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7XEO	MbetaCD treated state of mTRPV2 Descriptor: Transient receptor potential cation channel subfamily V member 2 Authors: Su, N. Deposit date: 2022-03-31 Release date: 2022-08-17 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (2.89 Å) Cite: Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
7XEU	Structure of mTRPV2_E2 Descriptor: CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2 Authors: Su, N. Deposit date: 2022-03-31 Release date: 2022-08-17 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (2.77 Å) Cite: Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
7XEW	Structure of mTRPV2_Q525F Descriptor: Transient receptor potential cation channel subfamily V member 2 Authors: Su, N. Deposit date: 2022-03-31 Release date: 2022-08-17 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (2.59 Å) Cite: Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
7XER	Structure of mTRPV2_Q525T Descriptor: CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2 Authors: Su, N. Deposit date: 2022-03-31 Release date: 2022-08-17 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (2.47 Å) Cite: Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
7YEP	2-APB bound state of mTRPV2 Descriptor: 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2 Authors: Su, N. Deposit date: 2022-07-06 Release date: 2022-08-17 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (2.83 Å) Cite: Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
8SLY	Rat TRPV2 bound with 2 CBD ligands in nanodiscs Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 2, ... Authors: Tan, X, Swartz, K.J. Deposit date: 2023-04-24 Release date: 2023-05-31 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.32 Å) Cite: Cannabidiol sensitizes TRPV2 channels to activation by 2-APB. Elife, 12, 2023
8SLX	Rat TRPV2 bound with 1 CBD ligand in nanodiscs Descriptor: SODIUM ION, Transient receptor potential cation channel subfamily V member 2, cannabidiol Authors: Tan, X, Swartz, K.J. Deposit date: 2023-04-24 Release date: 2023-05-31 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.23 Å) Cite: Cannabidiol sensitizes TRPV2 channels to activation by 2-APB. Elife, 12, 2023
7X6C	Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class1 Descriptor: (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, ... Authors: Won, J, Jeong, H, Lee, H.H. Deposit date: 2022-03-07 Release date: 2023-05-24 Method: ELECTRON MICROSCOPY (3.15 Å) Cite: Molecular architecture of the G alpha i -bound TRPC5 ion channel. Nat Commun, 14, 2023
7UGG	Cryo-EM structure of TRPV3 in complex with the anesthetic dyclonine Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Dyclonine, SODIUM ION, ... Authors: Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. Deposit date: 2022-03-24 Release date: 2022-06-08 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (3.16 Å) Cite: Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine. Nat Commun, 13, 2022
6DVY	Cryo-EM structure of mouse TRPV3 in complex with 2-Aminoethoxydiphenyl borate (2-APB) Descriptor: 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 3 Authors: Singh, A.K, McGoldrick, L.L, Sobolevsky, A.I. Deposit date: 2018-06-25 Release date: 2018-09-05 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (4 Å) Cite: Structure and gating mechanism of the transient receptor potential channel TRPV3. Nat. Struct. Mol. Biol., 25, 2018
6DVW	Cryo-EM structure of mouse TRPV3 Descriptor: Transient receptor potential cation channel subfamily V member 3 Authors: Singh, A.K, McGoldrick, L.L, Sobolevsky, A.I. Deposit date: 2018-06-25 Release date: 2018-09-05 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Structure and gating mechanism of the transient receptor potential channel TRPV3. Nat. Struct. Mol. Biol., 25, 2018
7D2K	Crystal structure of rat TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor Br-cis-22a Descriptor: 1-(5-bromanylpyridin-3-yl)-4-[4-(3-methylphenyl)cyclohexyl]piperazin-4-ium, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 Authors: Singh, A.K, Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. Deposit date: 2020-09-16 Release date: 2021-10-06 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.698 Å) Cite: Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020
3HNB	Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor Descriptor: (2R)-1-(2,4-dichlorophenoxy)-3-[(2E)-2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]propan-2-ol, Coagulation factor VIII Authors: Liu, Z, Yuan, C. Deposit date: 2009-05-31 Release date: 2010-01-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. J.Biol.Chem., 285, 2010
