PDB: 46188 resultsInfo pagesStatus searchChemie searchBIRD

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1T6R	Solution structure of TM1442, a putative anti sigma factor antagonist in phosphorylated state Descriptor: Putative anti-sigma factor antagonist TM1442 Authors: Etezady-Esfarjani, T, Placzek, W, Herrmann, T, Lesley, S.A, Wuthrich, K, Joint Center for Structural Genomics (JCSG) Deposit date: 2004-05-07 Release date: 2005-05-24 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: Solution structures of the putative anti-sigma-factor antagonist TM1442 from Thermotoga maritima in the free and phosphorylated states. Magn.Reson.Chem., 44 Spec No, 2006
6GHO	Crystal structure of Spx in complex with YjbH Descriptor: CHLORIDE ION, Regulatory protein Spx, UPF0413 protein GK0824 Authors: Awad, W, Logan, D.T, von Wachenfeldt, C. Deposit date: 2018-05-08 Release date: 2019-04-24 Last modified: 2019-06-19 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Structural Basis for YjbH Adaptor-Mediated Recognition of Transcription Factor Spx. Structure, 27, 2019
7E73	Crystal structure of human ERK2 mutant (Y36H) Descriptor: Mitogen-activated protein kinase 1, SULFATE ION Authors: Park, Y.S, Kim, M, Ryu, S.E. Deposit date: 2021-02-25 Release date: 2022-03-02 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Structural mechanism of inhibitor-resistance by ERK2 mutations Biodesign, 9, 2021
7E75	Crystal structure of human ERK2 mutant (G37C) Descriptor: Mitogen-activated protein kinase 1 Authors: Park, Y.S, Kim, M, Ryu, S.E. Deposit date: 2021-02-25 Release date: 2022-03-02 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.481 Å) Cite: Structural mechanism of inhibitor-resistance by ERK2 mutations Biodesign, 9, 2021
3NAM	SR Ca(2+)-ATPase in the HnE2 state complexed with the Thapsigargin derivative dOTg Descriptor: (3S,3aR,4S,6S,6aS,8R,9R,9aR,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-2-oxododecahydroazuleno[4,5-b]furan-8-yl (2Z)-2-methylbut-2-enoate, MAGNESIUM ION, PHOSPHATIDYLETHANOLAMINE, ... Authors: Winther, A.M.L, Sonntag, Y, Olesen, C, Moller, J.V, Nissen, P. Deposit date: 2010-06-02 Release date: 2010-06-30 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Critical roles of hydrophobicity and orientation of side chains for inactivation of sarcoplasmic reticulum Ca2+-ATPase with thapsigargin and thapsigargin analogs J.Biol.Chem., 285, 2010
3TW1	Structure of Rtt106-AHN Descriptor: GLYCEROL, Histone chaperone RTT106, N-[2-(1H-IMIDAZOL-4-YL)ETHYL]ACETAMIDE Authors: Su, D, Thompson, J.R, Mer, G. Deposit date: 2011-09-21 Release date: 2012-02-01 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.772 Å) Cite: Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106. Nature, 483, 2012
1YXT	Crystal Structure of Kinase Pim1 in complex with AMPPNP Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Proto-oncogene serine/threonine-protein kinase Pim-1 Authors: Kumar, A, Mandiyan, V, Suzuki, Y, Zhang, C, Rice, J, Tsai, J, Artis, D.R, Ibrahim, P, Bremer, R. Deposit date: 2005-02-22 Release date: 2005-04-26 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma. J.Mol.Biol., 348, 2005
1ZKA	NF-kB RelB forms an intertwined homodimer, Y300S mutant Descriptor: Transcription factor RelB Authors: Huang, D.B, Vu, D, Ghosh, G. Deposit date: 2005-05-02 Release date: 2005-05-10 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.2 Å) Cite: NF-kappaB RelB forms an intertwined homodimer. Structure, 13, 2005
