat of the zf-C2H2 domains of human zinc finger protein 297B To be Published
2CKA	Solution structures of the BRK domains of the human Chromo Helicase Domain 7 and 8, reveals structural similarity with GYF domain suggesting a role in protein interaction Descriptor: CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 8 Authors: Ab, E, de Jong, R.N, Diercks, T, Xiaoyun, J, Daniels, M, Kaptein, R, Folkers, G.E. Deposit date: 2006-04-14 Release date: 2007-05-08 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Solution Structures of the Brk Domains of the Human Chromo Helicase Domain 7 and 8, Reveals Structural Similarity with Gyf Domain Suggesting a Role in Protein Interaction To be Published
2CO0	WDR5 and unmodified Histone H3 complex at 2.25 Angstrom Descriptor: HISTONE H3 DIMETHYL-LYSINE 4, WD-REPEAT PROTEIN 5 Authors: Ruthenburg, A.J, Wang, W, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L. Deposit date: 2006-05-25 Release date: 2006-07-03 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Histone H3 Recognition and Presentation by the Wdr5 Module of the Mll1 Complex Nat.Struct.Mol.Biol., 13, 2006
2F1O	Crystal Structure of NQO1 with Dicoumarol Descriptor: BISHYDROXY[2H-1-BENZOPYRAN-2-ONE,1,2-BENZOPYRONE], FLAVIN-ADENINE DINUCLEOTIDE, NAD(P)H dehydrogenase [quinone] 1 Authors: Shaul, Y, Asher, G, Dym, O, Tsvetkov, P, Adler, J, Israel Structural Proteomics Center (ISPC) Deposit date: 2005-11-15 Release date: 2006-05-16 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.75 Å) Cite: The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol. Biochemistry, 45, 2006
2FBX	WRN exonuclease, Mg complex Descriptor: MAGNESIUM ION, Werner syndrome helicase Authors: Perry, J.J. Deposit date: 2005-12-10 Release date: 2006-04-25 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.2 Å) Cite: WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat.Struct.Mol.Biol., 13, 2006
2FC0	WRN exonuclease, Mn dGMP complex Descriptor: 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, Werner syndrome helicase Authors: Perry, J.J, Tainer, J.A. Deposit date: 2005-12-10 Release date: 2006-04-25 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat.Struct.Mol.Biol., 13, 2006
2FBY	WRN exonuclease, Eu complex Descriptor: EUROPIUM (III) ION, Werner syndrome helicase Authors: Perry, J.J. Deposit date: 2005-12-10 Release date: 2006-04-25 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat.Struct.Mol.Biol., 13, 2006
2FC9	Solution structure of the RRM_1 domain of NCL protein Descriptor: NCL protein Authors: Dang, W, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-12-12 Release date: 2006-06-12 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the RRM_1 domain of NCL protein To be published
2F8N	2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes Descriptor: Core histone macro-H2A.1, Histone 3, H2ba, ... Authors: Chakravarthy, S, Luger, K. Deposit date: 2005-12-02 Release date: 2006-05-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Nucleosomes containing the histone domain of macroH2A: In vitro possibilities. To be Published
2FHO	NMR solution structure of the human spliceosomal protein complex p14-SF3b155 Descriptor: spliceosomal protein SF3b155, spliceosomal protein p14 Authors: Kuwasako, K, Dohmae, N, Inoue, M, Shirouzu, M, Guntert, P, Seraphin, B, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-12-26 Release date: 2006-12-26 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: NMR solution structure of the human spliceosomal protein complex p14-SF3b155 To be Published
2CPJ	Solution structure of the N-terminal RNA recognition motif of NonO Descriptor: Non-POU domain-containing octamer-binding protein Authors: Nagata, T, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-05-19 Release date: 2005-11-19 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the N-terminal RNA recognition motif of NonO To be Published
2CPR	Solution structure of the HRDC domain of human Exosome component 10 Descriptor: Exosome component 10 Authors: Nagata, T, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-05-19 Release date: 2005-11-19 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the HRDC domain of human Exosome component 10 To be Published
2FBT	WRN exonuclease Descriptor: ACETIC ACID, Werner syndrome helicase Authors: Perry, J.J. Deposit date: 2005-12-10 Release date: 2006-04-25 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.05 Å) Cite: WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat.Struct.Mol.Biol., 13, 2006
2FBV	WRN exonuclease, Mn complex Descriptor: MANGANESE (II) ION, Werner syndrome helicase Authors: Perry, J.J. Deposit date: 2005-12-10 Release date: 2006-04-25 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.4 Å) Cite: WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat.Struct.Mol.Biol., 13, 2006
2DNY	Solution structure of the third RNA binding domain of FBP-interacting repressor, SIAHBP1 Descriptor: Fuse-binding protein-interacting repressor, isoform b Authors: Suzuki, S, Nagata, T, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-04-27 Release date: 2007-04-17 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the third RNA binding domain of FBP-interacting repressor, SIAHBP1 To be Published
2G76	Crystal structure of human 3-phosphoglycerate dehydrogenase Descriptor: D-3-phosphoglycerate dehydrogenase, D-MALATE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Turnbull, A.P, Salah, E, Savitsky, P, Gileadi, O, von Delft, F, Edwards, A, Arrowsmith, C, Weigelt, J, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC) Deposit date: 2006-02-27 Release date: 2006-03-21 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of human 3-phosphoglycerate dehydrogenase To be Published
2D9P	Solution structure of RNA binding domain 4 in Polyadenylation binding protein 3 Descriptor: Polyadenylate-binding protein 3 Authors: Tsuda, K, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-12-12 Release date: 2006-06-12 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of RNA binding domain 4 in Polyadenylation binding protein 3 To be Published

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