3HNY	Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor Descriptor: Coagulation factor VIII Authors: Liu, Z, Yuan, C. Deposit date: 2009-06-01 Release date: 2010-01-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.07 Å) Cite: Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. J.Biol.Chem., 285, 2010
8TF3	Wildtype rabbit TRPV5 into nanodiscs in complex with econazole Descriptor: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE, ERGOSTEROL, ... Authors: De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y. Deposit date: 2023-07-07 Release date: 2024-01-10 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Structural mechanism of TRPV5 inhibition by econazole. Structure, 32, 2024
8TF2	Wildtype rabbit TRPV5 into nanodiscs in Apo state Descriptor: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ERGOSTEROL, Transient receptor potential cation channel subfamily V member 5 Authors: De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y. Deposit date: 2023-07-07 Release date: 2024-01-10 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (2.57 Å) Cite: Structural mechanism of TRPV5 inhibition by econazole. Structure, 32, 2024
8TF4	Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and econazole Descriptor: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE, ERGOSTEROL, ... Authors: De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y. Deposit date: 2023-07-07 Release date: 2024-01-10 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: Structural mechanism of TRPV5 inhibition by econazole. Structure, 32, 2024
3HOB	Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor Descriptor: Coagulation factor VIII Authors: Liu, Z, Yuan, C. Deposit date: 2009-06-01 Release date: 2010-01-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. J.Biol.Chem., 285, 2010
6AYF	TRPML3/ML-SA1 complex at pH 7.4 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-3 Authors: Zhou, X, Li, M, Su, D, Jia, Q, Li, H, Li, X, Yang, J. Deposit date: 2017-09-08 Release date: 2017-11-08 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.62 Å) Cite: Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states. Nat. Struct. Mol. Biol., 24, 2017
5WO9	Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6* in the presence of Calcium Descriptor: 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 Authors: Singh, A.K, Saotome, K, Sobolevsky, A.I. Deposit date: 2017-08-01 Release date: 2017-09-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.7 Å) Cite: Swapping of transmembrane domains in the epithelial calcium channel TRPV6. Sci Rep, 7, 2017
5WO8	Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6*-Del1 Descriptor: 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 Authors: Singh, A.K, Saotome, K, Sobolevsky, A.I. Deposit date: 2017-08-01 Release date: 2017-09-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Swapping of transmembrane domains in the epithelial calcium channel TRPV6. Sci Rep, 7, 2017
5WOA	Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6* in the presence of Gadolinium Descriptor: GADOLINIUM ATOM, Transient receptor potential cation channel subfamily V member 6 Authors: Singh, A.K, Saotome, K, Sobolevsky, A.I. Deposit date: 2017-08-01 Release date: 2017-10-04 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.899 Å) Cite: Swapping of transmembrane domains in the epithelial calcium channel TRPV6. Sci Rep, 7, 2017
5WO7	Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6* Descriptor: 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 Authors: Singh, A.K, Saotome, K, Sobolevsky, A.I. Deposit date: 2017-08-01 Release date: 2017-09-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.246 Å) Cite: Swapping of transmembrane domains in the epithelial calcium channel TRPV6. Sci Rep, 7, 2017
5WO6	Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6cryst Descriptor: 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 Authors: Singh, A.K, Saotome, K, Sobolevsky, A.I. Deposit date: 2017-08-01 Release date: 2017-09-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.31 Å) Cite: Swapping of transmembrane domains in the epithelial calcium channel TRPV6. Sci Rep, 7, 2017
8FFQ	Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and ruthenium red Descriptor: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ERGOSTEROL, Transient receptor potential cation channel subfamily V member 5, ... Authors: De Jesus-Perez, J.J, Fluck, E.C, Pumroy, R.A, Protopopova, A.D, Rocereta, J.A, Moiseenkova-Bell, V.Y. Deposit date: 2022-12-09 Release date: 2024-02-07 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (2.65 Å) Cite: Molecular details of ruthenium red pore block in TRPV channels. Embo Rep., 25, 2024

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