5WOA

Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6* in the presence of Gadolinium

Summary for 5WOA

Entry DOI	10.2210/pdb5woa/pdb
Descriptor	Transient receptor potential cation channel subfamily V member 6, GADOLINIUM ATOM (2 entities in total)
Functional Keywords	ion channel, transporter, membrane protein
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	1
Total formula weight	77447.99
Authors	Singh, A.K.,Saotome, K.,Sobolevsky, A.I. (deposition date: 2017-08-01, release date: 2017-10-04, Last modification date: 2023-10-04)
Primary citation	Singh, A.K.,Saotome, K.,Sobolevsky, A.I. Swapping of transmembrane domains in the epithelial calcium channel TRPV6. Sci Rep, 7:10669-10669, 2017 Cited by PubMed Abstract: Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states. PubMed: 28878326 DOI: 10.1038/s41598-017-10993-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.899 Å)

Structure validation