6JHN
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![BU of 6jhn by Molmil](/molmil-images/mine/6jhn) | Structure of RyR2 (F/C/Ca2+ dataset) | Descriptor: | CAFFEINE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | Authors: | Chi, X.M, Gong, D.S, Ren, K, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Zhou, Q, Yan, N. | Deposit date: | 2019-02-18 | Release date: | 2019-12-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators. Proc.Natl.Acad.Sci.USA, 116, 2019
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6JRR
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![BU of 6jrr by Molmil](/molmil-images/mine/6jrr) | Structure of RyR2 (*F/A/C/L-Ca2+ dataset) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | Authors: | Gong, D.S, Chi, X.M, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Yan, N. | Deposit date: | 2019-04-05 | Release date: | 2019-07-17 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Modulation of cardiac ryanodine receptor 2 by calmodulin. Nature, 572, 2019
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6JH6
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![BU of 6jh6 by Molmil](/molmil-images/mine/6jh6) | Structure of RyR2 (F/A/Ca2+ dataset) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, RyR2, ... | Authors: | Chi, X.M, Gong, D.S, Ren, K, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Zhou, Q, Yan, N. | Deposit date: | 2019-02-17 | Release date: | 2019-12-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators. Proc.Natl.Acad.Sci.USA, 116, 2019
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3BQ6
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6L6Z
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6KOF
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![BU of 6kof by Molmil](/molmil-images/mine/6kof) | Crystal structure of indoleamine 2,3-dioxygenagse 1 (IDO1) in complex with compound 47 | Descriptor: | 1-(4-cyanophenyl)-3-[[3-(2-cyclopropylethynyl)imidazo[2,1-b][1,3]thiazol-5-yl]methyl]thiourea, Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Peng, Y.H, Wu, S.Y. | Deposit date: | 2019-08-09 | Release date: | 2020-03-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.263 Å) | Cite: | Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors. J.Med.Chem., 63, 2020
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6KW7
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![BU of 6kw7 by Molmil](/molmil-images/mine/6kw7) | Crystal structure of indoleamine 2,3-dioxygenagse 1 (IDO1) in complex with compound 12 | Descriptor: | 3-(4-bromophenyl)imidazo[2,1-b][1,3]thiazole, Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Peng, Y.H, Wu, S.Y. | Deposit date: | 2019-09-06 | Release date: | 2020-03-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.02 Å) | Cite: | Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors. J.Med.Chem., 63, 2020
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3EK6
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3FE5
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![BU of 3fe5 by Molmil](/molmil-images/mine/3fe5) | Crystal structure of 3-hydroxyanthranilate 3,4-dioxygenase from bovine kidney | Descriptor: | 3-hydroxyanthranilate 3,4-dioxygenase, FE (III) ION | Authors: | Dilovic, I, Gliubich, F, Malpeli, G, Zanotti, G, Matkovic-Calogovic, D. | Deposit date: | 2008-11-27 | Release date: | 2009-06-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Crystal structure of bovine 3-hydroxyanthranilate 3,4-dioxygenase. Biopolymers, 2009
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3GRI
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![BU of 3gri by Molmil](/molmil-images/mine/3gri) | The Crystal Structure of a Dihydroorotase from Staphylococcus aureus | Descriptor: | CALCIUM ION, CHLORIDE ION, Dihydroorotase, ... | Authors: | Brunzelle, J.S, Wawrzak, Z, Skarina, T, Onopriyenko, O, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2009-03-25 | Release date: | 2009-05-19 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Crystal Structure of a Dihydroorotase from Staphylococcus aureus To be Published
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3H9R
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![BU of 3h9r by Molmil](/molmil-images/mine/3h9r) | Crystal structure of the kinase domain of type I activin receptor (ACVR1) in complex with FKBP12 and dorsomorphin | Descriptor: | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, Activin receptor type-1, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | Authors: | Chaikuad, A, Alfano, I, Shrestha, B, Muniz, J.R.C, Petrie, K, Fedorov, O, Phillips, C, Bishop, S, Mahajan, P, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Bullock, A, Structural Genomics Consortium (SGC) | Deposit date: | 2009-04-30 | Release date: | 2009-06-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva. J.Biol.Chem., 287, 2012
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3HID
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![BU of 3hid by Molmil](/molmil-images/mine/3hid) | Crystal structure of adenylosuccinate synthetase from Yersinia pestis CO92 | Descriptor: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, Adenylosuccinate synthetase | Authors: | Zhang, R, Zhou, M, Peterson, S, Anderson, W, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2009-05-19 | Release date: | 2009-06-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The crystal structure of the adenylosuccinate synthetase from Yersinia pestis CO92 To be Published
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4J8L
