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4L6H

Crystal structure of the Candida albicans Methionine Synthase in complex with Methotrexate and Homocysteine

Summary for 4L6H
Entry DOI10.2210/pdb4l6h/pdb
Related4L5Z 4L61 4L64 4L65 4L6O
Descriptor5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, ZINC ION, 2-AMINO-4-MERCAPTO-BUTYRIC ACID, ... (5 entities in total)
Functional Keywordscobalamin-independent, surface entropy reduction, fungal, dual tim barrels, methionine synthase, transferase
Biological sourceCandida albicans SC5314
Total number of polymer chains1
Total formula weight88843.99
Authors
Ubhi, D.,Robertus, J.D. (deposition date: 2013-06-12, release date: 2014-03-05, Last modification date: 2024-02-28)
Primary citationUbhi, D.,Kago, G.,Monzingo, A.F.,Robertus, J.D.
Structural analysis of a fungal methionine synthase with substrates and inhibitors.
J.Mol.Biol., 426:1839-1847, 2014
Cited by
PubMed: 24524835
DOI: 10.1016/j.jmb.2014.02.006
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

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