7UTY

First bromodomain of BRD4 liganded with compound 2c

Summary for 7UTY

• Entry DOI: 10.2210/pdb7uty/pdb
• Descriptor: Bromodomain-containing protein 4, prop-2-en-1-yl (5S)-1-ethyl-7-methyl-5-(4-methylphenyl)-2,4-dioxo-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-6-carboxylate, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: inhibitor, acetyl-lysine, transcription regulation, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 15604.94

Authors

Schonbrunn, E.,Chan, A. (deposition date: 2022-04-28, release date: 2022-08-24, Last modification date: 2023-10-18)

• Primary citation: Jiang, J.,Zhao, P.L.,Sigua, L.H.,Chan, A.,Schonbrunn, E.,Qi, J.,Georg, G.I.; 1,4-Dihydropyridinebutyrolactone-derived ring-opened ester and amide analogs targeting BET bromodomains.; Arch Pharm, 355:e2200288-e2200288, 2022; PubMed: 35941525; DOI: 10.1002/ardp.202200288

Experimental method

X-RAY DIFFRACTION (1.55 Å)