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![BU of 4j8l by Molmil](/molmil-images/mine/4j8l) | CRYSTAL STRUCTURE OF THE PYRIDOXAL-5'-PHOSPHATE DEPENDENT protein YhfS from Escherichia coli | Descriptor: | ACETIC ACID, DI(HYDROXYETHYL)ETHER, NICKEL (II) ION, ... | Authors: | Fedorov, A.A, Fedorov, E.V, Xiang, D.F, Raushel, F.M, Almo, S.C. | Deposit date: | 2013-02-14 | Release date: | 2014-03-05 | Method: | X-RAY DIFFRACTION (1.651 Å) | Cite: | Crystal structure of the pyridoxal-5'-phosphate dependent protein yhfs from escherichia coli To be Published
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4IPX
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![BU of 4ipx by Molmil](/molmil-images/mine/4ipx) | Analyzing the visible conformational substates of the FK506 binding protein FKBP12 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Peptidyl-prolyl cis-trans isomerase FKBP1A | Authors: | Chen, H, Mustafi, S.M, Li, H.M, LeMaster, D.M, Hernandez, G. | Deposit date: | 2013-01-10 | Release date: | 2013-06-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Analysing the visible conformational substates of the FK506-binding protein FKBP12. Biochem.J., 453, 2013
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4IQ2
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![BU of 4iq2 by Molmil](/molmil-images/mine/4iq2) | P21 crystal form of FKBP12.6 | Descriptor: | MALONIC ACID, Peptidyl-prolyl cis-trans isomerase FKBP1B | Authors: | Chen, H, Mustafi, S.M, Li, H.M, LeMaster, D.M, Hernandez, G. | Deposit date: | 2013-01-10 | Release date: | 2014-01-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure and conformational flexibility of the unligated FK506-binding protein FKBP12.6. Acta Crystallogr.,Sect.D, 70, 2014
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4IQC
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![BU of 4iqc by Molmil](/molmil-images/mine/4iqc) | P3121 crystal form of FKBP12.6 | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1B | Authors: | Chen, H, Mustafi, S.M, Li, H.M, LeMaster, D.M, Hernandez, G. | Deposit date: | 2013-01-11 | Release date: | 2014-01-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.903 Å) | Cite: | Crystal structure and conformational flexibility of the unligated FK506-binding protein FKBP12.6. Acta Crystallogr.,Sect.D, 70, 2014
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4L61
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4L64
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![BU of 4l64 by Molmil](/molmil-images/mine/4l64) | Crystal structure of the Candida albicans Methionine Synthase in complex with 5-Methyl-Tetrahydrofolate | Descriptor: | 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, ZINC ION | Authors: | Ubhi, D, Robertus, J.D. | Deposit date: | 2013-06-11 | Release date: | 2014-03-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Structural analysis of a fungal methionine synthase with substrates and inhibitors. J.Mol.Biol., 426, 2014
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3I65
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![BU of 3i65 by Molmil](/molmil-images/mine/3i65) | Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM1 | Descriptor: | 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, Dihydroorotate dehydrogenase homolog, mitochondrial, ... | Authors: | Deng, X, Phillips, M.A. | Deposit date: | 2009-07-06 | Release date: | 2009-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds. J.Biol.Chem., 284, 2009
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4L6O
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4LGY
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![BU of 4lgy by Molmil](/molmil-images/mine/4lgy) | Importance of Hydrophobic Cavities in Allosteric Regulation of Formylglycinamide Synthetase: Insight from Xenon Trapping and Statistical Coupling Analysis | Descriptor: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | Authors: | Tanwar, A.S, Goyal, V.D, Choudhary, D, Panjikar, S, Anand, R. | Deposit date: | 2013-06-30 | Release date: | 2013-12-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Importance of hydrophobic cavities in allosteric regulation of formylglycinamide synthetase: insight from xenon trapping and statistical coupling analysis Plos One, 8, 2013
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4L2N
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![BU of 4l2n by Molmil](/molmil-images/mine/4l2n) | Understanding Extradiol Dioxygenase Mechanism in NAD+ Biosynthesis by Viewing Catalytic Intermediates - ligand-free structure | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate 3,4-dioxygenase, CHLORIDE ION, ... | Authors: | Liu, F, Liu, A. | Deposit date: | 2013-06-04 | Release date: | 2015-05-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | An Iron Reservoir to the Catalytic Metal: THE RUBREDOXIN IRON IN AN EXTRADIOL DIOXYGENASE. J.Biol.Chem., 290, 2015
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4KGV
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![BU of 4kgv by Molmil](/molmil-images/mine/4kgv) | The R state structure of E. coli ATCase with ATP bound | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Aspartate carbamoyltransferase, Aspartate carbamoyltransferase regulatory chain, ... | Authors: | Cockrell, G.M, Zheng, Y, Guo, W, Peterson, A.W, Kantrowitz, E.R. | Deposit date: | 2013-04-29 | Release date: | 2013-11-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | New Paradigm for Allosteric Regulation of Escherichia coli Aspartate Transcarbamoylase. Biochemistry, 52, 2013
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3I68
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4L6H
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![BU of 4l6h by Molmil](/molmil-images/mine/4l6h) | |