3NKX	Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome Descriptor: 14-3-3 protein zeta/delta, PROPANOIC ACID, Peptide of RAF proto-oncogene serine/threonine-protein kinase Authors: Schumacher, B, Weyand, M, Ottmann, C. Deposit date: 2010-06-21 Release date: 2010-09-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling Mol.Cell.Biol., 30, 2010
1UTD	The structure of the trp RNA-binding attenuation protein (TRAP) bound to a 63-nucleotide RNA molecule containing GAGUUU repeats Descriptor: 5'-R(*GP*UP*UP*UP*GP*AP)-3', TRANSCRIPTION ATTENUATION PROTEIN MTRB, TRYPTOPHAN Authors: Hopcroft, N.H, Manfredo, A, Wendt, A.L, Brzozowski, A.M, Gollnick, P, Antson, A.A. Deposit date: 2003-12-08 Release date: 2004-01-15 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The Interaction of RNA with Trap: The Role of Triplet Repeats and Separating Spacer Nucleotides J.Mol.Biol., 338, 2004
1VC1	Crystal structure of the TM1442 protein from Thermotoga maritima, a homolog of the Bacillus subtilis general stress response anti-anti-sigma factor RsbV Descriptor: Putative anti-sigma factor antagonist TM1442 Authors: Lee, J.Y, Ahn, H.J, Ha, K.S, Suh, S.W. Deposit date: 2004-03-03 Release date: 2004-09-28 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of the TM1442 protein from Thermotoga maritima, a homolog of the Bacillus subtilis general stress response anti-anti-sigma factor RsbV Proteins, 56, 2004
1R7R	The crystal structure of murine p97/VCP at 3.6A Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase Authors: Huyton, T, Pye, V.E, Briggs, L.C, Flynn, T.C, Beuron, F, Kondo, H, Ma, J, Zhang, X, Freemont, P.S. Deposit date: 2003-10-22 Release date: 2003-12-16 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (3.6 Å) Cite: The crystal structure of murine p97/VCP at 3.6A J.Struct.Biol., 144, 2003
2LT1	Solution NMR structure of the 72-residue N-terminal domain of Myxococcus xanthus CarD Descriptor: CarD protein Authors: Jimenez, M.A, Padmanabhan, S. Deposit date: 2012-05-10 Release date: 2013-11-13 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structure-Function Dissection of Myxococcus xanthus CarD N-Terminal Domain, a Defining Member of the CarD_CdnL_TRCF Family of RNA Polymerase Interacting Proteins. Plos One, 10
3PSK	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Native Spt6 (1247-1451) Descriptor: SULFATE ION, Transcription elongation factor SPT6 Authors: Close, D, Hill, C.P. Deposit date: 2010-12-01 Release date: 2011-03-30 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
3PUP	Structure of Glycogen Synthase Kinase 3 beta (GSK3B) in complex with a ruthenium octasporine ligand (OS1) Descriptor: Glycogen synthase kinase-3 beta, Ruthenium octasporine Authors: Filippakopoulos, P, Kraling, K, Essen, L.O, Meggers, E, Knapp, S. Deposit date: 2010-12-06 Release date: 2010-12-22 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.99 Å) Cite: Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors. J.Am.Chem.Soc., 133, 2011
2JM1	Structures and chemical shift assignments for the ADD domain of the ATRX protein Descriptor: Transcriptional regulator ATRX, ZINC ION Authors: Yang, J, Neuhaus, D. Deposit date: 2006-09-13 Release date: 2007-06-26 Last modified: 2024-05-08 Method: SOLUTION NMR Cite: Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX. Proc.Natl.Acad.Sci.USA, 104, 2007
2AHP	GCN4 leucine zipper, mutation of Lys15 to epsilon-azido-Lys Descriptor: General control protein GCN4 Authors: Horne, W.S, Ghadiri, M.R. Deposit date: 2005-07-28 Release date: 2006-08-01 Last modified: 2024-07-10 Method: X-RAY DIFFRACTION (2 Å) Cite: GCN4 leucine zipper, mutation of Lys15 to epsilon-azido-Lys To be Published
3Q3B	6-Amino-4-(pyrimidin-4-yl)pyridones: Novel Glycogen Synthase Kinase-3 Inhibitors Descriptor: 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one, Glycogen synthase kinase-3 beta Authors: Pandit, J. Deposit date: 2010-12-21 Release date: 2011-06-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.7 Å) Cite: 6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3β inhibitors Bioorg.Med.Chem.Lett., 21, 2011
3HD0	Crystal structure of Tm1865, an Endonuclease V from Thermotoga Maritima Descriptor: Endonuclease V Authors: Utepbergenov, D, Cooper, D.R, Derewenda, U, Derewenda, Z.S, Integrated Center for Structure and Function Innovation (ISFI) Deposit date: 2009-05-06 Release date: 2009-07-14 Last modified: 2017-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of Tm1865, an Endonuclease V from Thermotoga Maritima To be Published
1AUZ	SOLUTION STRUCTURE OF SPOIIAA, A PHOSPHORYLATABLE COMPONENT OF THE SYSTEM THAT REGULATES TRANSCRIPTION FACTOR SIGMA-F OF BACILLUS SUBTILIS, NMR, 24 STRUCTURES Descriptor: SPOIIAA Authors: Kovacs, H, Comfort, D, Lord, M, Campbell, I.D, Yudkin, M.D. Deposit date: 1997-09-08 Release date: 1998-07-01 Last modified: 2024-04-10 Method: SOLUTION NMR Cite: Solution structure of SpoIIAA, a phosphorylatable component of the system that regulates transcription factor sigmaF of Bacillus subtilis. Proc.Natl.Acad.Sci.USA, 95, 1998
3H20	Crystal structure of primase RepB' Descriptor: DIPHOSPHATE, Replication protein B, SULFATE ION Authors: Geibel, S, Banchenko, S, Engel, M, Lanka, E, Saenger, W. Deposit date: 2009-04-14 Release date: 2009-04-28 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Structure and function of primase RepB' encoded by broad-host-range plasmid RSF1010 that replicates exclusively in leading-strand mode Proc.Natl.Acad.Sci.USA, 106, 2009
3PQB	The crystal structure of pregilvocarcin in complex with GilR, an oxidoreductase that catalyzes the terminal step of gilvocarcin biosynthesis Descriptor: (1R)-1,4-anhydro-6-deoxy-1-[(6R)-8-ethenyl-1,6-dihydroxy-10,12-dimethoxy-6H-dibenzo[c,h]chromen-4-yl]-D-galactitol, FLAVIN-ADENINE DINUCLEOTIDE, Putative oxidoreductase Authors: Noinaj, N, Bosserman, M.A, Schickli, M.A, Kharel, M.K, Rohr, J, Buchanan, S.K. Deposit date: 2010-11-25 Release date: 2011-05-11 Last modified: 2011-08-03 Method: X-RAY DIFFRACTION (2.324 Å) Cite: The Crystal Structure and Mechanism of an Unusual Oxidoreductase, GilR, Involved in Gilvocarcin V Biosynthesis. J.Biol.Chem., 286, 2011
4II2	Crystal structure of Ubiquitin activating enzyme 1 (Uba1) in complex with the Ub E2 Ubc4, ubiquitin, and ATP/Mg Descriptor: 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Olsen, S.K, Lima, C.D. Deposit date: 2012-12-19 Release date: 2013-02-13 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer. Mol.Cell, 49, 2013
2B22	Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat Descriptor: General control protein GCN4, SODIUM ION Authors: Deng, Y, Liu, J, Zheng, Q, Eliezer, D, Kallenbach, N.R, Lu, M. Deposit date: 2005-09-16 Release date: 2006-01-31 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2 Å) Cite: Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat. Structure, 14, 2006
1Q5Y	Nickel-Bound C-terminal Regulatory Domain of NikR Descriptor: 1,2-ETHANEDIOL, NICKEL (II) ION, Nickel responsive regulator Authors: Schreiter, E.R, Sintchak, M.D, Guo, Y, Chivers, P.T, Sauer, R.T, Drennan, C.L. Deposit date: 2003-08-11 Release date: 2003-09-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Crystal Structure of the Nickel-Responsive Transcription Factor NikR Nat.Struct.Biol., 10, 2003

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